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1.
Briana L. Simms Nan Ji Indika Chandrasiri Mohammad Farid Zia Chinwe S. Udemgba Ravinder Kaur Jared H. Delcamp Alex Flynt Chalet Tan Davita L. Watkins 《Journal of polymer science. Part A, Polymer chemistry》2021,59(19):2177-2192
Here, we demonstrate the applicability of self-assembling linear-dendritic block copolymers (LDBCs) and their nanoaggregates possessing varied surfaces as therapeutic nanocarriers. These LDBCs are comprised of a hydrophobic, linear polyester chemically coupled to a hydrophilic dendron polyamidoamine (PAMAM)—the latter of which acts as the surface of the self-assembled nanoaggregate in aqueous media. To better understand how surface charge density affects the overall operability of these nanomaterials, we modified the nanoaggregate surface to yield cationic (NH3+), neutral (OH), and anionic (COO−) surfaces. The effect of these modifications on the physicochemical properties (i.e., size, morphology, and surface charge density), colloidal stability, and cellular uptake mechanism of the polymeric nanocarrier were investigated. This comparative study demonstrates the viability of nanoaggregates formed from PDLLA-PAMAM LDBCs to serve as nanocarriers for applications in drug delivery. 相似文献
2.
Shestopalov AA Morris CJ Vogen BN Hoertz A Clark RL Toone EJ 《Langmuir : the ACS journal of surfaces and colloids》2011,27(10):6478-6485
We report a simple, reliable high-throughput method for patterning passivated silicon with reactive organic monolayers and demonstrate selective functionalization of the patterned substrates with both small molecules and proteins. The approach completely protects silicon from chemical oxidation, provides precise control over the shape and size of the patterned features in the 100 nm domain, and gives rapid, ready access to chemically discriminated patterns that can be further functionalized with both organic and biological molecules. 相似文献
3.
Renteln proved that the eigenvalues of the distance matrix of a Cayley graph of a real reflection group with respect to the set of all reflections are integral and provided a combinatorial formula for some such spectra. We prove the eigenvalues of the distance, adjacency, and codimension matrices of Cayley graphs of complex reflection groups with connection sets consisting of all reflections are integral and provide a combinatorial formula for the codimension spectra for a family of monomial complex reflection groups. 相似文献
4.
Snyder PW Johannes MS Vogen BN Clark RL Toone EJ 《The Journal of organic chemistry》2007,72(19):7459-7461
Immobilized biocatalytic lithography is presented as an application of soft lithography. In traditional microcontact printing, diffusion limits resolution of pattern transfer. By using an immobilized catalyst, the lateral resolution of microcontact printing would depend only on the length and flexibility of the tether (<2 nm) as opposed to diffusion (>100 nm). In the work, exonuclease reversibly immobilized on a relief-patterned stamp is used to ablate ssDNA monolayers Percent of ablation was determined via confocal fluorescence microscopy to be approximately 70%. 相似文献
5.
Cindy B. McReynolds Jun Yang Alonso Guedes Christophe Morisseau Roberto Garcia Heather Knych Caitlin Tearney Briana Hamamoto Sung Hee Hwang Karen Wagner Bruce D. Hammock 《Molecules (Basel, Switzerland)》2021,26(16)
There are few novel therapeutic options available for companion animals, and medications rely heavily on repurposed drugs developed for other species. Considering the diversity of species and breeds in companion animal medicine, comprehensive PK exposures in the companion animal patient is often lacking. The purpose of this paper was to assess the pharmacokinetics after oral and intravenous dosing in domesticated animal species (dogs, cats, and horses) of a novel soluble epoxide hydrolase inhibitor, EC1728, being developed for the treatment of pain in animals. Results: Intravenous and oral administration revealed that bioavailability was similar for dogs, and horses (42 and 50% F) but lower in mice and cats (34 and 8%, respectively). Additionally, clearance was similar between cats and mice, but >2× faster in cats vs. dogs and horses. Efficacy with EC1728 has been demonstrated in mice, dogs, and horses, and despite the rapid clearance of EC1728 in cats, analgesic efficacy was demonstrated in an acute pain model after intravenous but not oral dosing. Conclusion: These results demonstrate that exposures across species can vary, and investigation of therapeutic exposures in target species is needed to provide adequate care that addresses efficacy and avoids toxicity. 相似文献
6.
Adam D. Gill Lizeth Perez Isaac N. Q. Salinas Samantha R. Byers Yang Liu Briana L. Hickey Prof. Wenwan Zhong Prof. Richard J. Hooley 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(7):1740-1745
Arrayed complexes of a water-soluble deep cavitand and two fluorescent indicators show selective sensing of anabolic-androgenic steroids in aqueous environments. By combining the host–guest complexes with small amounts of heavy metal ions, discrimination between steroids that vary in structure by only a single π bond is possible. The sensing occurs through a triggered aggregation mechanism, which can be mediated by both the presence of metal ions and the steroids. The use of both “turn-on” and “turn-off” fluorophores is essential for good discrimination. As low as 10 μm steroid can be detected, and the discrimination is selective in steroid samples spiked into human urine. 相似文献
7.
Patrick Fadden Kenneth H. Huang James M. Veal Paul M. Steed Amy F. Barabasz Briana Foley Mei Hu Jeffrey M. Partridge John Rice Anisa Scott Laura G. Dubois Tiffany A. Freed Melanie A. Rehder Silinski Thomas E. Barta Philip F. Hughes Andy Ommen Wei Ma Emilie D. Smith Angela Woodward Spangenberg Jeron Eaves Steven E. Hall 《Chemistry & biology》2010,17(7):686-694
8.
Lower Activation Energy for Catalytic Reactions through Host–Guest Cooperation within Metal–Organic Frameworks 下载免费PDF全文
Briana Aguila Dr. Qi Sun Xiaoliang Wang Erica O'Rourke Prof. Abdullah M. Al‐Enizi Prof. Ayman Nafady Prof. Shengqian Ma 《Angewandte Chemie (International ed. in English)》2018,57(32):10107-10111
Industrial synthesis is driven by a delicate balance of the value of the product against the cost of production. Catalysts are often employed to ensure product turnover is economically favorable by ensuring energy use is minimized. One method, which is gaining attention, involves cooperative catalytic systems. By inserting a flexible polymer into a metal–organic framework (MOF) host, the advantages of both components work synergistically to create a composite that efficiently fixes carbon dioxide to transform various epoxides into cyclic carbonates. The resulting material retains high yields under mild conditions with full reusability. By quantitatively studying the kinetic rates, the activation energy was calculated, for a physical mixture of the catalyst components to be about 50 % higher than that of the composite. Through the unification of two catalytically active components, a new opportunity opens up for the development of synergistic systems in multiple applications. 相似文献
9.
Briana Foster-Greenwood 《代数通讯》2013,41(10):4350-4365
Reflection length and codimension of fixed point spaces induce partial orders on a complex reflection group. Motivated by connections to the algebraic structure of cohomology governing deformations of skew group algebras, we show that Coxeter groups and the infinite family G(m, 1, n) are the only irreducible complex reflection groups for which reflection length and codimension coincide. We then discuss implications for the degrees of generators of Hochschild cohomology. Along the way, we describe the codimension atoms for the infinite family G(m, p, n), give algorithms using character theory, and determine two-variable Poincaré polynomials recording reflection length and codimension. 相似文献
10.
Evans BA Fiser BL Prins WJ Rapp DJ Shields AR Glass DR Superfine R 《Journal of magnetism and magnetic materials》2012,324(4):501-507
Magnetic elastomers have been widely pursued for sensing and actuation applications. Silicone-based magnetic elastomers have a number of advantages over other materials such as hydrogels, but aggregation of magnetic nanoparticles within silicones is difficult to prevent. Aggregation inherently limits the minimum size of fabricated structures and leads to non-uniform response from structure to structure. We have developed a novel material that is a complex of a silicone polymer (polydimethylsiloxane-co-aminopropylmethylsiloxane) adsorbed onto the surface of magnetite (γ-Fe2O3) nanoparticles 7-10 nm in diameter. The material is homogenous at very small length scales (<100 nm) and can be crosslinked to form a flexible magnetic material, which is ideally suited for the fabrication of micro- to nanoscale magnetic actuators. The loading fraction of magnetic nanoparticles in the composite can be varied smoothly from 0 to 50 wt% without loss of homogeneity, providing a simple mechanism for tuning actuator response. We evaluate the material properties of the composite across a range of nanoparticle loading, and demonstrate a magnetic-field-induced increase in compressive modulus as high as 300%. Furthermore, we implement a strategy for predicting the optimal nanoparticle loading for magnetic actuation applications, and show that our predictions correlate well with experimental findings. 相似文献