Microwave-assisted synthesis and antifungal activity of some new 1<Emphasis Type="Italic">H</Emphasis>-1,2,4-triazole derivatives

A number of 3-aryl-4-arylmethylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones were synthesized by reaction of the corresponding aromatic aldehydes with 4-amino-3-aryl-1H-1,2,4-triazol-5-ones in anhydrous ethanol under microwave irradiation. The newly synthesized 1H-1,2,4-triazole derivatives were tested for antimicrobial activity. They showed no antibacterial activity but slight mycostatic activity against some Candida species. Published in Russian in Zhurnal Organicheskoi Khimii, 2008, Vol. 44, No. 12, pp. 1843–1847. The text was submitted by the authors in English.     

New 5-methylisatin including thiocarbohydrazones: preparation,structure elucidation and antimicrobial activity

Research on Chemical Intermediates - New 5-methylisatin including thiocarbohydrazones (1–5) have been synthesized. The chemical structure of synthesized compounds was elucidated with IR, 1H...     

Degradation of C<Emphasis Type="Italic">andida albicans</Emphasis> on TiO<Subscript>2</Subscript> and Ag-TiO<Subscript>2</Subscript> thin films prepared by sol–gel and nanosuspensions

In this study, both suspensions and thin films of TiO₂ and silver loaded TiO₂ (Ag-TiO₂) were used in the photocatalytic degradation/disinfection of C. albicans. In the case of thin films coated materials, both microscope slides and steel pieces of similar dimensions were dip coated using sol–gel solutions prepared from titanium isopropoxide. Surface analysis of the materials confirmed that thin film formation had been succesful. After set periods of irradiation in the presence of suspension or thin film coated material, 10 μL aliquots of the solution were withdrawn and directly cultivated on sabouraud dextrose agar for 24 h at 37 °C. The number of living colonies was counted. The results show that both the suspensions and the thin films displayed superior antimicrobial properties towards C. albicans. In particular the Ag-TiO₂ catalyst was extremely active even in the dark, for disinfection of C. albicans. The degradation percentage over TiO₂ and Ag-TiO₂ thin films coated on the steel substrate was higher than those coated on glass achieving 80 and 97.9%, respectively, using the 365 nm, near visible region light source.