Research on five-membered heterocycles

Replacement of the nitro group in polynitroimidazoles by a halogen atom by the action of POBr₃ in dimethylformamide or by means of hydrohalic acids was studied. It is shown that the second method is the most convenient method in the preparation of chloro- and bromonitroimidazoles.See [1] for communication I.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1666–1668, December, 1977.     

Research on five-membered heterocycles

Nitrochloroimidazoles were synthesized by replacement of the nitro group in dinitroimidazoles by chlorine by the action of POCl₃. It is shown that in the case of 4,5-dinitroimidazoles substitution takes place when both dimethylformamide (DMF) and pyridine are used as the solvents, while only DMF is suitable for 2,4-dinitroimidazoles. The location of the halogen in the synthesized nitrochloroimidazoles was confirmed by alternative synthesis.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, May, 1977.