排序方式: 共有35条查询结果,搜索用时 46 毫秒
1.
Kristjan S. Gudmundsson Jack M. Hinkley Michael S. Brieger John C. Drach Leroy B. Townsend 《合成通讯》2013,43(5):861-870
An efficient large scale synthesis of 2-amino-4-chloropyridine (3) has been achieved through a modification of existing literature procedures. Compound 3 was used to prepare the previously unreported 2-amino-4,5-dichloropyridine (4). The known 2-amino-3,4-dichloropyridine (5) and 2-amino-3,4,5-trichloropyridine (6) were prepared from 3 by new routes and in higher yields than previously reported. 相似文献
2.
Fr. Schenck M. Einhern P. Guttmann F. Hirschfeld J. Geyer A. Stadthagen und L. Brieger 《Fresenius' Journal of Analytical Chemistry》1890,29(1):378-380
Ohne Zusammenfassung 相似文献
3.
Adolfo Casali Schlagdenhauffen Arm Gautier L. Brieger E. Salkowski und H. Salkowski 《Fresenius' Journal of Analytical Chemistry》1883,22(1):638
Ohne Zusammenfassung 相似文献
4.
Lukas Brieger Christian Unkelbach Prof. Dr. Carsten Strohmann 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(71):17780-17784
The incorporation of heavy alkali metals into substrates is both challenging and essential for many reactions. Here, we report the formation of THF-solvated alkali metal benzyl compounds [PhCH2M ⋅ (thf)n] (M=Na, Rb, Cs). The synthesis was carried out by deprotonation of toluene with the bimetallic mixture n-butyllithium/alkali metal tert-butoxide and selective crystallization from THF of the defined benzyl compounds. Insights into the molecular structure in the solid as well as in solution state are gained by single crystal X-ray experiments and NMR spectroscopic studies. The compounds could be successfully used as alkali metal mediating reagents. The example of caesium showed the convenient use by deprotonating acidic C−H as well as N−H compounds to gain insight into the aminometalation using these reagents. 相似文献
5.
Dr. Lukas Brieger Tobias Schrimpf Rebecca Scheel Dr. Christian Unkelbach Prof. Dr. Carsten Strohmann 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(69):e202202660
The metalation of N,N-dimethylaminomethylferrocene in THF by the superbasic mixture of nBuLi/KOtBu proceeds readily at low temperatures to afford a bimetallic Li2K2 aggregate containing ferrocenyl anions and tert-butoxide. Starting from an enantiomerically enriched ortho-lithiated aminomethylferrocene, an enantiomerically pure superbase can be prepared. The molecular compound exhibits superbasic behavior deprotonating N,N-dimethylbenzylamine in the α-position and is also capable of deprotonating toluene. Quantum chemical calculations provide insight into the role of the bridging THF molecule to the possible substrate–reagent interaction. In addition, a benzylpotassium alkoxide adduct gives a closer look into the corresponding reaction site of the Lochmann–Schlosser base that is reported herein. 相似文献
6.
We continue our investigation of stochastic lattice gases as a (highly parallel) means of simulating given PDEs, in this case Burgers' equation in one dimension. The lattice dynamics consists of stochastic unidirectional particle displacement, and our attention is turned toward the reliability of the model, i.e., its ability to reproduce the unique physical solution of Burgers' equation. Lattice gas results are discussed and compared against finite-difference calculations and exact solutions in examples which include shocks and rarefaction waves. 相似文献
7.
A. Gabriel Pouchet L. Brieger Z. Marino-Zucco A. Poehl W. Tobien R. von Stern Giacomelli H. Maas Arm Gautier und A. Etard 《Fresenius' Journal of Analytical Chemistry》1884,23(1):450-452
Ohne Zusammenfassung 相似文献
8.
9.
Norel L Pointillart F Train C Chamoreau LM Boubekeur K Journaux Y Brieger A Brook DJ 《Inorganic chemistry》2008,47(7):2396-2403
The 3-(2'-imidazolyl)-1,5-dimethyl-6-oxoverdazyl radical (imvd(*)) and the corresponding tetrazane H3imvd were prepared and structurally characterized, the former as two different hydrates. Reaction of imvd(*) with [M(hfac)2] led to the formation of monometallic complexes [M(hfac)2(imvd(*))] (M = Ni and Mn). They were characterized by single-crystal X-ray diffraction. In the solid state, all four radical-containing compounds exhibit imidazole-oxoverdazyl pi stacking. Following the structural analysis, imvd(*) behaves as an antiferromagnetic (AF) coupled chain with J = -100 cm(-1) (H = -J summation operator SiS(i+1)). The magnetic behavior of [M(hfac)2(imvd(*))] complexes is interpreted with a four-coupled spin model with a metal ion radical intramolecular interaction (JMn = -62.5 cm(-1) and JNi = 193 cm(-1); H = -JSMSimvd) and an AF intermolecular interaction (JMn' = -12.6 cm(-1) and JNi' = -4.3 cm(-1)) related to imidazole-oxoverdazyl pi stacking. 相似文献
10.
Nourhne Chouchne Amani Toumi Sarra Boudriga Hayet Edziri Mansour Sobeh Mohamed A. O. Abdelfattah Moheddine Askri Michael Knorr Carsten Strohmann Lukas Brieger Armand Soldera 《Molecules (Basel, Switzerland)》2022,27(3)
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical calculations studies, using the DFT approach, were performed to rationalize the stereochemical outcome. These N-heterocycles were evaluated for their antibacterial and antifungal activities against some pathogenic organisms. Several compounds displayed moderate to excellent activity towards the screened microbe strains in the study compared to Amoxicillin (AMX), Ampicillin (AMP), and Amphotericin B. Furthermore, a structural activity relationship (SAR) was established considering the synthesized compounds. Pharmacokinetic studies reveal that these derivatives exhibit an acceptable predictive ADMET profile (Absorption, Distribution, Metabolism, Excretion and Toxicity) and good drug-likeness. 相似文献