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1.
Eder J. Lenardão Luiz G. Dutra Maiara T. Saraiva Raquel G. Jacob Gelson Perin 《Tetrahedron letters》2007,48(45):8011-8013
A general and easy method for the synthesis of several vinyl selenides using NaBH4 and BMIMBF4 as a recyclable solvent is described. This efficient and improved method furnishes the corresponding vinyl chalcogenides preferentially with Z configuration. We also observed that when the same protocol was applied to phenyl acetylene, (E)-bis-phenylseleno styrene was obtained in good yield and with high selectivity. 相似文献
2.
The relativistic mean-field models tested in previous works against nuclear matter experimental values,critical parameters and macroscopic stellar properties are revisited and used in the evaluation of the symmetry energyγ parameter obtained in three different ways. We have checked that, independent of the choice made to calculate theγ values, a trend of linear correlation is observed between γ and the symmetry energy(S_0) and a more clear linear relationship is established between γ and the slope of the symmetry energy(L_0). These results directly contribute to the arising of other linear correlations between γ and the neutron star radii of R_(1.0) and R_(1.4), in agreement with recent findings. Finally, we have found that short-range correlations induce two specific parametrizations, namely,IU-FSU and DD-MEδ, simultaneously compatible with the neutron star mass constraint of 1.93≤M_(max)/M_☉≤2.05 and with the overlap band for the L_0 ×S_0 region, to present γ in the range of γ=0.25±0.05. 相似文献
3.
In this work we group four research topics apparently disconnected, namely solitons, Lorentz symmetry breaking, supersymmetry, and entropy. Following a recent work (Gleiser and Stamatopoulos, 2012), we show that it is possible to construct in the context of travelling wave solutions a configurational entropy measure in functional space, from the field configurations. Thus, we investigate the existence and properties of travelling solitons in Lorentz and CPT breaking scenarios for a class of models with two interacting scalar fields. Here, we obtain a complete set of exact solutions for the model studied which display both double and single-kink configurations. In fact, such models are very important in applications that include Bloch branes, Skyrmions, Yang–Mills, Q-balls, oscillons and various superstring-motivated theories. We find that the so-called Configurational Entropy (CE) for travelling solitons shows that the best value of parameter responsible to break the Lorentz symmetry is one where the energy density is distributed equally around the origin. In this way, the information-theoretical measure of travelling solitons in Lorentz symmetry violation scenarios opens a new window to probe situations where the parameters responsible for breaking the symmetries are arbitrary. In this case, the CE selects the best value of the parameter in the model. 相似文献
4.
Maria Luiza Zeraik Ivani Pauli Luiz A. Dutra Raquel S. Cruz Marilia Valli Luana C. Paracatu Carolina M. Q. G. de Faria Valdecir F. Ximenes Luis O. Regasini Adriano D. Andricopulo Vanderlan S. Bolzani 《Molecules (Basel, Switzerland)》2021,26(8)
Cyclooxygenase (COX) and lipoxygenase (LOX) are key targets for the development of new anti-inflammatory agents. LOX, which is involved in the biosynthesis of mediators in inflammation and allergic reactions, was selected for a biochemical screening campaign to identify LOX inhibitors by employing the main natural product library of Brazilian biodiversity. Two prenyl chalcones were identified as potent inhibitors of LOX-1 in the screening. The most active compound, (E)-2-O-farnesyl chalcone, decreased the rate of oxygen consumption to an extent similar to that of the positive control, nordihydroguaiaretic acid. Additionally, studies on the mechanism of the action indicated that (E)-2-O-farnesyl chalcone is a competitive LOX-1 inhibitor. Molecular modeling studies indicated the importance of the prenyl moieties for the binding of the inhibitors to the LOX binding site, which is related to their pharmacological properties. 相似文献
5.
Beatriz Werneck Lopes Santos Daniel Carneiro Moreira Tatiana Karla dos Santos Borges Eloisa Dutra Caldas 《Molecules (Basel, Switzerland)》2022,27(8)
Banisteriopsis caapi is used to prepare the psychoactive beverage ayahuasca, and both have therapeutic potential for the treatment of many central nervous system (CNS) conditions. This study aimed to isolate new bioactive compounds from B. caapi extract and evaluate their biological activity, and that of the known β-carboline components of the plant (harmine, harmaline, and tetrahydroharmine), in BV-2 microglial cells, the in vivo activation of which is implicated in the physiopathology of CNS disorders. B. caapi extract was fractionated using semipreparative liquid chromatography (HPLC-DAD) and the exact masses ([M + H]+ m/z) of the compounds in the 5 isolated fractions were determined by high-resolution LC-MS/MS: F1 (174.0918 and 233.1289), F2 (353.1722), F3 (304.3001), F4 (188.1081), and F5 (205.0785). Harmine (75.5–302 µM) significantly decreased cell viability after 2 h of treatment and increased the number of necrotic cells and production of reactive oxygen species at equal or lower concentrations after 24 h. F4 did not impact viability but was also cytotoxic after 24 h. Most treatments reduced proinflammatory cytokine production (IL-2, IL-6, IL-17, and/or TNF), especially harmaline and F5 at 2.5 µM and higher concentrations, tetrahydroharmine (9.3 µM and higher), and F5 (10.7 µM and higher). The results suggest that the compounds found in B. caapi extract have anti-inflammatory potential that could be explored for the development of treatments for neurodegenerative diseases. 相似文献
6.
In this work we present a mapping between the classical solutions of the sine-Gordon, Liouville, 4 and other kinks in 1+1 dimensions. This is done by using an invariant quantity which relates the models. It is easily shown that this procedure is equivalent to that used to get the so called deformed solitons, as proposed recently by Bazeia et al. [Phys. Rev. D. 66 (2002) 101701(R)]. The classical equivalence is explored in order to relate the solutions of the corresponding models and, as a consequence, try to get new information about them. We discuss also the difficulties and consequences which appear when one tries to extend the deformation in order to take into account the quantum version of the models. 相似文献
7.
Combination of hollow‐fiber‐supported liquid membrane and dispersive liquid–liquid microextraction as a fast and sensitive technique for the extraction of pesticides from grape juice followed by high‐performance liquid chromatography
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Vanessa Dutra Silva Vanessa Simão Adriana Neves Dias Jeferson Schneider Carletto Eduardo Carasek 《Journal of separation science》2015,38(11):1959-1968
The simultaneous use of a hollow‐fiber‐supported liquid membrane and dispersive liquid–liquid microextraction for the determination of pesticides directly in grape juice was investigated. The detection and quantification were performed by liquid chromatography with diode array detection. The optimum extraction condition was reached by filling the pores of the membrane wall with dodecanol and using hexane/acetone as extraction/dispersion solvents. Salt addition had a highly negative effect on the extraction efficiency and the optimum extraction time was 60 min. The volume of hexane/acetone mixture and the sample pH did not affect the signal at the levels studied. Therefore, an intermediate amount of these solvents (250 μL; 1:7.5 v/v) and pH 6 were selected. The optimum desorption condition was obtained with acetonitrile and 10 min of desorption time. The linear working range varied from 58 to 500 μg/L (parathion‐methyl), 62–500 μg/L (difenoconazole) and 107–500 μg/L (chlorpyrifos), with correlation coefficients ranging from 0.9980–0.9942. The limits of detection and quantification found were, respectively, 17 and 58 μg/L for parathion‐methyl, 19 and 62 μg/L for difenoconazole and 32 and 107 μg/L for chlorpyrifos. The relative standard deviation ranged between 3.5 and 11.2%. 相似文献
8.
9.
Araújo MJ Mattar NS Reis AS Serra IC Fialho EM Assunção AK Dutra RP Nogueira AM Libério SA Guerra RN Lopes AS Ribeiro MN Nascimento FR 《Natural product research》2011,25(11):1037-1046
The propolis of Scaptotrigona aff. postica is popularly used in Maranh?o State, Brazil, for treating wounds and respiratory illnesses. Nevertheless, little is known about the chemical composition of this propolis and the adverse effects of its use. Hence, this study is a pharmacognostic characterisation of the propolis hydroalcoholic extract (PHE) from S. aff. postica. The methodology consisted of an evaluation of the sensory and chemical parameters. Chemical analysis of PHE indicated high concentrations of phenolic and triterpens substances, and the absence of steroids. Additionally, we evaluated the acute toxicity of propolis using 48 Swiss male and female mice. The animals received single doses of PHE (1000, 2000 or 4000 mg kg?1) orally and were observed for 14 days. After this period, the mice were sacrificed and the blood was used for biochemical and haematological evaluation. PHE did not induce any death, and the acute treatment significantly reduced serum concentrations of alanine aminotransferase and alkaline phosphatase. The resultant data indicate that PHE from S. aff. postica has low toxicity when used orally, even in high doses. 相似文献
10.
Determination of the geographical origin of Brazilian wines by isotope and mineral analysis 总被引:1,自引:0,他引:1
Dutra SV Adami L Marcon AR Carnieli GJ Roani CA Spinelli FR Leonardelli S Ducatti C Moreira MZ Vanderlinde R 《Analytical and bioanalytical chemistry》2011,401(5):1575-1580
In the present research, we studied wines from three different south Brazilian winemaking regions with the purpose of differentiating
them by geographical origin of the grapes. Brazil's wide territory and climate diversity allow grape cultivation and winemaking
in many regions of different and unique characteristics. The wine grape cultivation for winemaking concentrates in the South
Region, mainly in the Serra Gaúcha, the mountain area of the state of Rio Grande do Sul, which is responsible for 90% of the
domestic wine production. However, in recent years, two new production regions have developed: the Campanha, the plains to
the south and the Serra do Sudeste, the hills to the southeast of the state. Analysis of isotopic ratios of 18O/16O of wine water, 13C/12C of ethanol, and of minerals were used to characterize wines from different regions. The isotope analysis of δ18O of wine water and minerals Mg and Rb were the most efficient to differentiate the regions. By using isotope and mineral
analysis, and discrimination analysis, it was possible to classify the wines from south Brazil. 相似文献