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1.
Expeditious new syntheses of the title compounds, which are potent glycosidase inhibitors, have been developed based on a high-yield, ring-forming aminomecuration. 相似文献
2.
The glucuronic acid analog 5 of 1-deoxynojirimycin has been synthesized in good overall yield from D-glucose. 相似文献
3.
R Bonfiglio RC King TV Olah K Merkle 《Rapid communications in mass spectrometry : RCM》1999,13(12):1175-1185
A post-column infusion system was developed in order to analyze suppression of electrospray ionization (ESI) tandem mass spectrometry response in the presence of endogenous plasma interferences. By enabling direct detection of these interfering components, this experimental system was used to analyze the ability of several common extraction procedures to remove endogenous plasma components that cause changes in the ESI response of model drug substances. Methyl-t-butyl ether (MTBE) liquid-liquid, Oasis and Empore solid-phase, and acetonitrile (ACN) protein precipitation sample preparation methods were tested using the post-column infusion system. In all cases, ACN protein precipitation samples showed the greatest amount of ESI response suppression while liquid-liquid extracts demonstrated the least. In addition, the three test compounds, phenacetin, caffeine, and a representative Merck compound, demonstrated that ESI response suppression is compound dependent. Suppression was greatest with caffeine, the most polar analyte, and the smallest for the Merck compound, the least polar analyte. Copyright 1999 John Wiley & Sons, Ltd. 相似文献
4.
Samit Mandal J Gerl H Geissel K Hauschild M Hellström Z Janas I Kojouharov Y Kopatch RC Lemmon P Mayet Z Podolyak PH Regan H Schaffner C Schlegel J Simpson HJ Wollersheim 《Pramana》2001,57(1):161-164
Feasibility of gamma-ray spectroscopy at relativistic energies with exotic heavy-ions and new generation of germanium detectors
(segmented Clover) is discussed. An experiment with such detector array and radioactive is discussed. 相似文献
5.
Expeditious routes to 1,2,3,4,4a,5-hexahydro-pyrazino[2,1-c][1,4]benzothiazine-6,6-dioxide, a methylenesulfone-constrained arylpiperazine, have been developed. The key step forms the tricyclic system in a cascade of reactions via a 1,4-addition, nitrogen alkylation, and aromatic substitution sequence. 相似文献
6.
We report measurements of non-linear charge transport in epitaxial (La1−x
Pr
x
)0.7Ca0.3MnO3 thin films fabricated on (100) oriented SrTiO3 single crystals by pulsed laser deposition. The end members of this series, namely Pr0.7Ca0.3MnO3 and La0.7Ca0.3MnO3 are canonical charge-ordered (CO) and ferromagnetic manganites, respectively. The onset of the CO state in Pr0.7Ca0.3MnO3 is manifested by a pronounced insulating behavior below ∼ 200 K. The CO state remains stable even when a large (∼ 2×105 V/cm) electric field is applied across the thin film samples. However, on substitution of Pr with La, a crossover from the
highly resistive CO state to a state of metallic character is observed at relatively low electric fields. The current-voltage
characteristics of the samples at low temperatures show hysteretic and history dependent effects. The electric field driven
charge transport in the system is modelled on the basis of an inhomogeneous medium consisting of ferromagnetic metallic clusters
dispersed in a CO background. 相似文献
7.
MA Freitas SR Dillon RC Dougherty AG Marshall 《Rapid communications in mass spectrometry : RCM》1999,13(15):1622-1625
The self-chemical ionization of diethylzinc is examined by Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry and semiempirical molecular orbital calculations. Electron impact of diethylzinc neutral produces the radical cation, C(4)H(15)Zn(+) (m/z x 122), which reacts further with the neutral (C(2)H(5))(2)Zn to give the following product ions: Zn(+) (m/z x 64), C(2)H(5)Zn(+) (m/z x 93), C(4)H(9)Zn(+) (m/z x 121), C(4)H(11)Zn(2)(+) (m/z x 187), and C(6)H(15)Zn(2)(+) (m/z x 215). To determine the structure and pathways for production of these ions, monoisotopic (12)C(4)H(15)(64)Zn(+), (64)Zn(+) and (12)C(2)H(5)(64)Zn(+) were individually isolated and reacted with the neutral background. We also performed semiempirical molecular orbital calculations (ZINDO/1). The molecular orbital calculations and experimental data are consistent in predicting that the ethyl group on the diethylzinc cation carries the positive charge. Copyright 1999 John Wiley & Sons, Ltd. 相似文献
8.
A series of oxazolidine-4,5-diones 2 was thermally cleaved to cyclic imines 3 in excellent yield. This reaction was utilized in an efficient synthesis of a 3,4-dihydroisoquinoline-based nitrone 1b. 相似文献
9.
The coefficients of fractional parentage (CFP ), treated by tradition as antisymmetrizing multipliers, do not exist as such in the second-quantization representation, because, therein, by definition, there is nothing to antisymmetrize. This by no way means that the above-mentioned representation is less relevant in theoretical atomic spectroscopy than is any other one. On the contrary, all the well-known mathematical apparatus is still successfully applied, alongside with numerous new useful features. Moreover, the analysis presented here yields some results not so obvious from the point of view of the coordinate representation, namely, the consequent application of the second-quantization representation led us to an expansion of many-shell wave functions employing analogs of many-shell CFP , which appeared to be considerably simpler than the traditional CFP expansion. Also, a generalization of Redmond's formula for the case of many-shell CFP and a straightforward method of deriving summation rules for products of CFP are clear in the second-quantization representation and are sketched here. © 1994 John Wiley & Sons, Inc. 相似文献
10.