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Jia-Hua Cui Dagula Hu Xu Zhang Zheng Jing Jing Ding Ru-Bing Wang Shao-Shun Li 《中国化学快报》2013,24(3):215-218
The flavonoids as inhibitors of CYP1Al exhibit chemopreventive effects against certain procarcinogens and have been considered as the promising cancer preventive agents.A series of novel 7,8-dimethoxy-αnaphthoflavones as the substrate analogs were designed and prepared.The enzyme assay suggested that all of these new flavones were stronger inhibitors of CYP1 Al than the lead compoundα-naphthoflavone. Among the tested ones,3h showed the most potent inhibitory effects. 相似文献
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