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Yancho Zarev Kenn Foubert Paul Cos Louis Maes Esameldin Elgorashi Sandra Apers 《Natural product research》2020,34(7):1037-1040
AbstractSeven tetracyclic spiro-alkaloids, i.e. glucoerysodine (1), erysodine (2), epi-erythratidine (3), erysovine (4), erythratidine (5), erysotrine (6) and erythraline (7) were isolated from the seeds of Erythrina latissima by means of conventional separation methods and HPLC-DAD-SPE-NMR. Their structures were elucidated by spectroscopic means. This is the first report on the isolation of compounds 3, 5 and 6 from this plant. Antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 and cytotoxicity against MRC-5 cells (human fetal lung fibroblast cells) was assessed in vitro. Erysodine (2) and erysovine (4) showed moderate activity (IC50 6.53?µM and 4.05?µM, respectively), compared with the standard chloroquine (IC50 = 0.14?µM). No cytotoxicity was observed in a concentration up to 64.0?µM. 相似文献
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