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Research on Chemical Intermediates - Cobalt ferrite is a promising material for many therapeutic applications, photo-catalysis, gas detectors, high-density data storage, etc. Optimization of...  相似文献   
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A cobalt-catalyzed 1,4-aryl migration/disulfonylation cascade applied to α-bromo N-sulfonyl amides was developed. The reaction was highly chemoselective, allowing the preparation of α-aryl amides possessing a variety of functional groups. The method was used as the key step to synthesize an alkaloid, (±)-deoxyeseroline. Mechanistic investigations suggest a radical process.  相似文献   
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Protein turnover critically influences many biological functions, yet methods have been lacking to assess this parameter in?vivo. Here, we demonstrate how chemical labeling of SNAP-tag fusion proteins can be exploited to measure the half-life of resident intracellular and extracellular proteins in living mice. First, we demonstrate that SNAP-tag substrates have wide?bioavailability in mice and can be used for the specific in?vivo labeling of SNAP-tag fusion proteins. We then apply near-infrared probes to perform noninvasive imaging of in?vivo-labeled tumors. Finally, we use SNAP-mediated chemical pulse-chase labeling to perform measurement of the in?vivo half-life of different extra- and intracellular proteins. These results open broad perspectives for studying protein function in living animals.  相似文献   
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