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1.
Anthony Linden Cihat afak Emrah Kismetl 《Acta Crystallographica. Section C, Structural Chemistry》2002,58(7):o436-o438
The title compound, C23H29N3O4, has potential calcium modulatory properties. The conformation of the 1,4‐dihydropyridine ring is unusual in that it is planar, instead of the usual shallow boat. The 3‐nitrophenyl substituent is in the synperiplanar orientation with respect to the dihydropyridine ring plane. The oxocyclohexene ring has a distorted envelope conformation, with the out‐of‐plane atom being disordered on opposite sides of the ring plane. The molecules are linked into chains by intermolecular hydrogen bonds. 相似文献
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Hemn A. H. Barzani Hoshyar Saadi Ali Cihat Şahin Musa Kıran Yavuz Yardım 《Electroanalysis》2022,34(8):1280-1288
An effective electrochemical sensor was constructed using an unmodified boron-doped diamond electrode for determination of genistein by square-wave voltammetry. Cyclic voltammetric investigations of genistein with HClO4 solution indicated that irreversible behavior, adsorption-controlled and well-defined two oxidation peaks at about +0.92 (PA1) & +1.27 V (PA2). pH, as well as supporting electrolytes, are important in genistein oxidations. Quantification analyses of genistein were conducted using its two oxidation peaks. Using optimized experiments as well as instrumental conditions, the current response with genistein was proportionately linear in the concentrations range of 0.1 to 50.0 μg mL−1 (3.7×10−7−1.9×10−4 mol L−1), by the detection limit of 0.023 μg mL−1 (8.5×10−8 mol L−1) for PA1 and 0.028 μg mL−1 (1.1×10−7 mol L−1) for PA2 in 0.1 mol L−1 HClO4 solution (in the open circuit condition at 30 s accumulation time). Ultimately, the developed method was effectively applied to detect genistein in model human urine samples by using its second oxidation peak (PA2). 相似文献
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Selami Ercan Ercan Çınar Cihat Özaydın Nuriye Efe Ertürk Reşit Çakmak 《Journal of heterocyclic chemistry》2020,57(7):2875-2888
Designing new inhibitors having less side effects is a need which also could reduce cholesterol levels. To fulfill this aim, we have carried out a molecular docking study toward 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase. A set of designed structural derivatives of statin drugs, eight ligands which are used as HIV-1 integrase inhibitor candidates, a set of terpenoids, and ligands downloaded from Zinc15 database were docked to HMG-CoA reductase enzyme which contains atorvastatin in crystal structure. The analysis of docking studies revealed that statin derivative ligands are more appropriate for inhibition of HMG-CoA reductase. To define the contribution of the molecular properties to the binding of ligands to enzyme structure; the highest occupied molecular orbitals-lowest unoccupied molecular orbitals, hardness, electronegativity, and chemical potential properties of ligands have best score in their sets calculated by quantum mechanical tools. 相似文献
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Anthony Linden Cihat afak Frat Aydn 《Acta Crystallographica. Section C, Structural Chemistry》2004,60(10):o711-o713
The title compound, C20H21ClN2O5, has potential calcium modulatory properties. The 1,4‐dihydropyridine ring has the usual shallow boat conformation. The 2‐chloro‐5‐nitrophenyl ring is oriented such that the chloro substituent is in a synperiplanar orientation with respect to the 1,4‐dihydropyridine ring plane, while the nitro substituent sits over the 1,4‐dihydropyridine ring. The cyclohexenone ring has a conformation that is approximately half‐way between that of an envelope and that of a half‐chair. The molecules are linked into chains by intermolecular N—H⋯O hydrogen bonds. 相似文献
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Rahime imek Anthony Linden Cihat afak 《Acta Crystallographica. Section C, Structural Chemistry》2000,56(3):351-353
The title compound, C19H18BrNO3, has potential calcium modulatory properties. The 1,4‐dihydropyridine ring has a very shallow boat conformation and is one of the most planar examples of this moiety. The 2‐bromophenyl substituent is in the axial synperiplanar orientation. The quinoline ring has a half‐chair conformation, with the unusual arrangement of the out‐of‐plane atom being on the opposite side of the ring plane to the bromophenyl substituent. The molecules are linked into chains by intermolecular hydrogen bonds. 相似文献
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Anthony Linden Miyase G. Gündüz Rahime imek Cihat afak 《Acta Crystallographica. Section C, Structural Chemistry》2006,62(4):o227-o230
A mixture of the RR/SS and RS/SR diastereoisomeric pairs of methyl 4‐(2,4‐dichlorophenyl)‐2,7‐dimethyl‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate, C19H19Cl2NO3, forms cocrystals in which there is one unique molecule in the asymmetric unit, but the molecule displays disorder in the region of the 7‐position of the quinoline ring system as a result of the random occurrence of the diastereoisomers at the same crystallographic site. A similar arrangement exists in the monohydrate cocrystals that form from a mixture of the RR/SS and RS/SR diastereoisomeric pairs of methyl 4‐(2,4‐dichlorophenyl)‐2‐methyl‐7‐phenyl‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxylate monohydrate, C24H21Cl2NO3·H2O. These compounds belong to a class of 1,4‐dihydropyridines whose members have calcium modulatory properties. The 1,4‐dihydropyridine rings have the usual shallow boat conformation. In each structure, the 2,4‐dichlorophenyl ring is oriented such that the 2‐chloro substituent is in a synperiplanar orientation with respect to the 1,4‐dihydropyridine ring plane. In each crystal structure, the molecules are linked into chains by N—H⋯O hydrogen‐bonding interactions. 相似文献
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Cihat Polat 《Computational Statistics》2001,16(1):209-219
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Cihat Arslanturk 《Heat and Mass Transfer》2009,45(4):519-525
Correlation equations for optimum design of annular fins with temperature-dependent thermal conductivity are obtained in the
present work. The nonlinear fin equation which is associated with variable thermal conductivity condition is solved by Adomian
decomposition method that provides an analytical solution in the form of an infinite power series. The optimum radii ratio
of an annular fin which maximizes the heat transfer rate has been found as a function of Biot number and the fin volume for
a given thermal conductivity parameter describing the variation of the thermal conductivity. The fin volume is fixed to obtain
the dimensionless geometrical parameters of the fin with maximum heat transfer rate. The data from the present solutions is
correlated for a suitable range of Biot number and the fin volume. The simple correlation equations presented in this work
can assist for thermal design engineers for optimum design of annular fins with temperature-dependent thermal conductivity. 相似文献