排序方式: 共有35条查询结果,搜索用时 0 毫秒
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Ivanova OA Budynina EM Chagarovskiy AO Trushkov IV Melnikov MY 《The Journal of organic chemistry》2011,76(21):8852-8868
The ability of donor-acceptor cyclopropanes to (3 + 3)-cyclodimerize is disclosed. It has been found that Lewis acid-induced transformations of 2-(hetero)arylcyclopropane-1,1-dicarboxylates containing electron-abundant aromatic substituents led to the construction of six-membered cyclic systems. Depending on the substrate properties and the Lewis acid applied, three types of products can be obtained: (1) 1,4-diarylcyclohexanes, (2) 1-aryl-1,2,3,4-tetrahydronaphthalenes, and (3) 9,10-dihydroanthracenes. 相似文献
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Yuliya A. Volkova Ekaterina M. Budynina Tamara S. Kuznetsova Nikolai S. Zefirov 《Tetrahedron》2008,64(16):3548-3553
A novel approach to acyclic alkyldinitronitronates using nucleophilic opening of epoxides with the trinitromethyl anion is presented. The scope and limitations of this synthetic procedure are presented. A series of highly functionalized 3,3-dinitroisoxazolidines were synthesized as mixtures of diastereomers. 相似文献
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Domino Staudinger/aza‐Wittig/Mannich Reaction: An Approach to Diversity of Di‐ and Tetrahydropyrrole Scaffolds 下载免费PDF全文
Dr. Anna S. Pavlova Dr. Olga A. Ivanova Dr. Alexey O. Chagarovskiy Nikolay S. Stebunov Dr. Nikolay V. Orlov Dr. Alexey N. Shumsky Dr. Ekaterina M. Budynina Dr. Victor B. Rybakov Prof. Dr. Igor V. Trushkov 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(50):17967-17971
A highly efficient and selective domino reaction producing valuable di‐ and tetrahydropyrrole‐based skeletons from azidoethyl‐substituted CH‐acids and (thio)carbonyl compounds has been developed. By involving the additional functional groups in starting compounds into the domino reaction or postmodification of the primary reaction products, the simple construction of the pharmaceutically relevant three‐ and polycyclic azaheterocyclic scaffolds was demonstrated. 相似文献
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Konstantin L. Ivanov Anna A. Kravtsova Elena A. Kirillova Mikhail Ya. Melnikov Ekaterina M. Budynina 《Tetrahedron letters》2019,60(30):1952-1955
A convenient synthetic strategy for the diastereoselective assembly of spiro[azepane-4,3′-oxindoles] was developed via a Staudinger/Michael/aza-Wittig/reduction/N-deprotection reaction sequence starting from PMB-protected oxindole-substituted ethylazides. The key step of the method is a domino self-catalytic Michael/aza-Wittig reaction wherein the phosphazene moiety acts first as the catalyst and then as the reactant, resulting in the formation of a seven-membered N-heterocycle. 相似文献
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M. V. Vishnetskaya O. M. Svichkarev E. M. Budynina M. Ya. Mel’nikov 《Russian Journal of Physical Chemistry A, Focus on Chemistry》2013,87(12):2001-2004
The reaction of methane conversion in anhydrous trifluoroacetic acid (TFA) is shown to take place at room temperature and atmospheric pressure and to result in the formation of a resinous product. Signals of ions with molecular weights of 684 and 700 are observed in MALDI-TOF spectra of the dry residue of methane conversion products. 相似文献
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Ring Opening of Donor–Acceptor Cyclopropanes with the Azide Ion: A Tool for Construction of N‐Heterocycles 下载免费PDF全文
Konstantin L. Ivanov Dr. Elena V. Villemson Dr. Ekaterina M. Budynina Dr. Olga A. Ivanova Dr. Igor V. Trushkov Prof. Mikhail Ya. Melnikov 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(13):4975-4987
A general method for ring opening of various donor–acceptor cyclopropanes with the azide ion through an SN2‐like reaction has been developed. This highly regioselective and stereospecific process proceeds through nucleophilic attack on the more‐substituted C2 atom of a cyclopropane with complete inversion of configuration at this center. Results of DFT calculations support the SN2 mechanism and demonstrate good qualitative correlation between the relative experimental reactivity of cyclopropanes and the calculated energy barriers. The reaction provides a straightforward approach to a variety of polyfunctional azides in up to 91 % yield. The high synthetic utility of these azides and the possibilities of their involvement in diversity‐oriented synthesis were demonstrated by the developed multipath strategy of their transformations into five‐, six‐, and seven‐membered N‐heterocycles, as well as complex annulated compounds, including natural products and medicines such as (?)‐nicotine and atorvastatin. 相似文献