排序方式: 共有18条查询结果,搜索用时 31 毫秒
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Alireza Dastan Elisabetta A. Matsumoto William J. Frith 《Molecular physics》2018,116(21-22):2823-2835
ABSTRACTHierarchical self-assembly underpins much of the diversity of form and function seen in soft systems, yet the pathways by which they achieve their final form are not always straightforward – intermediate steps, kinetic effects and finite sizes of aggregates all influence the self-assembly pathways of these systems. In this paper, we use molecular dynamics simulations of binary mixtures of spheres and ellipsoidal discs to investigate the self-assembly of anisotropic aggregates with internal structures. Through this, the full aggregation pathways of spontaneously chiral, multi-bilayer and multi-layer assemblies have been tracked and characterised via a semi-qualitative analysis. This includes the unambiguous identification of first-, second- and third-generation hierarchical assemblies within a single simulation. Given the significant challenge of tracking full aggregation pathways in experimental systems, our findings strongly support the notion that molecular simulation has much to contribute to improving our understanding of hierarchical self-assembling systems. 相似文献
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Safar Ausama Abdulwahab Javan Sara Ghaderi Hiva Dastan Dara 《Chemistry of Natural Compounds》2022,58(3):565-566
Chemistry of Natural Compounds - 相似文献
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Ebadi Ahmad Dastan Dara Azami Mojtaba Karimi Adibe Razzaghi-Asl Nima 《Structural chemistry》2017,28(3):849-857
Structural Chemistry - Chemokine receptor 2 (CCR2), a G-protein coupled receptor (GPCR), is a critical target for several inflammatory and autoimmune diseases. The main restriction on designing... 相似文献
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Synthesis of Some Novel Norbornene‐Fused Pyridazines as Potent Inhibitors of Carbonic Anhydrase and Acetylcholinesterase
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Ramazan Kocak Esra Turan Akın Pınar Kalın Oktay Talaz Nurullah Saracoglu Arif Dastan Ilhami Gülcin Serdar Durdagi 《Journal of heterocyclic chemistry》2016,53(6):2049-2056
The reaction of benzocyclic norbornene derivatives with tetrazines provided the 1,3‐dihydropyridazine derivatives as a single product. The dihydropyridazine derivatives have been dehydrogenated with phenyliodine bis(trifluoroacetate) to yield the corresponding pyridazines in a high yield. Two stable diazines, primary product of corresponding 1,4‐dihydropyridazine, were also isolated. Structures were then determined by 1H‐NMR, and 13C‐NMR beside to elemental analyses. The novel pyridazine derivatives ( 8 , 9 ) efficiently inhibited the cytosolic human carbonic anhydrase isoenzymes I and II (hCA I and II). In addition, these novel pyridazine derivatives ( 8 , 9 ) were evaluated for their in vitro acetylcholinesterase inhibitory activity. Ligand–receptor interactions are tested using molecular docking simulations. Obtained docking scores are in good agreement with in vitro results. 相似文献
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Trapping of Organophosphorus Chemical Nerve Agents in Water with Amino Acid Functionalized Baskets
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Yian Ruan Erdin Dalkiliç Paul W. Peterson Aroh Pandit Prof. Arif Dastan Jason D. Brown Shane M. Polen Prof. Christopher M. Hadad Prof. Jovica D. Badjić 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(15):4251-4256
We prepared eleven amino‐acid functionalized baskets and used 1H NMR spectroscopy to quantify their affinity for entrapping dimethyl methylphosphonate (DMMP, 118 Å3) in aqueous phosphate buffer at pH=7.0±0.1; note that DMMP guest is akin in size to chemical nerve agent sarin (132 Å3). The binding interaction (Ka) was found to vary with the size of substituent groups at the basket′s rim. In particular, the degree of branching at the first carbon of each substituent had the greatest effect on the host‐guest interaction, as described with the Verloop′s B1 steric parameter. The branching at the remote carbons, however, did not perturb the encapsulation, which is important for guiding the design of more effective hosts and catalysts in future. 相似文献
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The transition metal-free coupling reactions of unactivated diazanaphthalenes were studied using only lithium tetramethylpiperidine (LiTMP) reagent. Symmetrical and nonsymmetrical bis-diazanaphthalenes were synthesized in moderate to high yield by homo- and cross-coupling of related monomers. In addition, the single-step synthesis of diquinoxalino [2,3-a: 2', 3'c] phenazine and 2,2': 3', 2″ - terquinoxaline using the appropriate equivalent amount of LiTMP was performed. The products were characterized by means of NMR spectroscopy and HRMS spectrometry. 相似文献
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F. Altaf S. Ahmed D. Dastan R. Batool Z.U. Rehman Z. Shi M.U. Hameed P. Bocchetta K. Jacob 《Materials Today Chemistry》2022
Methanol permeation is the main issue of Nafion membranes when they are used as a polymer electrolyte membrane (PEM) in direct methanol fuel cells (DMFCs). In the current study, novel nanocomposite polymer membranes are prepared by the integration of surface-modified sepiolite (MS) in polyvinylidene fluoride grafted polystyrene (PVDF-g-PS) copolymer as PEM in DMFCs. Sepiolite (SP) surface is chemically modified using vinyltriethoxysilane and analyzed by Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM). Nanocomposite PVDF-g-PS/MS membranes are prepared by phase inversion technique and subsequently treated with chlorosulfonic acid to induce sulfonic acid (SO3H) active sites at the membrane surface. The prepared nanocomposite membranes (S-PPMS) are analyzed for their physicochemical characteristics in terms of water uptake percentage, cation exchange capacity, proton conductivity (σ), and methanol permeability. MS dispersion in the copolymer matrix is proved through morphological SEM examination. The S-PPMS membranes exhibit increased proton conductivity due to the presence of well-dispersed MS and surface functional –SO3H groups. A peak power density of 210 mWcm?2 is recorded for S-PPMS10 at 110 °C, which is higher than the output obtained from Nafion-117. These promising results indicate the potential utilization of prepared nanocomposite PEMs for DMFC application. 相似文献