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Dr. Krystle C. H. Chua Dr. Markus Pietsch Xiaozhou Zhang Stephanie Hautmann Hon Y. Chan Dr. John B. Bruning Prof. Dr. Michael Gütschow Prof. Dr. Andrew D. Abell 《Angewandte Chemie (International ed. in English)》2014,53(30):7828-7831
There is a real need for simple structures that define a β‐strand conformation, a secondary structure that is central to peptide–protein interactions. For example, protease substrates and inhibitors almost universally adopt this geometry on active site binding. A planar pyrrole is used to replace two amino acids of a peptide backbone to generate a simple macrocycle that retains the required geometry for active site binding. The resulting β‐strand templates have reduced peptide character and provide potent protease inhibitors with the attachment of an appropriate amino aldehyde to the C‐terminus. Picomolar inhibitors of cathepsin L and S are reported and the mode of binding of one example to the model protease chymotrypsin is defined by X‐ray crystallography. 相似文献
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Simple Zeros of the Riemann Zeta-Function 总被引:1,自引:0,他引:1
Assuming the Riemann Hypothesis, Montgomery showed by meansof his pair correlation method that at least two-thirds of thezeros of Riemann's zeta-function are simple. Later he and Taylorimproved this to 67.25 percent and, more recently, Cheer andGoldston increased the percentage to 67.2753. Here we proveby a new method that if the Riemann and Generalized LindelöofHypotheses hold, then at least 70.3704 percent of the zerosare simple and at least 84.5679 percent are distinct. Our methoduses mean value estimates for various functions defined by Dirichletseries sampled at the zeros of the Riemann zeta-function. 1991Mathematics Subject Classification: 11M26. 相似文献
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This paper concerns a Markov operator T on a space L1, and aMarkov process P which defines a Markov operator on a spaceM of finite signed measures. For T, the paper presents necessaryand sufficient conditions for:
- a the existence of invariant probabilitydensities (IPDs)
- b the existence of strictly positive IPDs,and
- c the existence and uniqueness of IPDs.
- b the existence of strictly positive IPDs,and
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应用新发展的单一轨迹积分方法求解库仑加线性位的基态量子波函数,得到基态能量和波函数的一般解析表达式,并讨论了解的收敛性.应用此方法讨论了重夸克偶素系统. 相似文献
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