Synthesis of new derivatives of α-mangostin (microreview)

Chemistry of Heterocyclic Compounds - This microreview presents the current state of research on functionalization of α-mangostin, a natural hydroxyxanthone. Examples of transformations are...     

Synthesis and evaluation of the antioxidant properties for some novel aminomethyl derivatives of 2,6-diisobornylphenol bearing a pinane moiety

Some new derivatives based on 2,6-diisobornylphenol and containing amine moieties of the pinane structure at the para-position relative to the phenolic hydroxy group were synthesized. The antioxidant properties of the obtained compounds were estimated using various in vitro models. The introduction of diamine moiety into a starting molecule led to a significant increase in the radical scavenging activity and the ability to chelate Fe²⁺ ions.

     

Synthesis oftertiaryamidomethyl derivatives of 2-isobornyl-4-methylphenol

Derivatives containing tertiary amidomethyl groups were prepared by reaction of a secondary aminomethyl derivative of 2-isobornyl-4-methylphenol with succinic and phthalic anhydrides and (1S)-camphanic acid chloride.     

Resolution of racemic 2-isobornyl-4-methylphenol into enantiomers

Resolution of racemic 2-isobornyl-4-methylphenol into enantiomers was performed following its transformation into diastereomers by the reaction with (1S)-camphanoyl chloride.     

Asymmetrically substituted tetra(meso-aryl)porphyrins bearing peripheral 2,6-diisobornylphenol and 2,6-di-tert-butylphenol moieties

Russian Chemical Bulletin - Asymmetrically substituted tetra(meso-aryl)porphyrins bearing peripheral diisobornyl- phenol and di-tert-butylphenol moieties were synthesized by a mixed aldehyde...     

Comparative evaluation of antioxidant activity of 2-alkyl-4-methylphenols and their 6-n-octylaminomethyl derivatives

Russian Chemical Bulletin - A series of 2-alkyl-4-methyl-6-n-octylaminomethylphenols (where alkyl is methyl or tert-butyl group, or terpene substituent) was synthesized. A comparative evaluation of...     

Composition and properties of the reaction products of p-cresol with camphene

Russian Chemical Bulletin - The products of the reaction between p-cresol and camphene were isolated and characterized. Their antiradical activity and toxicity were studied. The pharmacological...     

Design,synthesis and evaluation of the antioxidant and neuroprotective properties of alkyl- and terpenylphenolchlorin conjugates

The new amide conjugates were synthesized from methyl pheophorbide a and its carboxyl derivatives by reactions with aminomethyl derivatives of 2,4-dimethylphenol, 2-isocamphyl-4- methylphenol, 2-bornyl-4-methylphenol, and 2-isobornyl-4-methylphenol. The antioxidant activity of some conjugates was established by investigation of their ability to inhibit the accumulation of secondary products of lipid peroxidation in a brain of laboratory mice in vitro. The neuroprotective properties of porphyrin and terpenylphenol conjugates have been studied on the model of H₂O₂-induced oxidative stress in SH-SY5Y cells (neuroblastoma).