Global Analysis of the Flows of Fluids with Pressure-Dependent Viscosities

 To describe the flows of fluids over a wide range of pressures, it is necessary to take into account the fact that the viscosity of the fluid depends on the pressure. That the viscosity depends on the pressure has been verified by numerous careful experiments. While the existence of solutions local-in-time to the equations governing the flows of such fluids are available for small, special data and rather unrealistic dependence of the viscosity on the pressure, no global existence results are in place. Our interest here is to establish the existence of weak solutions for spatially periodic three-dimensional flows that are global in time, for a large class of physically meaningful viscosity-pressure relationships. (Accepted May 1, 2002) Published online November 15, 2002 Communicated by S. S. ANTMAN     

Population kinetics in turbulent plasmas: The role of non-Markovian fluctuations

A novel approach to the modeling of atomic populations in turbulent plasmas is applied to ionization-recombination balance calculations. Fluctuations of the fluid parameters are retained using a time-dependent statistical approach, suitable for cases where the turbulence characteristic times are of the same order as or smaller than the typical atomic relaxation times. We show that the populations are sensitive to the shape of the autocorrelation function of the fluctuations. An illustration is proposed through an ideal two-level system forced by non-Markovian temperature fluctuations.     

A spectroscopic investigation of turbulence in magnetized plasmas

We present a spectroscopic investigation of turbulence in the Tore-Supra edge plasma, where deuterium spectral lines are found to exhibit a power-law behavior in their wings. Such a feature is not predicted by the equilibrium line broadening theory in the conditions of the edge plasma, where the thermal Stark effect is negligible. Therefore, the possible role of turbulence is investigated along two separate paths. Indeed, both the Stark and the Doppler profiles may differ significantly from the equilibrium profiles.     

Guided modes of integrated optical guides. A mathematical study

A waveguide in integrated optics is defined by its refractiveindex. The guide is assumed to be invariant in the propagationdirection while in the transverse direction it is supposed tobe a compact perturbation of an unbounded stratified medium.We are interested in the modes guided by this device, whichare waves with a transverse energy confined in a neighbourhoodof the perturbation. Our goal is to analyse the existence of such guided modes. Underthe assumptions of weak guidance the problem reduces to a two-dimensionaleigenvalue problem for a scalar field. The associated operatoris unbounded, selfadjoint, and bounded from below. Its spectrumconsists of the discrete spectrum corresponding to the guidedmodes and of the essential spectrum corresponding to the radiationmodes. We present existence results of guided modes and an asymptoticstudy at high frequencies, which shows that contrarily to thecase of optical fibers, the number of guided modes can remainbounded. The major tools are the min-max principle and comparisonof results between different eigenvalue problems. The originalityof the present study lies in the stratified character of theunbounded reference medium.     

Spectral line shapes modeling in turbulent plasmas

In this work we investigate the influence of low frequency turbulence on Doppler spectral line shapes in magnetized plasmas. Low frequency refers here to fluctuations whose typical time scale is much larger than those characterizing the atomic processes, such as radiative decay, collisions and charge exchange. This ordering is in particular relevant for drift wave turbulence, ubiquitous in edge plasmas of fusion devices. Turbulent fluctuations are found to affect line shapes through both the spatial and time averages introduced by the measurement process. The profile is expressed in terms of the fluid fields describing the plasma. Assuming the spectrometer acquisition time to be much larger than the turbulent time scale, an ordering generally fulfilled in experiments, allows to develop a statistical formalism. We proceed by successively investigating the effects of density, fluid velocity and temperature fluctuations on the Doppler profile of a spectral line emitted by a charge exchange population of neutrals. Line shapes, and especially line wings are found to be affected by ion temperature or fluid velocity fluctuations, and can in some cases exhibit a power-law behavior. These effects are shown to be measurable with existing techniques, and their interpretation in each particular case would rely on already existing tools. From a fundamental point of view, this study gives some insights in the appearance of non-Boltzmann statistics, such as Lévy statistics, when dealing with averaged experimental data.     

Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence

Background  

Opioid agonist drugs produce analgesia. However, long-term exposure to opioid agonists may lead to opioid dependence. The analgesic and addictive properties of opioid agonist drugs are mediated primarily via the mu-opioid receptor (MOR). Opioid agonists appear to alter neuronal morphology in key brain regions implicated in the development of opioid dependence. However, the precise role of the MOR in the development of these neuronal alterations remains elusive. We hypothesize that identifying and characterizing novel MOR interacting proteins (MORIPs) may help to elucidate the underlying mechanisms involved in the development of opioid dependence.     

Highly diastereoselective synthesis of vicinal quaternary and tertiary stereocenters using the iodo-aldol cyclization

The intramolecular iodo-aldol cyclization of alpha-substituted enoate aldehydes and ketones is described. Using prochiral starting materials, the reaction produces hetero- and carbocycles containing quaternary centers adjacent to secondary or tertiary centers. The reactions occur in good yields and are highly selective for the trans-products, having the hydroxyl and iodomethyl groups on opposite faces of the ring system.     

High precision delta(17)O isotope measurements of oxygen from silicates and other oxides: method and applications

The use of infrared laser-assisted fluorination to release oxygen from milligram quantities of silicates or other oxide mineral grains is a well-established technique. However, relatively few studies have reported the optimisation of this procedure for oxygen-17 isotope measurements. We describe here details of an analytical system using infrared (10 μm) laser-assisted fluorination, in conjunction with a dual inlet mass spectrometer of high resolving power ( approximately 250) to provide (17)O and (18)O oxygen isotope measurements from 0.5-2 mg of silicates or other oxide mineral grains. Respective precisions (1) of typically 0.08 and 0.04 per thousand are obtained for the complete analytical procedure. Departures from the mass-dependent oxygen isotope fractionation line are quantified by Delta(17)O; our precision (1) of such measurements on individual samples is shown to be +/-0.024 per thousand. In turn, this permits the offset between parallel, mass-dependent fractionation lines to be characterised to substantially greater precision than has been possible hitherto. Application of this system to investigate the (17)O versus (18)O relationship for numerous terrestrial whole-rock and mineral samples, of diverse geological origins and age, indicates that the complete data set may be described by a single, mass-dependent fractionation line of slope 0.5244+/- 0.00038 (standard error). Copyright 1999 John Wiley & Sons, Ltd.