Room‐Temperature Ionic Liquid–Promoted Williamson's Synthesis of Ethers: A Facile Synthesis of Diaryloxymethanes

A simple and efficient method has been developed for the synthesis of phenolic ethers using room‐temperature ionic liquid, not only as solvent but also as promoter. Ionic liquid was recycled and subsequently reused without any loss of the product.     

Molecular iodine catalyzed coupling reactions of indole with 1,3-dicarbonyl compounds

The molecular iodine-catalyzed direct coupling of indoles with 1,3-dicarbonyl compounds is described. This new method for C–C bond formation allows high functional group tolerance, regioselectivity, and scope under mild conditions.     

Stereoselective synthesis ofvic-halohydrins and an unusual Knoevenagel product from an organocatalyzed aldol reaction：A non-enamine mode

Stereoselective synthesis by an aldol reaction between chloroacetone and aldehyde was studied using a synthesized chiral organocatalyst and triethylamine. The reaction gave α-chloro-β-hydroxy ketones in excellent yield with highantiselectivity and enantioselectivity. The chiral organocatalyst was also used in the Knoevenagel reaction, which gave α-cyano-β-hydroxy ketones at a low tem-perature and the usual Knoevenagel product at a high temperature. Both products were obtained in good to moderate yield with goodanti selectivity in the case of α-cyano-β-hydroxy ketone deriva-tives.     

A mild and efficient one-pot synthesis of \upbeta -amino carbonyl compounds via Mannich reaction under ambient temperature condition

We have developed an efficient protocol for the synthesis of $\upbeta $ -amino carbonyl compounds using phenylboronic acid as effective and eco-friendly catalyst via one-pot three-component Mannich reaction. Excellent yields, mild reaction condition, and simple experimental work-up procedure are some of the advantages of this method, which makes it a useful protocol for the synthesis of $\upbeta $ -amino carbonyl compounds.     

Synthesis and Antibacterial Activity of Some 3,5‐Diphenyl and 1,3,5‐Triphenyl‐2‐pyrazolines

Some new 3,5‐diphenyl and 1,3,5‐triphenyl‐2‐pyrazolines derivatives were synthesized by reacting 1,3‐diphenyl‐2‐propen‐1‐ones with hydrazine hydrates and phenyl hydrazine in ethanol. The structural elucidation of the compounds was performed by IR, ¹H NMR and elemental analysis. All examined compounds showed appreciable antibacterial activity.     

Enantioselective organocatalytic synthesis of the chiral chromenes by domino oxa-Michael-aldol reaction

The proline based chiral organocatalyst has been found to be an efficient catalyst for enantioselective domino oxa-Michael-aldol reaction. This catalytic system provided the synthesis of substituted 2-aryl-2H-chromenes-3-carbaldehyde in good to high yields (73%–97%) with excellent enantioselectivity (up to 97%) and reasonable reaction times. The atom economy, high yield and mild reaction conditions are some of the important features of this protocol.     

Synthesis and bioactivities of some new 1H-pyrazole derivatives containing an aryl sulfonate moiety

A new series of 1H-pyrazole derivatives 5a-j bearing an aryl sulfonate moiety have been synthesized by a one-pot cyclo-condensation reaction of 2-(3-(dimethylamino)acryloyl)phenyl-4-methyl benzene sulfonates 4a-e and hydrazine hydrate or phenyl hydrazine in ethanol under reflux conditions.Some of the newly synthesized compounds were screened for their anti-inflammatory activity.All synthesized compounds were screened against Gram positive and Gram negative bacterial and fungal strains.The compound 5b was found to be a potent anti-inflammatory agent while the majority of the compounds were found to be active against microbial strains.     

A convenient one-pot three component synthesis of 3-aminoalkylated indoles catalyzed by 3-chlorophenylboronic acid

An efficient protocol was developed for the synthesis of 3-aminoalkylated indoles using 3-chlorophenylboronic acid as a catalyst under ambient temperature conditions. The three-component reaction of indoles, aromatic aldehydes and N-methyl aniline offered corresponding 3-aminoalkylated indoles in excellent yields. This protocol presents some remarkable features such as mild reaction conditions, simple workup procedure and excellent yields.     

Synthesis and application of proline based organocatalyst for highly enantioselective aldol reaction by hydrogen bonding

Using hydrogen bond based concept we have synthesized new organocatalysts and have applied them to catalyze direct asymmetric aldol reaction. Reaction proceeded efficiently and gave high yield with excellent diastereoselectivity and enantioselectivity.