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1.
The reaction of 2-(2-acetoxyethyl)amino-4-chloro-6-methylpyrimidine with aromatic amines leads to a series of 4-arylamino-2-(2-acetoxyethyl)amino-6-methylpyrimidines. Deacetylation of these compounds proceeds in both acidic and basic media. Most of the arylaminopyrimides obtained exhibit a pronounced antituberculous effect. 相似文献
2.
Russian Journal of Organic Chemistry - 2-[(2-Amino-6-methylpyrimidin-4-yl)sulfanyl]acetohydrazide reacted with triethyl orthoformate at a molar ratio of 1:1 to give... 相似文献
3.
Addition of 6-methyl-2-(3-methyl-5-oxo-2,5-dihydropyrazol-1-yl)pyrimidin-4(1H)-one, a compound with two CH-acidic centers, to 5-benzylidenepyrimidine-2,4,6(1H,3H,5H)-trione proceeds with the participation of the atom C5 of pyrimidine ring. Under the realized reaction conditions the latter possesses a greater nucleophilicity as a result of
the priority ionization. The obtained Michael adduct is unstable in the neutral aqueous medium and is decomposed into initial
oxopyrazolylpyrimidinone, pyrimidine-2,4,6-(1H,3H,5H)-trione, and benzaldehyde. 相似文献
4.
A. V. Erkin V. I. Krutikov E. B. Smirnova 《Russian Journal of General Chemistry》2008,78(10):1944-1948
2-Substituted 4-arylamino-6-methylpyrimidines were synthesized by stepwise modification of the structure of 6-methyl-2-thiouracyl through the intermediate 2-(ar)alkylthio-6-methyl-4-chloropyrimidines. Some of the compounds synthesized exhibit expressed antimycobacterial activity. 相似文献
5.
Electrophilic substitution of hydrogen in bicyclic 5-hydroxy-3-methyl-1-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-1H-pyrazole occurs exclusively at the C4 atom of the five-membered heteroring. Unstable electrophilic substitution products are stabilized via addition of the second
substrate molecule with formation of bridged adducts. 相似文献
6.
Polyfluoroalkyl esters of phosphoric, alkylphosphonic and 1-hydroxypolyfluoroalkylphosphonic acids exhibited significant antiesterase
activity against various esterases of animal and microbial origin. Moreover, with some compounds reversible inhibition of
enzymes was observed due to the specific influence of hydrophobic fragments of the target products. 相似文献
7.
A. V. Erkin V. V. Gurzhii I. V. Klaptyuk T. V. Firsanova V. I. Krutikov 《Russian Journal of General Chemistry》2017,87(3):402-406
Fusion 2-(4,6-dimethylpyrimidin-2-yl)-5-methyl-2Н-pyrazol-3-ol with phenols leads to the formation of complexes which exist due to a system of intermolecular N···H–O hydrogen bonds. The complexes are stable at high temperatures: their melting and subsequent thermolysis are accompanied by endothermic effects. 相似文献
8.
合成了7,8,17,18-四溴-5,10、15,20-四苯基卟啉钯金属配合物,通过电子光谱,元素分析,IR,^1H NMR测定,确定配合物的组成,同时经放氢功能研究证明该配合物具有光敏性。 相似文献
9.
Condensation of aminoguanidine hydrochloride and ethyl acetoacetate results in 2,3-diamino-6-methylpyrimidin-4(3H)-one, 5-hydroxy-1-carboxamidino-3-methylpyrazole or ethyl N-[(5-hydroxy-3-methylpyrazol-1-yl)imidoyl]aminocrotonoate depending on the type of the base. Formation of pyrazole derivatives occurs in the case of dequaternized substrate imine-group protonating by the acids formed as a result of ion exchange reaction. Chelate fragment of amidinohydroxypyrazole structure provides stabilization of this compound and stipulates its inertness towared the heterocycle closure. 相似文献
10.
In this paper, the control of chaos with a single controller, which provides simplicity in implementation, is investigated in continuous time nonlinear Rucklidge system. For this purpose, a linear feedback controller and a passive controller are constructed and added to the Rucklidge chaotic system. Lyapunov function is used to realize that the controller ensures the global asymptotic stability of the system. Owing to the controller, Rucklidge chaotic system can be regulated to its equilibrium points. Numerical simulations of the proposed methods and local relay control method have been demonstrated, compared and discussed. 相似文献