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1.
KL Britton HF Rogers Y Asano T Dairi Y Kato TJ Stillman DW Rice 《Acta crystallographica. Section D, Biological crystallography》1998,53(4):124-126
The novel NAD+-linked opine dehydrogenase from a soil isolate Arthrobacter sp. strain 1C belongs to an enzyme superfamily whose members exhibit quite diverse substrate specificites. Crystals of this opine dehydrogenase, obtained in the presence or absence of co-factor and substrates, have been shown to diffract to beyond 1.8 ? resolution. X-ray precession photographs have established that the crystals belong to space group P21212, with cell parameters a = 104.9, b = 80.0, c = 45.5 ? and a single subunit in the asymmetric unit. The elucidation of the three-dimensional structure of this enzyme will provide a structural framework for this novel class of dehydrogenases to enable a comparison to be made with other enzyme families and also as the basis for mutagenesis experiments directed towards the production of natural and synthetic opine-type compounds containing two chiral centres. 相似文献
2.
Yugang Liu Mahavir Prashad Oljan Repi
Thomas J. Blacklock 《Journal of heterocyclic chemistry》2003,40(4):713-716
Palladium‐catalyzed amination of 7‐bromo‐4‐methyl‐2,1,3‐benzothiadiazole ( 7 ) with benzophenone imine as an ammonia equivalent is described as a new, safe and practical alternative to nitration for the synthesis of 7‐amino‐4‐methyl‐2,1,3‐benzothiadiazole ( 1 ) in high yield. This methodology was successfully scaled‐up in the pilot plant on 14.0‐kg scale of 7 and was also utilized for the synthesis of 7‐amino‐4,6‐dimethyl‐2,1,3‐ben‐zothiadiazole ( 12 ) by the amination of 7‐bromo‐4,6‐dimethyl‐2,1,3‐benzothiadiazole ( 10 ). 相似文献
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A short, stereoselective synthesis of (±)-warburganal (), its C-9 epimer () and the related sesquiterpene dialdehyde (±)-isotadeonal is presented. 相似文献
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Liladhar Waykole Mahavir Prashad Stephen Palermo Oljan Repic Thomas J. Blacklock 《合成通讯》2013,43(12):2159-2163
A practical synthesis of 2-(bromomethyl)naphthalene (1), by selective benzylic bromination of 2-methylnaphthalene (2), with bromine in heptane in the presence of lanthanum acetate hydrate is described. 相似文献
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Yansong J. Lu Bin Hu Mahavir Prashad Shaum Kabadi Oljan Repi
Thomas J. Blacklock 《Journal of heterocyclic chemistry》2006,43(4):1125-1127
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Lech Ciszewski Daquiang Xu Oljan Repi? Thomas J. Blacklock 《Tetrahedron letters》2004,45(43):8091-8093
A highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas by the reductive alkylation of N-monosubstituted thioureas with aldehydes is described. N-Monosubstituted thioureas can in turn be synthesized by the reductive amination of thiourea with an appropriate aldehyde. This reductive alkylation methodology was also extended to carbamates. 相似文献
9.
Goerge T. Lee Andrew Kucerovy Kapa Prasad Oljan Repic Thomas J. Blacklock 《合成通讯》2013,43(21):4009-4018
A simple and efficient γ-acetamidopropylation of different nucleophiles using oxazine 3 has been developed. Deacetylation of acetamides with titanium(IV) isopropoxide/diphenylsilane is also described. 相似文献
10.
Mahavir Prashad Bin Hu Hong-Yong Kim Denis Har Oljan Repi? Thomas J. Blacklock 《Tetrahedron letters》2007,48(12):2087-2089
A new reaction of N-aryl-2-pyrimidinamines with triphosgene to afford N-aryl-N-(2-pyrimidinyl)-2-pyrimidinamine is described. 相似文献