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Bodige S. Ravula P. Gulipalli K. Ch. Endoori S. Cherukumalli P. Koteswara Rao Chandra J. N. Narendra Sharath Seelam N. 《Russian Journal of General Chemistry》2020,90(7):1322-1330
Russian Journal of General Chemistry - A series of novel N-{2-fluoro-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)methyl]phenyl} carboxamide derivatives has been synthesized, and their molecular structures... 相似文献
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Srinu Bodige Parameshwar Ravula Kali Charan Gulipalli Srinivas Endoori Purna Koteswara Rao Cherukumalli Narendra Sharath Chandra JN 《合成通讯》2013,43(17):2219-2234
AbstractA novel series pyrrolo[3,2-b]pyridine-3-carboxamide linked 2-methoxypyridine derivatives have been designed, synthesized and confirmed by FT-IR, 1H NMR, 13C NMR, 19F NMR, MS, and elemental analysis. The synthesized compounds were screened for their antitubercular activity using microplate alamar blue assay method and antibacterial activity. Among the tested compounds, 4- fluorophenyl (8m), 4- chlorophenyl (8n) and 4-methoxyphenyl (8i) showed potent anti-TB activity (3.12?µg/mL) in comparison with reference drug, Pyrazinamide ((3.12?µg/mL). In addition, all compounds were docked into DprE1 (PDB code: 4KW5) to explore their binding interactions at the active site. The compounds exhibited essential key interactions as that of reported DprE1 inhibitors and hence, the synthesized compounds may be considered as molecular scaffolds for antitubercular activity. Compounds, 4-chlorophenyl (8n) and 4-flurophenyl (8m) showed significant antibacterial activity against Escherichia coli and Staphylococcus aureus strains. In silico prediction of toxicities, druglikeness and drug score profiles of the tested compounds are promising. 相似文献
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Endoori S. Gulipalli K. Ch. Bodige S. Seelam N. 《Russian Journal of Organic Chemistry》2019,55(9):1387-1393
Russian Journal of Organic Chemistry - A novel and highly efficient synthetic approach has been developed for the synthesis of deuterium-labeled olopatadine-d6 using inexpensive and commercially... 相似文献
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Endoori Srinivas anna Venkateswara Rao Gulipalli Kali Charan Bodige Srinu Pommidi Anil Kumar Surapureddi Sri Ramakrishna Seelam Nareshvarma 《Russian Journal of General Chemistry》2022,92(9):1775-1784
Russian Journal of General Chemistry - A novel series of imidazo[1,2-a]pyridine linked 1,2,3-triazole derivatives has been designed, synthesized and the structures have been confirmed by 1H and 13C... 相似文献
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Gulipalli K. C. Ravula P. Bodige S. Endoori S. Cherukumalli P. K. R. Narendra Sharath Chandra J. N. Seelam N. 《Russian Journal of General Chemistry》2019,89(7):1502-1512
Russian Journal of General Chemistry - A novel series of thiophene-2-carboxamide derivatives are designed and synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectra.... 相似文献
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Gulipalli K. Ch. Ravula P. Bodige S. Endoori S. Cherukumalli P. Koteswara Rao Chandra J. N. Narendra Sharath Seelam N. 《Russian Journal of General Chemistry》2020,90(7):1336-1344
Russian Journal of General Chemistry - A new series of urea and thiourea bearing thiophene-2-carboxalate derivatives has been designed against protein tyrosine phosphatase 1B (PTP1B) active site,... 相似文献
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Srinivas Endoori Kali Charan Gulipalli Srinu Bodige Parameshwar Ravula Nareshvarma Seelam 《Journal of heterocyclic chemistry》2021,58(6):1311-1320
A novel series of imidazo[1,2-a]pyridine based 1H-1,2,3-triazole derivatives were designed, synthesized, and evaluated for their anticancer activity against two different human cancer cell lines. Most of the synthesized compounds displayed anticancer activity with IC50 values from 2.35 to 120.46 μM. Furthermore, compounds 9b , 9c, 9d, 9f , and 9j showed potent inhibitory activity against cancer cell lines, with IC50 values close to that of standard drug. It is important to note that compound 9d was more potent than the standard drug cisplatin with IC50 values of 10.89 and 2.35 μM against Hela cell line and MCF-7 cell line, respectively. 相似文献
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