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Chate Asha V. Dongre Ravindra M. Khaire Mahadeo K. Bondle Giribala M. Sangshetti Jaiprakash N. Damale Manoj 《Research on Chemical Intermediates》2018,44(10):6119-6136
Research on Chemical Intermediates - Simple and green synthetic procedures constitute an important goal in organic synthesis. The combination of multicomponent reactions (MCRs) and unconventional... 相似文献
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Amol A. Nagargoje Satish V. Akolkar Madiha M. Siddiqui Aditi V. Bagade Kisan M. Kodam Jaiprakash N. Sangshetti Manoj G. Damale Bapurao B. Shingate 《中国化学会会志》2019,66(12):1658-1665
A series of pyrazole‐incorporated monocarbonyl analogues of curcumin were synthesized via Clasien–Schimidt‐type condensation and subsequently screened for in vitro antiproliferative and antioxidant activity. The analogues 4c, 5d, 5e, 5g, 6e, and 6f showed potential activity against the MDA‐MB‐231 cell line. The synthesized analogues were also screened for their antioxidant activity. Compounds 5a , 5e , 6d, and 6f exhibit comparable radical scavenging activity with respect to the standard drug ascorbic acid. Furthermore, a molecular docking study has been conducted for 5d and 5g and suggests that these compounds have a potential to become lead molecules in drug discovery and process. 相似文献
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