Three New Polyoxygenated Steroids from Two Species of the South China Sea Gorgonian Muricella flexuosa and Menella verrucosa Brundin

Three new polyoxygenated steroids, muricesteroid ( 1 ), and menellsteroids A ( 2 ) and B ( 3 ), were isolated from two species of the South China Sea gorgonian Muricella flexuosa and Menella verrucosa Brundin , respectively. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analysis, chemical methods and comparison with known related compounds.     

The first total syntheses of (±)-Preussomerins K and L using 2-arylacetal anion technology

The first syntheses of newly isolated members of the Preussomerin family, Preussomerins K and L, are reported. Key steps include the functionalisation of a 2-arylacetal anion, one-pot Friedel-Crafts cyclisation-deprotection and reductive opening of epoxides.     

Linearized Stability of Charged Thin-Shell Wormholes

The linearized stability of charged thin shell wormholes under spherically symmetric perturbations is analyzed. It is shown that the presence of a large value of charge provides stabilization to the system, in the sense that the constraints onto the equation of state are less severe than for non-charged wormholes.     

Long-Range proton-proton coupling constants. I. Propanic coupling involving a methyl group 4JMeH

An equation is formulated on the basis of theoretical INDO/FPT calculations which describes the angular dependence of the propanic long-range coupling constant ⁴J_MeH in substituted HCCCH₃ fragments. This equation is a truncated Fourier series in the torsion angle ?, HCCMe, which takes into account the dependence of the Fourier coefficients on the bond angle θ, CCMe. The substituent effects are assumed to be additive. Some parameters in the equation may be obtained from the ⁴J_MeH couplings in propane and neopentane derivatives. The calculated effect upon ⁴J_MeH of changes in the bond angle θ is significant and it seems to be in part the cause of some effects which have been attributed to conformational dependence.     

Comparison between structural and residual error formulations of an optimum design mechanism problem

Summary The model formulation of the objective function is one of the most important steps for solving an optimization problem. Generally, the objective function of an optimal design mechanism problem can be mathematically formulated either with structural or residual errors. In this paper we have conducted some comparisons between the results obtained by the structural and residual error formulations utilized in solving the optimum design of a four-bar linkage. The optimization problem is defined as a nonlinear least-squares problem. The damped Gauss-Newton algorithm is utilized for computing the solution, which ensures a local convergence for almost all nonlinear least-squares problems.

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Sommario La formulazione matematica della funzione obiettivo è uno degli aspetti più delicati nella soluzione di un problema di ottimizzazione. Generalmente la funzione obiettivo di un problema di progettazione ottima di un meccanismo può essere formulata sia mediante l'errore strutturale che residuo. In questo lavoro sono stati eseguiti dei confronti tra i risultati ottenuti mediante le due precedenti formulazioni, in riferimento al problema della progettazione ottima di un quadrilatero articolato. Il problema di ottimizzazione viene definito come un problema nonlineare ai minimi quadrati la cui soluzione numerica è ottenuta mediante l'algoritmo damped di Gauss-Newton.

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This paper was partially discussed at theII Congegno di Meccanica Computazionale, Roma, 1987.