Electrochemical sensor for rutin detection based on Au nanoparticle-loaded helical carbon nanotubes

The key step in the fabrication of highly active electrochemical sensors is seeking multifunctional nanocomposites as electrode modified materials. In this study, the gold nanoparticle-decorated helical carbon nanotube nanocomposites (AuNPs-HCNTs) were fabricated for rutin detection because of its superior sensitivity, the chemical stability of AuNPs, and the superior conductivity and unique 3D–helical structure of helical carbon nanotubes. Results showed the prepared nanocomposites exhibited superior electrocatalytic activity towards rutin due to the synergetic effects of AuNPs and HCNTs. Under the optimized conditions, the developed sensor exhibited a linear response range from 0.1 to 31 μmol/L for rutin with a low detectable limit of 81 nmol/L. The proposed method might offer a possibility for electrochemical analysis of rutin in Chinese medical analysis or serum monitoring owing to its low cost, simplicity, high sensitivity, good stability, and few interferences against common coexisting ions in real samples.     

气相色谱仪检定方法要点和注意事项

为保证气相色谱仪检定工作规范、检定结果准确可靠,基于JJG 700—2016 《气相色谱仪检定规程》提出了检定方法要点和注意事项。探讨了检定前的准备工作,包括确定标准物质和检定项目、气相色谱柱的选用、仪器和色谱柱的准备,整理了检定中仪器条件及程序设置、手动进样操作要点、问题排查等,提出了检定信息记录和数据处理等注意事项。为规范和高效地完成气相色谱仪检定工作提出有效建议,望对提高气相色谱仪检定人员技术水平,提高检定的规范性和准确可靠性提供帮助。     

新型哌嗪并[2,1-a]异喹啉类化合物合成及抗真菌活性的研究

设计、合成了36个新型哌嗪并[2,1-a]异喹啉类化合物,并测试了其体外抗真菌活性.结果表明所有化合物对5种临床致病真菌都有抗真菌活性.其中化合物5h,5j～5l,6g～6k和6l对除白念菌外的4种测试菌的抗真菌活性强于或相当于对照药氟康唑;特别是大多数目标化合物对于氟康唑无效的薰烟曲霉菌显示出较好抗真菌活性.对接研究显示所设计的目标化合物与靶酶活性腔中氨基酸功能残基结合.结果表明新型哌嗪并[2,1-a]异喹啉类化合物是一类全新结构类型的抗真菌化合物,为抗真菌药物研究提供了新的结构类型.     

气态二聚体[C1~6mim]2[BF4]2纳米微观结构的理论研究

在B3LYP/6-311+G(d,p)的水平上采用密度泛函理论研究了[C_nmim]+(n=1~6)与[BF_4]~ˉ形成二聚体[C_nmim]_2[BF_4]_2(n=1~6)的微观纳米结构。通过理论计算二聚体的相互作用能量发现,阴阳离子之间存在较强的氢键作用,且随着咪唑鎓烷基链的增加相互作用能也随之增加,另外,烷基侧链的长度会影响氢键强度。当咪唑鎓烷基侧链中C的个数大于4时,烷基尾部能够发生聚合,从而形成类胶束纳米结构。通过对自然布居分析、自然键轨道以及弱相互作用的分析和计算,同样证明了二聚体中存在较强的氢键作用,烷基侧链中碳的个数影响了离子液体的微观结构。     

An unexpected synthesis and application of ethyl 2,4-bis(chloromethyl)-6-iodoquinoline-3-carboxylate

Research on Chemical Intermediates - An unexpected and direct synthesis of ethyl 2,4-bis(chloromethyl)-6-iodoquinoline-3-carboxylate (3) from the chlorotrimethylsilane (TMSCl)-promoted...