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1.
Bhaskar M Gnanamani A Ganeshjeevan RJ Chandrasekar R Sadulla S Radhakrishnan G 《Journal of chromatography. A》2003,1018(1):117-123
Extracellular fluid protein (ECFP) of Streptomyces species SS07 has been used to reduce water soluble azo dyes and the carcinogenic amines released have been compared with that from chemical reduction. The effect of temperature, pH and contact time on the recovery of amines using ECFP was studied. The ECFP releases carcinogenic amines at a pH of 9.2 and a temperature of 37 degrees C for a contact period of 24 h. The reduction products were analyzed with HPLC and their structures confirmed by LC-MS and GC-MS. It was observed that both the ECFP and chemical reduction methods released similar type of amine products. In the case of dye samples, compared to chemical reduction, 5-20% increase in the release of carcinogenic amines by ECFP was observed. The percentage of amine products released by chemical reduction was higher for leather garment samples compared to ECFP treatment. 相似文献
2.
[Cp∗IrCl2]2 catalyses the cyclization of 2-alkynylanilines into indoles. A wide variety of substrates is tolerated. A reaction pathway involving intramolecular hydroamination is proposed. 相似文献
3.
Brindha Elumalai Aruna Prakasarao Bharanidharan Ganesan Koteeswaran Dornadula Singaravelu Ganesan 《Journal of Raman spectroscopy : JRS》2015,46(1):84-93
Urine is considered as one of the diagnostically important bio fluids, as it has many metabolites. The distribution and the physiochemical properties of the metabolites may vary during any altered metabolic and pathological conditions. Raman spectroscopy was employed in the characterization of the metabolites of human urine of normal subjects and oral cancer patients in the finger print region (500–1800 cm−1). Principal component analysis‐based linear discriminant analysis was performed to discriminate cancer patients from normal subjects. The discriminant analysis classifies the cancer patients from normal subjects with a sensitivity and specificity of 98.6% and 87.1%, respectively, with an overall accuracy of 93.7%. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
4.
Khadhar Navaz Umar Basha Shanthi Gnanamani Prakash Shanmugam Sujatha Venugopal Sangeetha Murthy Balagurunathan Ramasamy 《Journal of heterocyclic chemistry》2021,58(10):2000-2008
A simple and convenient method for the one-pot synthesis of 3-(1H-indole-3-carbonyl)-2H-chromen-2-one derivatives from the reaction of 3-cyanoacetyl indole and salicylaldehyde in the presence of Na2CO3 in water: methanol (1:1) is described. Wider substrate scope, high yields, operational simplicity, and simple purification process make the protocol highly applicable in the synthesis of 3-(1H-indole-3-carbonyl)-2H-chromen-2-ones. For the first time, in vitro antioxidant and antimicrobial activity was studied. Compounds 5e , 7a , and 7b exhibits good radical scavenging ability against DPPH free radical. Compounds 7b , 5f , and 5g possess lower EC50 values than the Standards AA and BHA and thus proving their high reducing power. Compounds 5d and 5f show good antibacterial activity against gram-positive bacteria (MRSA) while compounds 5c , 7a , and 7b exhibits good antibacterial activity against Bacillus sp. Compounds 5b and 5e show good antibacterial activity against gram negative bacterial strains (Escherichia coli, Klebsiella pneumoniae) and compounds 5g and 5h exhibits good antifungal activity against Candida albicans. 相似文献
5.
Karuppan Venkatapathy Chinnaiyan J. Magesh Gnanamani Lavanya Paramasivam T. Perumal Sekar Prema 《Journal of heterocyclic chemistry》2020,57(4):1936-1955
In the present study, we report the design and eco-benign synthesis of new class of carbazolyl-1,4-dihydropyridine (1,4-CDHP) and carbazolyl-1,8-dioxodecahydroacridine (CAD) derivatives via a three-component coupling reaction of substituted carbazole aldehydes, ethyl acetoacetate/dimedone, and ammonium acetate under solvent-free conditions at 112°C to 115°C. We also report an efficient one-pot synthesis of new class of carbazolyl polyhydroquinoline (CPQ) derivatives via a four-component coupling reaction of substituted ethyl acetoacetate, dimedone, ammonium acetate, and carbazole aldehydes in acetonitrile/water medium (3:1) at 73°C to 75°C in moderate yields. All the products were thoroughly characterized by 1H NMR, 13C NMR, Fourier transform infrared (FTIR), mass spectral, and CHN analysis. The synthesized heterocyclic compounds were evaluated for their in vitro antibacterial activity against pathogenic strains of both Gram-negative and Gram-positive bacteria. Minimum inhibitory concentration (MIC) of the active compounds was evaluated by macrodilution method. The CPQ derivative ( 8a ) displayed superior antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhi with the MIC values of 16.0 to 32.0 μg/mL in comparison with the reference drug. The mechanism of antibacterial action of the CPQ derivatives was investigated via scanning electron microscope (SEM) studies. The molecular docking studies indicate that the CPQ derivative ( 8a ) binds to the cell wall protein of E coli and P aeruginosa by formation of hydrogen bonds with amino acid residues (TYR328 and GLU249) of the bacterial cell wall protein. The 1,4-CDHP, CAD, and CPQ derivatives were either noncytotoxic or exhibited minimal cytotoxicity towards human mononuclear cells from peripheral blood. All the products were evaluated for Lipinski rule of five (RO5) and were found to have good oral bioavailability. 相似文献
6.
Simultaneous Delamination and Rutile Formation on the Surface of Ti3C2Tx MXene for Copper Adsorption
In this work, we studied the formation of the rutile phase of titanium dioxide (TiO2) on delaminated MXene (d‐Ti3C2Tx) flakes by the reaction of Ti3C2Tx with amino acids in water. Three types of amino acids with varied side‐chain polarity were used to delaminate Ti3C2Tx. d‐Ti3C2Tx flakes formed stable colloidal solutions due to the negative surface charges of chemisorbed amino acids on the d‐Ti3C2Tx. Rutile formed on d‐Ti3C2Tx at room temperature upon the intercalation of aromatic amino acids and subsequent sonication of the solution, while flakes intercalated with aliphatic amino acids did not oxidize. X‐Ray diffraction (XRD), transmission electron microscopy (TEM) and Raman spectroscopy revealed the nanosize rutile formation on the surface of Ti3C2Tx flakes. The XPS results indicated the surface functionalization of histidine on d‐Ti3C2Tx flakes. As‐synthesized histidine functionalized rutile TiO2@d‐Ti3C2Tx hybrid was used for adsorption of Cu2+ ions from aqueous solution with a maximum uptake of 95 mg g?1. 相似文献
7.
Gnanamani Shanthi 《Tetrahedron letters》2008,49(50):7139-7142
An InCl3 catalyzed efficient synthesis of novel dispiro[cyclopent-3′-ene]bisoxindoles is accomplished via a one-pot reductive cyclization of isatylidene malononitriles using the Hantzsch ester. 相似文献
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9.
Tapas Mitra G. Sailakshmi A. Gnanamani A. B. Mandal 《Journal of Thermal Analysis and Calorimetry》2011,105(1):325-330
This study emphasizes, cross-linking potential of a simple di-carboxylic acid, namely, oxalic acid with type I collagen for
the preparation of collagen based biomaterial for clinical applications. Further the study discusses the characteristics features
of the cross-linked material in comparison with the standard cross-linker. In addition, the study also demonstrates the role
of ionic interactions in providing the thermal stability and tensile strength to the cross-linked biopolymer material. Type
I collagen from rat tail tendon treated with oxalic acid at optimized concentrations provided a biopolymer material without
changing the triple helical pattern of collagen (CD spectrum) and also with 6–7 fold increase in tensile strength than native
collagen. FTIR spectral details demonstrate the ionic interactions between collagen and oxalic acid. Thermal stability analyses
of oxalic acid cross-linked biopolymer revealed, high thermal stability compared to materials of glutaraldehyde cross-linked.
The results of the study suggest oxalic acid as a suitable cross-linker for collagen and it cross-link with collagen through
ionic interactions. 相似文献
10.
Vladimir V. Plashnitsa Taro Ueda Perumal Elumalai Toshikazu Kawaguchi Norio Miura 《Ionics》2008,14(1):15-25
The nanostructured thin NiO films with the thicknesses of 30–180 nm were examined as a sensing electrode (SE) for the planar
mixed-potential-type yttria-stabilized zirconia (YSZ)-based NO2 sensor. The sensing characteristics were examined in the temperature range of 600–800 °C under the wet condition (5 vol.%
water vapor). Among the NiO-SEs tested, the 60 nm-thick NiO-SE sintered at 1,000 °C was found to give the highest NO2 sensitivity in the NO2 concentration range of 50–400 ppm accompanying with fast response/recovery at the operating temperatures of 600–700 °C. The
high NO2 sensitivity was attributed to the high catalytic activity for both electrochemical reactions of O2 and NO2 at the interface of NiO-SE/YSZ. The ultrathin gold layer with the thickness of about 60 nm was additionally formed on the
60 nm-thick NiO-SE to fabricate the laminated-type (60 nm NiO/60 nm Au)-SE. It was demonstrated that the use of this laminated
(NiO–Au)-SE improved both the sensitivity and the selectivity to NO2. 相似文献