排序方式: 共有8条查询结果,搜索用时 31 毫秒
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K. Raghavendra Rao Akula Raghunadh Ramamohan Mekala Suresh Babu Meruva T.V. Pratap T. Krishna Dipak Kalita Eppakayala Laxminarayana Bagineni Prasad Manojit Pal 《Tetrahedron letters》2014
A dual reactant/catalyst role of glyoxylic acid in the reaction of isatoic anhydride with various amines afforded a novel, robust and rapid synthesis of 3-(un)substituted quinazolin-4(3H)-ones. This metal catalyst-free reaction proceeds via an unusual and unexpected cleavage of C–C bond. A shorter and common route to two alkaloids, that is, rutaecarpine and evodiamine is also accomplished. 相似文献
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Eppakayala Sreedhar R. Sateesh Chandra Kumar G. Venkateswar Reddy A. Robinson K. Suresh Babu J. Madhusudana Rao P.V. Srinivas 《Tetrahedron: Asymmetry》2009,20(4):440-448
A concise total synthesis of neohelmanticins A–D has been accomplished in 15 steps starting from commercially available gallic acid. Swern oxidation conditions, a Grignard reaction, Sharpless kinetic resolution, and regioselective ring opening of an epoxide with lithium aluminum hydride (LAH) are the key features to install the basic core, dihydroxy phenyl propane 2. One hydroxyl group of this core was esterified with tiglic acid followed by the oxidation and esterification with corresponding acids to yield neohelmanticins A–D. 相似文献
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Arramshetti Venkanna Eppakayala Sreedhar Bandi Siva Katragadda Suresh Babu Kothakonda Rajendra Prasad Janaswamy Madhusudana Rao 《Tetrahedron: Asymmetry》2013,24(17):1010-1022
The stereoselective synthesis of the macrolactone core of the natural product koshikalide is described. Starting with readily available 1,4-butanediol and malic acid as synthons, our synthetic strategy involved the reiterative application of Gilman’s reaction, Swern oxidation and Sharpless asymmetric epoxidation to establish the required stereocentres. Other key steps in the synthesis include Negishi cross coupling and Horner–Wadsworth–Emmons (HWE) reactions for construction of the main fragments. The 14-membered lactone ring was prepared by a selective Mitsunobu macrolactonization approach. 相似文献
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Kiran Devarasetty Giri Tharikoppula Tailor Sridhar Laxminarayana Eppakayala Mahesh Kyasani Premkumar Arumugam 《合成通讯》2016,46(3):263-274
A series of novel 2-alkylamino and 2, 4-dialkyl amino 6-oxopyrimidin-1(6H)-yl) benzamide derivatives were prepared in good yields from a base-catalyzed ring opening of oxadiazolo[3,2-a]pyrimidin-5-one and evaluated for their antibacterial and cytotoxicity. Most of the compounds exhibited antibacterial activity. In particular, compounds 5b and 5k exhibited considerable antibiotic activity against Klebsiella pneumonia and Bacillus cereus. In addition, compounds 5g and 5i also inhibited the growth of two human tumor cell lines (A549 and H460) at micromolar concentrations. 相似文献
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Synthesis of Novel Drug‐Like Small Molecules Based on Quinoxaline Containing Amino Substitution at C‐2 下载免费PDF全文
K. Raghavendra Rao Akula Raghunadh Ramamohan Mekala Suresh Babu Meruva K. Ravi Ganesh T. Krishna Dipak Kalita Eppakayala Laxminarayana Manojit Pal 《Journal of heterocyclic chemistry》2016,53(3):901-908
A series of novel “drug‐like” small molecules based on quinoxaline containing amino substitution at C‐2 were synthesized. All these molecules were prepared either via the reaction of 2‐phenyl‐3‐(piperazin‐1‐yl)quinoxaline with acyl bromides or benzyl bromides or various carboxylic acids or via the reaction of 2‐chloro‐3‐phenylquinoxaline with various amines. The structures of these novel compounds were confirmed by spectral analysis. The strategy used is simple and efficient and afforded good yields of quinoxaline derivatives. 相似文献
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Chakrapani Sanaboina Samaresh Jana Sridhar ChidaraBalaram Patro Gajendrasinh Balvantsinh RaoljiLaxminarayana Eppakayala 《Tetrahedron letters》2012,53(37):5027-5029
Synthesis of indole alkaloid related compounds using Schiff base formation, intramolecular cyclization (or N-alkylation), and Pictet-Spengler reaction as a cascade one pot condensation has been reported. The cascade chemistry has been applied to the synthesis of (±)-harmicine as a key step. 相似文献
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R. Sateesh Chandra Kumar Eppakayala Sreedhar G. Venkateswar Reddy K. Suresh Babu J. Madhusudana Rao 《Tetrahedron: Asymmetry》2009,20(10):1160-1163
The enantioselective synthesis of 2,6-cis-disubstituted piperidine alkaloids, (2R,6S)-isosolenopsin A 2 and (2S,6R)-isosolenopsin 5 from fire ant venom is described. Starting from the dodecanal and decanal, the synthesis presents two key steps. The first step involves Keck allylation to afford the chiral homoallylalcohol with the required stereochemistry and the second key step consists of Grubbs olefin cross metathesis. The synthesis was achieved in five steps with 44% overall yield. 相似文献
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Reddy Ganji Sreekanth Rao Anna Venkateswara Keshavulu Masula Viswanath I. V. Kasi Laxminarayana Eppakayala 《Russian Journal of General Chemistry》2022,92(9):1749-1760
Russian Journal of General Chemistry - A series of novel fluoroquinolone thiazolidinone derivatives were synthesized and evaluated for their biological activity. All the newly synthesized compounds... 相似文献
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