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Selected natural products have long been considered as desirable targets for total synthesis due to their unique biological properties and their challenging structural complexity. Laboratory synthesis of natural compounds usually relies on target-oriented synthesis, involving the production, isolation and purification of successive intermediates, requiring multiple steps to arrive to the final product. A far more economical approach using common synthetic scaffolds that can be readily transformed through biomimetic-like pathways to a range of structurally diverse natural products has been evolved in the last decade, leading synthesis to new directions. This tutorial review critically presents the hallmarks in this field. 相似文献
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Efthymia G. Gioti Theocharis V. Koftis Efstratios Neokosmidis Elli Vastardi Stefanos S. Kotoulas Sakellarios Trakossas Theodoros Tsatsas Elizabeth E. Anagnostaki Theodoros D. Panagiotidis Constantinos Zacharis Evanthia P. Tolika Anastasia-Aikaterini Varvogli Thanos Andreou John K. Gallos 《Tetrahedron》2018,74(4):519-527
A new synthesis of entecavir from d-glucose in an average total yield of 3.5% was achieved via an intramolecular nitrile oxide cycloaddition (INOC) reaction and a Peterson olefination as key-steps. The present process was designed for industrial application, using widely available raw materials, simple and cheap reagents and avoiding low reaction temperatures, which are very common in the synthetic approaches towards similarly complex structures. 相似文献
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