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On treatment of the 2-allyl-3-aminocyclohexenones with mercury(II) acetate, either sequence, dehydrogenation—oxymercuration or dehydrogenation—aminomercuration, occurred depending on the nature of the amino group in the substrate to yield the dihydrobenzofurans or indoles, respectively. 相似文献
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An enantioselective total synthesis of (-)-lepadin B has been developed starting from (2S,4S)-2,4-O-benzylidene-2, 4-dihydroxybutanal. The key steps in the synthesis include the use of an aqueous intramolecular acylnitroso Diels-Alder reaction to afford the trans-1,2-oxazinolactam and Suzuki cross-coupling reaction to elaborate the (E,E)-octadienyl unit. 相似文献
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[reaction: see text] The enantioselective total syntheses of (+)-azimine and (+)-carpaine have been developed, starting with (S)-1,2,4-butanetriol as a single source of chirality. The key common feature in these syntheses involves stereoselective intramolecular hetero-Diels-Alder reaction of an acylnitroso compound. The critical macrocyclic dilactonization of the N-Cbz derivatives of azimic acid and carpamic acid was efficiently achieved by using the Yamguchi macrocyclization conditions. 相似文献
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Dutta S Abe H Aoyagi S Kibayashi C Gates KS 《Journal of the American Chemical Society》2005,127(43):15004-15005
Fasicularin is a structurally novel thiocyanate-containing alkaloid isolated from the ascidian Nephteis fasicularis. Early biological experiments suggested that this compound's cytotoxic properties may stem from its ability to damage cellular DNA. Sequence gel analysis reveals that treatment of a 5'-32P-labeled DNA duplex with fasicularin in pH 7.0 buffer causes strand cleavage selectively at guanine residues. Further experiments indicate that production of these base-labile lesions in DNA involves alkylation of guanine residues by a fasicularin-derived aziridinium ion. This work reveals fasicularin as the first natural product found to generate a DNA-alkylating aziridinium ion via a mechanism analogous to the clinically used anticancer drugs mechlorethamine, melphalan, and chlorambucil. 相似文献
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Kibayashi C 《Chemical & pharmaceutical bulletin》2005,53(11):1375-1386
A group of naturally occurring substances containing nitrogen is widely distributed in plants as well as in fungi, animal, marine organisms, and insects, and many exhibit significant biological activity. These natural products with a huge variety of chemical structures include antibiotics, antitumor agents, immunostimulants, drugs affecting the cardiovascular and central nervous systems, analgesics etc. The diverse activities and low natural abundance of this group of natural products when coupled with their molecular complexity warrant development of new and efficient synthetic methods and strategy for the total synthesis of these products, in particular alkaloids. The purpose of this review is to describe some of our achievements in the total synthesis of the naturally-occurring bases including the Dendrobatid alkaloids pumiliotoxin B and allopumiliotoxin A, the anitibiotic streptazolin, the tricyclic marine alkaloids isolated from the ascidians such as fasicularin, lepadiformine, and cylindricine C, and the dimeric monoterpene alkaloid incarvillateine as well as the formal total synthesis of the spirocyclic marine alkaloids halichlorine and pinnaic acid, which are isolated from the Japanese marine sponge and the Okinawan bivalve, respectively. 相似文献
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Stereospecific reversible deactivation radical polymerization of biomass‐based acrylates for precise control of tacticity and molecular weight 下载免费PDF全文
Hitoshi Tanaka Tatsuya Kibayashi Kazuya Okuda Shoichi Kashihara 《Journal of polymer science. Part A, Polymer chemistry》2017,55(3):445-456
Reversible deactivation radical polymerization (RDRP) of biomass‐based acrylates, (S )‐ and (R )‐2‐isopropyl‐5‐methylene‐1,3‐dioxolan‐4‐ones (S‐MiPDO and R‐MiPDO), was successfully performed to produce a well‐defined polymer with simultaneously controlled tacticity and molecular weight, and low dispersity (? < 1.3). In particular, meso triad (mm ) of the polymer was continuously controlled as designed from 28.1% to about 100% by changing the molar ratio of S‐MiPDO/R‐MiPDO in feed. In kinetic studies, the rate of RDRP was strongly influenced by the stereostructures of the propagating radical, and it was much lower in isospecific RDRP than atactic one in reversible chain transfer catalyzed polymerization (RTCP) in contrast to atom transfer radical polymerization (ATRP) where the rate would not change regardless of the tacticity. Increase of molecular weight and low ? of the polymer were also observed in reversible addition‐fragmentation chain transfer (RAFT) polymerization of MiPDO. In addition, block copolymers including stereoblock copolymers were feasibly synthesized by RTCP of styrene and methyl methacrylate using poly(MiPDO) prepolymer. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017 , 55 , 445–456 相似文献
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[reaction: see text] The tricyclic N-acyl-N,O-acetal incorporating (S)-2-(1-aminoethyl)phenol as a chiral auxiliary underwent TiCl4-mediated allylation to give the chiral (5S)-allylpyrrolidinone with retention of configuration in high yield and diastereoselectivity. On the bases of this methodology, the asymmetric syntheses of the dendrobatid alkaloids (-)-indolizidines 167B and 209D were achieved. 相似文献
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Malek M Morii M Fukuda S Fukuda Y Ishitsuka M Itow Y Kajita T Kameda J Kaneyuki K Kobayashi K Koshio Y Miura M Moriyama S Nakahata M Nakayama S Namba T Okada A Ooyabu T Saji C Sakurai N Shiozawa M Suzuki Y Takeuchi H Takeuchi Y Totsuka Y Yamada S Desai S Earl M Kearns E Messier MD Stone JL Sulak LR Walter CW Goldhaber M Barszczak T Casper D Gajewski W Kropp WR Mine S Liu DW Smy MB Sobel HW Vagins MR Gago A Ganezer KS Keig WE Ellsworth RW Tasaka S Kibayashi A Learned JG Matsuno S Takemori D 《Physical review letters》2003,90(6):061101
A search for the relic neutrinos from all past core-collapse supernovae was conducted using 1496 days of data from the Super-Kamiokande detector. This analysis looked for electron-type antineutrinos that had produced a positron with an energy greater than 18 MeV. In the absence of a signal, 90% C.L. upper limits on the total flux were set for several theoretical models; these limits ranged from 20 to 130 macro nu(e) cm(-2) s(-1). Additionally, an upper bound of 1.2 macro nu(e) cm(-2) s(-1) was set for the supernova relic neutrino flux in the energy region E(nu)>19.3 MeV. 相似文献