Analytical techniques for determining biotin

Biotin is a vitamin of the B-complex, which plays an important biochemical role in every living cell. In the recent years, the interest in this vitamin has been rekindled, mainly due to its association with serious human disorders, such as the inherited syndrome multiple carboxylase deficiency, which can be successfully treated with biotin administration. Diagnosis of biotin deficiency as well as monitoring of biotin levels in biological fluids of patients receiving biotin treatment is crucial. Equally important is the determination of biotin levels in pharmaceutical preparations as well as in food and food supplement products, which constitute the main source of biotin in humans. Several analytical methods for measuring biotin in various samples, e.g. human fluids, pharmaceutical formulations, food material etc., have been reported in the literature. In this review, the most representative of these methods are presented, and their characteristics are evaluated.     

Modelling Operational Risk Losses with Graphical Models and Copula Functions

The management of Operational Risk has been a difficult task due to the lack of data and the high number of variables. In this project, we treat operational risks as multivariate variables. In order to model them, copula functions are employed, which are a widely used tool in finance and engineering for building flexible joint distributions. The purpose of this research is to propose a new methodology for modelling Operational Risks and estimating the required capital. It combines the use of graphical models and the use of copula functions along with hyper-Markov law. Historical loss data of an Italian bank is used, in order to explore the methodology’s behaviour and its potential benefits.      

New multi-electron high capacity anodes based on nanoparticle vanadium phosphides

Nanoscale vanadium phosphides can serve as new high capacity anodes in alkaline aqueous electrolytes. Competing corrosion reaction(s) are mitigated with the novel use of an anion exchange membrane providing for capacities as high as 2800 mAh g(-1) @ 100 mA g(-1) discharge rate.     

Monitoring Methylmalonic Aciduria by NMR Urinomics

The paper reports on monitoring methylmalonic aciduria (MMA)-specific and non-specific metabolites via NMR urinomics. Five patients have been monitored over periods of time; things involved were diet, medication and occasional episodes of failing to comply with prescribed diets. An extended dataset of targeted metabolites is presented, and correlations with the type of MMA are underlined. A survey of previous NMR studies on MMA is also presented.     

Monitoring of Polycyclic Aromatic Hydrocarbon Levels in Mussels (Mytilus galloprovincialis) from Aquaculture Farms in Central Macedonia Region,Greece, Using Gas Chromatography–Tandem Mass Spectrometry Method

A new sensitive and selective gas chromatography tandem mass spectrometry (GC-MS/MS) method was developed for the analysis of 26 polycyclic aromatic hydrocarbons (PAHs), including 16 Environmental Protection Agency (EPA) and 15 + 1 European Union (EU) PAHs, in mussel samples from aquaculture farms in Thermaikos and Strymonian Gulf, Central Macedonia Region, in three sampling periods. Concentrations were found at moderate to low values at all sampling sites, without exceeding maximum levels set by EU. Low molecular weight PAHs were predominant in all samples. Seasonal variation of the concentrations was observed; values were slightly higher in the winter period. Use of diagnostic ratios for potential sources of PAHs showed both petrogenic and pyrolitic origin. In comparison to other related studies of mussels from the Mediterranean Sea, Greek mussels cultivated in the studied gulfs are low in contaminants due to minimal environmental pollution effects. Low concentrations of PAHs are in compliance with the low values of other POPs which were found in the mussels.     

Selection among ranked projects under segmentation,policy and logical constraints

The paper proposes a method for project selection under a specific decision situation, where a final selection is guided by two aspects: (1) satisfaction of certain segmentation, policy and/or logical constraints, and (2) assurance that the individual evaluation of the projects is respected to the maximum degree. This approach is somewhat different than the usual portfolio optimization, where combinations of projects are compared without special concern on respecting the project’s ranking. The entire process is implemented in two phases: the projects are first ranked, usually through a multicriteria approach. The obtained complete preorder of the projects is then used in an integer programming module in order to effectively drive the final selection that satisfies the segmentation and/or logical constraints. The innovative part of the proposed approach is the way it overcomes the well-known bias towards low cost projects which is caused by the knapsack formulation commonly used in the integer programming phase. Actually this is the main source of divergence between the final selection and the initial complete preorder of the projects. The proposed method improves an agreement between the final selection of projects obtained from the integer programming model and the ranking obtained from the multicriteria approach.     

Graphene-Ni-α-MnO2 and -Cu-α-MnO2 nanowire blends as highly active non-precious metal catalysts for the oxygen reduction reaction

Graphene-like carbon-Ni-α-MnO(2) and -Cu-α-MnO(2) blends can serve as effective catalysts for the oxygen reduction reaction with activities comparable to Pt/C.     

Interaction behavior in ultrafiltration of nonionic surfactant micelles by adsorption

Adsorption of nonionic surfactant micelles onto ultrafiltration (UF), membranes was studied. Two homologous series of nonionic surfactants, namely, Tritons (alkylphenol ethoxylates) and Neodols (alcohol ethoxylates), were used to characterize surface properties of two polymeric ultrafiltration membranes with 20,000 nominal cutoff. Particularly, a cellulose acetate and a polysulfone membrane were investigated. Static adsorption experiments were carried out using surfactant solutions at concentrations above their critical micelle concentration. The characterization of surface properties of UF membranes was based on the adsorption behavior of surfactant species. The adsorption extent on UF membranes was affected by the hydrophobicity-to-hydrophilicity ratio mainly determining the interactions developed at the membrane-surfactant species interface. Adsorption experimental data seem generally to fit the Langmuir isotherm model. Atomic force microscopy was used to examine the alteration of the top membrane surface morphology.