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G.L. Baskerville 《Natural Resource Modeling》1988,2(4):669-671
ADAPTIVE MANAGEMENT OF RENEWABLE RESOURCES, Carl Walters, MacMillan Publishing Co New York, Collier MacMillan Publishers London, 1986, 374pp ISBN 0-02-947970-3 相似文献
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Summary In vitro selection, or SELEX, has been used both to characterize the interaction of natural nucleic acids with proteins and to generate novel nucleic acid-binding species, or aptamers. Although numerous reports have demonstrated the power of the technique, they have not expanded on the methodologies that can be used for selection. This review focuses on the considerations and problems involved in selecting protein-binding aptamers from a random-sequence RNA pool. As an illustration, we describe two approaches to selecting aptamers to a particular target, the HTLV-I Rex protein. In the first, complete randomization is used to find an artificial, high-affinity RNA binding site. In the second, the contributions of individual nucleotides and/or base pairs to the natural Rex-binding element are determined by mutating the wild-type sequence and selecting active binding variants. 相似文献
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B. C. Brodie R. Luther J. K. H. Inglis O. Brunck F. P. Treadwell E. Anneler G. Lechner E. Czakó L. Ubbelohde P. Malaquin M. Hofsäss R. Nasini C. Porlezza Ch. Baskerville W. J. Crozier F. Krüger M. Moeller V. Rothmund A. Burgstaller und H. Brach 《Fresenius' Journal of Analytical Chemistry》1914,53(1):41-47
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Charles Baskerville 《Fresenius' Journal of Analytical Chemistry》1904,43(10):640
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