Rearrangement of spiro-benzimidazolines: preparation of N-alkenyl- and N-alkyl-benzimidazol-2-ones

A synthetically useful protocol has been developed for the preparation of highly functionalized N-alkenyl-benzimidazol-2-ones. Reaction of commercially available o-phenylenediamines with variously substituted cyclic ketones provides spiro-benzimidazolines. Treatment of these spiro-benzimidazolines with triphosgene in the presence of potassium carbonate results in rapid rearrangement and formation of N-alkenyl-benzimidazol-2-ones in modest to excellent yield for the two-step sequence. Extension of this methodology toward the preparation of a μ opiate receptor antagonist and droperidol, a potent antiemetic and antipsychotic agent, currently a marketed pharmaceutical is also described. Upon treatment of spiro-benzimidazolines with triphosgene in the presence of sodium triacetoxyborohydride, N-alkyl-benzimidazol-2-ones were formed.     

Indecomposable continua and the Julia sets of polynomials, II

We find necessary and sufficient conditions for the connected Julia set of a polynomial of degree d?2 to be an indecomposable continuum. One necessary and sufficient condition is that the impression of some prime end (external ray) of the unbounded complementary domain of the Julia set J has nonempty interior in J. Another is that every prime end has as its impression the entire Julia set. The latter answers a question posed in 1993 by the second two authors.We show by example that, contrary to the case for a polynomial Julia set, the image of an indecomposable subcontinuum of the Julia set of a rational function need not be indecomposable.     

The hadronic cross section of electron-positron annihilation at 9.5 GeV and the ϒ and ϒ′ resonance parameters

The reaction e⁺e^?→ hadrons has been measured in the ? and ?′ region using the DASP detector at the DESY storage ring DORIS. The following final results are obtained: R_had(9.5 GeV)=3.73±0.16±0.28, Γ_ee(?)=(1.23 ± 0.08 ± 0.12) keV, B_μμ(?)=(3.2±1.3±0.3)%, $\text{Γ}{}_{\mathrm{<mtext>ee</mtext>}}\text{Γ}{}_{\mathrm{<mtext>had</mtext>}}\text{Γ}{}_{\mathrm{<mtext>tot</mtext>}}\text{(?′)=(0.55±0.11 ±0.06)}\text{keV}$, and M(?′)?M(?)=(556 ±10) MeV.     

Cochannel speech separation

The multisignal minimum-cross-entropy spectral analysis (multisignal MCESA) is applied to the problem of separating the speech signals of two talkers speaking simultaneously on a single channel, e.g., when two talkers use a single microphone. A new two-stage approach to the problem is proposed in which a spectral separator is followed by a spectral tailoring procedure. The spectral separator produces an initial estimate of the speech spectrum for each talker. Then the spectral tailoring procedure employs the multisignal MCESA technique to adjust the initial spectral estimates to account for the characteristics of the known cochannel composite speech signal. The research emphasis is placed on the implementation and evaluation of the spectral tailoring procedure, i.e., the use of the multisignal MCESA in the proposed scheme. Its usefulness is evaluated and validated by listening tests and by comparing the spectral distortions of the estimated voices before and after the multisignal MCESA processing.     

The function of Shp2 tyrosine phosphatase in the dispersal of acetylcholine receptor clusters

Background

Tone languages such as Thai and Mandarin Chinese use differences in fundamental frequency (F₀, pitch) to distinguish lexical meaning. Previous behavioral studies have shown that native speakers of a non-tone language have difficulty discriminating among tone contrasts and are sensitive to different F₀ dimensions than speakers of a tone language. The aim of the present ERP study was to investigate the effect of language background and training on the non-attentive processing of lexical tones. EEG was recorded from 12 adult native speakers of Mandarin Chinese, 12 native speakers of American English, and 11 Thai speakers while they were watching a movie and were presented with multiple tokens of low-falling, mid-level and high-rising Thai lexical tones. High-rising or low-falling tokens were presented as deviants among mid-level standard tokens, and vice versa. EEG data and data from a behavioral discrimination task were collected before and after a two-day perceptual categorization training task.

Results

Behavioral discrimination improved after training in both the Chinese and the English groups. Low-falling tone deviants versus standards elicited a mismatch negativity (MMN) in all language groups. Before, but not after training, the English speakers showed a larger MMN compared to the Chinese, even though English speakers performed worst in the behavioral tasks. The MMN was followed by a late negativity, which became smaller with improved discrimination. The High-rising deviants versus standards elicited a late negativity, which was left-lateralized only in the English and Chinese groups.

Conclusion

Results showed that native speakers of English, Chinese and Thai recruited largely similar mechanisms when non-attentively processing Thai lexical tones. However, native Thai speakers differed from the Chinese and English speakers with respect to the processing of late F₀ contour differences (high-rising versus mid-level tones). In addition, native speakers of a non-tone language (English) were initially more sensitive to F₀ onset differences (low-falling versus mid-level contrast), which was suppressed as a result of training. This result converges with results from previous behavioral studies and supports the view that attentive as well as non-attentive processing of F₀ contrasts is affected by language background, but is malleable even in adult learners.     

Secondary ion yields produced by keV atomic and polyatomic ion impacts on a self-assembled monolayer surface

A suite of keV polyatomic or 'cluster' projectiles was used to bombard unoxidized and oxidized self-assembled monolayer surfaces. Negative secondary ion yields, collected at the limit of single ion impacts, were measured and compared for both molecular and fragment ions. In contrast to targets that are orders of magnitude thicker than the penetration range of the primary ions, secondary ion yields from polyatomic projectile impacts on self-assembled monolayers show little to no enhancement when compared with monatomic projectiles at the same velocity. This unusual trend is most likely due to the structural arrangement and bonding characteristics of the monolayer molecules with the Au(111). Copyright 1999 John Wiley & Sons, Ltd.