Preparation and Insecticidal Activity of the First Organofluorine Insecticide Based on β-D-Ribofuranoside Monosaccharide

Russian Journal of General Chemistry - A method was developed for the synthesis of an organofluorine derivative of β-D-ribofuranoside. Biological tests revealed high insecticidal activity and...     

Methyl 2,3‐dideoxy‐2‐S‐methylmercurio‐2‐thio‐β‐d‐manno‐oct‐2‐ulo­pyranosonate‐(2,6)

The hexo­pyran­osyl ring of the title compound, [Hg(CH₃)(C₉H₁₅O₇S)], adopts the ⁴C₁ chair conformation, and the anomeric configuration of the thio­methyl­mercury linkage is β. The compound exists as two symmetry‐independent conformers, A and B, within the unit cell, and each shows an almost linear S—Hg—C arrangement. Most of the bond distances and angles in A and B are similar, although a marked difference exists in the side‐chain conformation. Weak secondary intramolecular (between Hg and ring O) and intermolecular (between A and B conformers) interactions are documented.     

Syntesis, antifungal and antiviral activity of hydrophosphoryl derivatives of lucensomycin

A reaction of polyene macrolide antibiotic, lucensomycin, with aromatic aldehydes and hypophosphorous acid results in formation of its hydrophosphoryl derivatives. Physicochemical and biomedical properties of the synthesized lucensomycin derivatives were studied. Biological examination showed that hydrophosphoryl lucensomycin derivatives were less toxic medicines than original antibiotic and they are of higher antifungal and antiviral activity.     

Results of Examination of the Biological Activity of Nonmedical Antibiotics with a View to Finding Environmentally Friendly Pesticides for Plant Protection

Russian Journal of General Chemistry - Biological experiments with nonmedical antibiotics lucensomycin, tetramycins A and B, aureofungins A and B, and antimycin A were carried out. These...     

The application of mycelial wastes from microbiological production of antibacterial antibiotics as lubricating oil additives

The antiwear and antitear properties of mycelial wastes from production of antibacterial antibiotics have been studied. The waste mycelium from fucidin production has been shown to exhibit the best antiwear and antitear performance due to a higher percentage content of phosphorus and sulfur as compared to the mycelial wastes from production of other antibacterial antibiotics.     

Synthesis of hydrophospohoryl derivatives of the antifungal antibiotic pimaricin by the Kabachnik-Fields reaction

Reactions of the polyene macrolide antibiotic pimaricin with aromatic aldehydes and hypophosphorous acid are shown to afford pimaricin hydrophosphoryl derivatives. Physicochemical and biological properties of these compounds are explored. Biological studies indicated that the pimaricin hydrophosphoryl derivatives are low toxic agents possessing a high antifungal activity. The text was submitted by authors in English.     

Synthesis and Insecticidal Activity of 5-C-Phosphonate Derivatives of Aryl-1-thio-β-D-ribofuranoside

Russian Journal of General Chemistry - The method of synthesis of phosphonate derivatives of β-D-ribofuranoside was developed. Biological tests showed that prepared compounds possess high...     

Ecological Aspects of Application of Tetraene Macrolide Antibiotic Tetramycin in Agriculture and Food Industry (A Review)

Russian Journal of General Chemistry - Published data on the preparation, physicochemical properties, chemical structure, and biological activity of tetraene macrolide antibiotic tetramycin were...     

The application of microfine ionites for the improvement of the efficiency of sorption processes in drug production (Review)

Results of the application of microfine ionites of different classes for sorption methods in the production of versatile drugs are systemized. Kinetic and dynamic parameters of sorption isolation and chemical purification of drugs with participation of ion-exchanger of small graining are discussed; essential advantages of their application allowing intensification of ion-exchange technological processes of drugs production are determined. The review can be useful at elaboration of new sorption methods used for the production of the wide assortment of drugs and, first of all, antibiotics, enzymes, and vitamins.