全文获取类型
收费全文 | 159篇 |
免费 | 3篇 |
专业分类
化学 | 82篇 |
力学 | 1篇 |
数学 | 5篇 |
物理学 | 74篇 |
出版年
2021年 | 3篇 |
2020年 | 3篇 |
2019年 | 3篇 |
2017年 | 2篇 |
2016年 | 6篇 |
2014年 | 2篇 |
2013年 | 9篇 |
2012年 | 5篇 |
2011年 | 8篇 |
2010年 | 5篇 |
2009年 | 5篇 |
2008年 | 7篇 |
2007年 | 3篇 |
2006年 | 6篇 |
2005年 | 3篇 |
2004年 | 9篇 |
2003年 | 2篇 |
2002年 | 1篇 |
2001年 | 1篇 |
2000年 | 5篇 |
1999年 | 6篇 |
1998年 | 2篇 |
1996年 | 7篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 5篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 7篇 |
1981年 | 3篇 |
1980年 | 5篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1974年 | 4篇 |
1967年 | 1篇 |
1966年 | 1篇 |
1962年 | 1篇 |
1959年 | 2篇 |
1958年 | 2篇 |
1956年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有162条查询结果,搜索用时 15 毫秒
1.
Prof. Dr. Francisco Melo Leonardo Caballero Esteban Zamorano Natalia Ventura Camilo Navarro Irving Doll Prof. Dr. Pedro Zamorano Prof. Dr. Alberto Cornejo 《Chemphyschem》2021,22(6):526-532
Parkinson's disease is a neurodegenerative disorder involving a functional protein, α-synuclein, whose primary function is related to vesicle trafficking. However, α-synuclein is prone to form aggregates, and these inclusions, known as Lewy bodies, are the hallmark of Parkinson's disease. α-synuclein can alter its conformation and acquire aggregating capacity, forming aggregates containing β-sheets. This protein's pathogenic importance is based on its ability to form oligomers that impair synaptic transmission and neuronal function by increasing membrane permeability and altering homeostasis, generating a deleterious effect over cells. First, we establish that oligomers interfere with the mechanical properties of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) membrane, as demonstrated by nanoindentation curves. In contrast, nanoindentation revealed that the α-synuclein monomer's presence leads to a much more resistant lipid bilayer. Moreover, the oligomers’ interaction with cell membranes can promote lactate dehydrogenase (LDH) release, suggesting the activation of cytotoxic events. 相似文献
2.
3.
Alexopoulos T Allen C Anderson EW Areti H Banerjee S Beery PD Biswas NN Bujak A Carmony DD Carter T Cole P Choi Y De Bonte RJ Erwin AR Findeisen C Goshaw AT Gutay LJ Hirsch AS Hojvat C Kenney VP Lindsey CS LoSecco JM McMahon T McManus AP Morgan N Nelson KS Oh SH Piekarz J Porile NT Reeves D Scharenberg RP Stampke SR Stringfellow BC Thompson MA Turkot F Walker WD Wang CH Wesson DK 《Physical review letters》1990,64(9):991-994
4.
Lazarus EA Navratil GA Greenfield CM Strait EJ Austin ME Burrell KH Casper TA Baker DR DeBoo JC Doyle EJ Durst R Ferron JR Forest CB Gohil P Groebner RJ Heidbrink WW Hong R Houlberg WA Howald AW Hsieh C Hyatt AW Jackson GL Kim J Lao LL Lasnier CJ Leonard AW Lohr J La Haye RJ Maingi R Miller RL Murakami M Osborne TH Perkins LJ Petty CC Rettig CL Rhodes TL Rice BW Sabbagh SA Schissel DP Scoville JT Snider RT Staebler GM Stallard BW Stambaugh RD St John HE Stockdale RE Taylor PL Thomas DM 《Physical review letters》1996,77(13):2714-2717
5.
6.
Instability of the paramagnetic state towards incommensurate magnetic order in the 2-d Hubbard model
K. Doll M. Dzierzawa R. Frésard P. Wölfle 《Zeitschrift für Physik B Condensed Matter》1993,90(3):297-300
We determine the instability line separating the paramagnetic phase in the phase diagram of the 2-d Hubbard Model from a phase with incommensurate magnetic order. A mean-field approximation of the Kotliar-Ruckenstein slave boson representation is used to calculate the wave-vector dependent magnetic susceptibility. For largeU/t the instability occurs at a densityn0.37, and a wave-vector close toq=(0,). The dependence ofq onU andn is also given. 相似文献
7.
8.
The preparation of a key tricyclic intermediate for the eventual total synthesis of the alkaloids gelsemicine and gelsedine is described. 相似文献
9.
During the examination of extracts from Oncinotis tenuiloba STAPF a new polyamine, N4-benzoylsperimidine ( 8 ), was isolated. For unambiguous structure elucidation, it was transformed into the diacetyl derivative 13 , and the three possible N-benzoyl-substituted isomers of spermidine 5, 8 , and 11 together with their peracetylated derivatives 12–14 , respectively, were synthesized and identified. 相似文献
10.
We present studies of the potential energy landscape of selected binary Lennard-Jones 13 atom clusters. The effect of adding selected impurity atoms to a homogeneous cluster is explored. We analyze the energy landscapes of the studied systems using disconnectivity graphs. The required inherent structures and transition states for the construction of disconnectivity graphs are found by combination of conjugate gradient and eigenvector-following methods. We show that it is possible to controllably induce new structures as well as reorder and stabilize existing structures that are characteristic of higher-lying minima. Moreover, it is shown that the selected structures can have experimentally relevant lifetimes. 相似文献