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Ageratum conyzoides L. and Its Secondary Metabolites in the Management of Different Fungal Pathogens
Rubal Chahal Arun Nanda Esra Küpeli Akkol Eduardo Sobarzo-Snchez Ashwani Arya Deepak Kaushik Rohit Dutt Rashmi Bhardwaj Md. Habibur Rahman Vineet Mittal 《Molecules (Basel, Switzerland)》2021,26(10)
Ageratum conyzoides L. (Family—Asteraceae) is an annual aromatic invasive herb, mainly distributed over the tropical and subtropical regions of the world. It owns a reputed history of indigenous remedial uses, including as a wound dressing, an antimicrobial, and mouthwash as well as in treatment of dysentery, diarrhea, skin diseases, etc. In this review, the core idea is to present the antifungal potential of the selected medicinal plant and its secondary metabolites against different fungal pathogens. Additionally, toxicological studies (safety profile) conducted on the amazing plant A. conyzoides L. are discussed for the possible clinical development of this medicinal herb. Articles available from 2000 to 2020 were reviewed in detail to exhibit recent appraisals of the antifungal properties of A. conyzoides. Efforts were aimed at delivering evidences for the medicinal application of A. conyzoides by using globally recognized scientific search engines and databases so that an efficient approach for filling the lacunae in the research and development of antifungal drugs can be adopted. After analyzing the literature, it can be reported that the selected medicinal plant effectively suppressed the growth of numerous fungal species, such as Aspergillus, Alternaria, Candida, Fusarium, Phytophthora, and Pythium, owing to the presence of various secondary metabolites, particularly chromenes, terpenoids, flavonoids and coumarins. The possible mechanism of action of different secondary metabolites of the plant against fungal pathogens is also discussed briefly. However, it was found that only a few studies have been performed to demonstrate the plant’s dosage and safety profile in humans. Considered all together, A. conyzoides extract and its constituents may act as a promising biosource for the development of effective antifungal formulations for clinical use. However, in order to establish safety and efficacy, additional scientific research is required to explore chronic toxicological effects of ageratum, to determine the probability of interactions when used with different herbs, and to identify safe dosage. The particulars presented here not only bridge this gap but also furnish future research strategies for the investigators in microbiology, ethno-pharmacology, and drug discovery. 相似文献
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Esra Korkmaz Kirakli Gökhan Takan Sinan Hoca F. Zümrüt Biber Müftüler Ayfer Yurt Kılçar Serra Arun Kamer 《Journal of Radioanalytical and Nuclear Chemistry》2018,315(3):595-602
The purpose of this study was to assess SPION’s in vitro radiosensitizer effect at 6MV-energies and to calculate nanoparticle enhancement ratio (NER) of SPIONs. Citrate coated-SPION’s were synthesized. Trypan-blue, metabolic activity tests were performed. Cell cultures were irradiated at 0,2,4,6,8 Gy at 6MV-energy. Clonogenic survival assays, NER calculations were carried out. SPIONs were biocompatible. NERs were cell-line specific and dose dependent. The highest radiosensitization were seen in radiosensitive MCF-7 and MDAH-2447 cells at 2 Gy (NER:1.49 and 1.39 respectively), in relatively radioresistant MDA-MB-231 cells at 4 Gy (NER:1.20). By increasing doses radiosensitizer effect disappeared. There is possibility that by synergistic effect, SPIONs may cause dose-dependent and cell-line specific radiosensitization at 6MV. 相似文献
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Carbon fiber (CF)‐based WO3/TiO2 composite catalysts (WO3/TiO2/CF) were successfully synthesized by solvothermal method. The catalysts were characterized by XPS, SEM, BET, XRD, FTIR, Raman and UV–Vis. The analyses confirmed the WO3/TiO2 nanoparticles with high crystallinity deposited on the carbon structure. The photocatalytic degradation of Orange II azo dye under UV and sunlight illumination with the synthesized catalyst was explored. The composite catalyst displayed high performance (85%) for Orange II degradation while that of for WO3/TiO2 was found as 76%. The effects of CF amount, solution pH, initial dye concentration and catalyst dose on photocatalytic performance were studied. It was found that the degradation efficiency increased from 68% to 90% with the increasing CF amount from 3 wt% to 5 wt%, while the further increase in CF amount (7–10 wt%) decreased the photodegradation due to the blocking the active sites of WO3/TiO2. The enhanced photocatalytic efficiency was mainly attributed to the electrical properties of the CF and reduced bandgap. 相似文献
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An efficient synthesis of 5-amino-7-aryl-3-oxo-8-(phenylsulfonyl)-thiazolo[3,2-a]pyridine-6-carbonitriles was conducted utilizing multicomponent condensation reaction of malononitrile, aromatic aldehydes and 2-phenylsulfonylmethylenethiazolidin-4-one in one pot. Depending on the equivalence of the aldehyde, two different products were obtained from moderate to excellent yields. Thirteen novel structures were characterized by physical and spectroscopic methods (m.p., Rf, IR, NMR and mass analysis). 相似文献
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Esra Imamoglu Meltem Conk Dalay Fazilet Vardar Sukan 《Applied biochemistry and biotechnology》2013,171(8):2065-2074
Agricultural by-products are becoming an attractive substrate for bioethanol production. The aim of this study was to evaluate the effects of regional differences in the rice hulls using Escherichia coli KO11 for bioethanol production. The rice hulls coded Edirne were obtained from Thrace Region, and the rice hulls coded Izmir were obtained from Aegean Region in Turkey. Rice hulls were treated by dilute acid before using them as substrates. The cells were incubated on an orbital shaker at 160 rpm under 30 °C during 96 h of the fermentation period. It was found that the maximum yield of ethanol from sugar (0.44 g ethanol/g reducing sugar) was obtained with the substrate C/N ratio of 29.16 in Izmir medium. The main difference was the dominant carbon source available as a substrate. It was detected that glucose concentration was about 2.5 times higher in Izmir medium, whereas xylose concentration was about two times higher in Edirne medium. The different results obtained with rice hulls from different origins could depend on the type of paddy as well as different cultivation conditions. These findings provide a valuable indicator for identifying suitable agricultural waste materials to be used as substrates for bioethanol production. 相似文献
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Four-component, one-pot condensation of dimedon, thiophene-2-carbaldehyde, ammonium acetate, and numerous acetophenones yielded novel 2-aryl-4-thionylquinoline derivatives. The structures were characterized by 1H NMR, 13C NMR, IR, and elemental analysis. 相似文献
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2-(2-Aminoethylamino)ethanol (L) reacts with cupric bromide in dimethylformamide to give a mononuclear complex of Cu(II) [L2Cu]Br2, with six-coordinate distorted octahedral geometry, in which two molecules of tridentate (N,N,O) ligand are involved. The structure was confirmed by spectroscopic methods, elemental and thermogravimetric analyses, and magnetic measurements. Optimization of possible configurations indicated the formation of the trans structure of the complex. Experimental results indicate that the investigated complex, bis[2-(2-aminoethylamino)ethanol] copper(II) bromide, behaves as a semiconductor in the studied temperature range of 298–388 K. Gas sensing properties of the film for the volatile organic compounds (VOCs): acetone, tetra-chloromethane, chloroform, ethanol, and methanol, were also investigated as a function of vapor concentration and temperature in dark. The film showed maximum sensitivity to tetrachloromethane and ethanol vapors at room temperature. Responses of the film to the tested gases are reversible. 相似文献