Methylsulfonyl benzothiazole (MSBT): a selective protein thiol blocking reagent

A new thiol blocking reagent, methylsulfonyl benzothiazole, was discovered. This reagent showed good selectivity and high reactivity for protein thiols.     

Morphological Transition of Schooling in 19th-Century France

The transformation over time of level sets—the sets of states for which a given function takes a given value—has no reason to be regular, especially in social science, where the structure of these level sets of a given variable may be altered by a fluctuating demography or disrupted by unexpected events, and where the actors contribute to shaping their space through investment policies. The pioneering construction of graphic derivatives of set-valued maps renews the understanding of dynamic level sets in social science. The exemplary case of schooling in 19th-century France shows the set derivatives of level sets and illustrates how the Franco-Prussian War of 1870–1871 disturbed the directions taken in 1867. A comparison of the observed changes of level sets with those observed under rational theoretical policies leads to the conclusion that the actors behaved with the ambition of optimizing the overall schooling incidence while reducing the gap between boys and girls.     

Facile amide formation via S-nitrosothioacids

Here we report a novel amide bond formation strategy from simple thioacid and amine starting materials. The reaction is mediated by unstable but very reactive S-nitrosothioacid intermediates. This fast reaction under mild conditions should be useful in synthesis.     

Solvent-controlled Csp2-->O silyl migration: the "one-pot" synthesis of 2,3-disubsituted thiophenes

An effective "one-pot" synthesis of disubstituted thiophene derivatives employing 3-bromo-2-silyl thiophenes has been developed. A solvent-controlled [1,4] Csp2-->O silyl migration was involved as the key step in this process.     

One-pot thioether formation from S-nitrosothiols

Protein S-nitrosation is an important post-translational modification. However, the detection of S-nitrosation is still problematic because S-nitrosation products, that is, S-nitrosothiols, are unstable species. Here a new reaction which can selectively convert unstable S-nitrosothiols to stable thioethers in one-pot under very mild conditions is reported. This reaction has the potential to be applied in the detection of protein S-nitrosation.     

中西医结合治愈脊髓蛛网膜炎1例

用中西医结合治疗脊髓蛛网膜炎1例,取得满意效果,并总结了治疗体会。