Concepts and realization of microstructure heat exchangers for enhanced heat transfer

Microstructure heat exchangers have unique properties that make them useful for numerous scientific and industrial applications. The power transferred per unit volume is mainly a function of the distance between heat source and heat sink—the smaller this distance, the better the heat transfer. Another parameter governing for the heat transfer is the lateral characteristic dimension of the heat transfer structure; in the case of microchannels, this is the hydraulic diameter. Decreasing this characteristic dimension into the range of several 10s of micrometers leads to very high values for the heat transfer rate.

Another possible way of increasing the heat transfer rate of a heat exchanger is changing the flow regime. Microchannel devices usually operate within the laminar flow regime. By changing from microchannels to three dimensional structures, or to planar geometries with microcolumn arrays, a significant increase of the heat transfer rate can be achieved.

Microheat exchangers in the form of both microchannel devices (with different hydraulic diameters) and microcolumn array devices (with different microcolumn layouts) are presented and compared. Electrically heated microchannel devices are presented, and industrial applications are briefly described.     

Design and Experimental Investigation of a Gas-to-Gas Counter-Flow Micro Heat Exchanger

In this work, a double-layered microchannel heat exchanger is designed for investigation on gas-to-gas heat transfer. The micro-device contains 133 parallel microchannels machined into a polished polyether ether ketone plate for both the hot side and cold side. The microchannels are 200 μm high, 200 μm wide, and 39.8 mm long. The design of the micro-device allows tests with partition foils in different materials and of flexible thickness. A test rig is developed with the integration of customized pressure and temperature sensors for in situ measurements. Experimental tests on the counter-flow micro heat exchanger have been carried out for five different partition foils and various mass flow rates. The experimental results, in terms of pressure drop, heat transfer coefficients, and heat exchanger effectiveness are discussed and compared with the predictions of the classic theory for conventionally sized heat exchangers.     

Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases

Ene reductases from the Old Yellow Enzyme (OYE) family reduce the C=C double bond in α,β‐unsaturated compounds bearing an electron‐withdrawing group, for example, a carbonyl group. This asymmetric reduction has been exploited for biocatalysis. Going beyond its canonical function, we show that members of this enzyme family can also catalyze the formation of C?C bonds. α,β‐Unsaturated aldehydes and ketones containing an additional electrophilic group undergo reductive cyclization. Mechanistically, the two‐electron‐reduced enzyme cofactor FMN delivers a hydride to generate an enolate intermediate, which reacts with the internal electrophile. Single‐site replacement of a crucial Tyr residue with a non‐protic Phe or Trp favored the cyclization over the natural reduction reaction. The new transformation enabled the enantioselective synthesis of chiral cyclopropanes in up to >99 % ee.     

Influence of Fluid Flow Distribution in Micro-Channel Arrays to Phase Transition Processes

Microstructured heat exchangers are well suited for such phase transition processes as evaporation of liquids due to their heat transfer capabilities, being two to three orders of magnitude higher than those of conventional heat transfer devices. Controlling liquid evaporation inside micro-channels to provide full evaporation in a stable way is not trivial. In most cases, such instabilities as slug flow, bubbly flow, or vapor clogging occur, based on cross-talk possibilities between the individual micro-channels of a channel array, normally caused by open void inlet structures. Therefore, fluid inlet distribution is inhomogeneous, which results, in the best case, in a parabolic shape of a stable evaporation frontline. The parabolic shape occurs due to the residence time distribution of the fluid, generated by shorter path length in the array center and longer ones in the outer areas of the micro-channel array. Computational fluid dynamics simulation approves this result. Such a frontline can be kept stable when the process parameters are well controlled. Small deviations of the inlet parameters may lead to strong disturbances of the evaporation process, destabilizing it. When changing the inlet fluid distribution system to provide the most equal flow distribution possible, the span of the parabolic shape of the evaporation frontline can be reduced drastically. Finally, a stable evaporation frontline perpendicular to flow direction can be obtained. This status is no longer very sensitive to process deviations.

This article presents an optimized micro-channel device for the optical investigation of phase transition phenomena. The device allows the exchange of integrated micro-channel arrays to investigate different designs for their suitability. It is separated into three independent sections, which can be heated or cooled individually. Therefore, very strict and rapid temperature jumps can be obtained within relatively short distances. The micro-channel array foils used for the experiments have been manufactured by mechanical micro-machining. Thus, the cross-sections of the micro-channels are always rectangular. Hydraulic diameter and length of the micro-channels, as well as the shape of the inlet and outlet voids, can be varied. Using a simple triangular or rectangular open inlet void, a stable evaporation line was generated, showing a parabolic shape. Depending on the mass flow and the size and shape of the inlet void, the span of the parabolic arc was influenceable.     

Promotion of wound healing by Plantago major L. leaf extracts – ex-vivo experiments confirm experiences from traditional medicine

The wound-healing properties of Plantago major L. (plantain) were evaluated using an ex-vivo porcine wound-healing model. Ethanol- and water-based extracts were prepared from greenhouse-grown and freeze-dried leaves of P. major. Both types of extracts stimulated wound healing in porcine skin, but the ethanol-based extracts had a somewhat stronger effect. A concentration of 1.0 mg/mL (on dry weight basis) produced the best results for both types of extracts.     

Microfabrication in metals, ceramics and polymers

In this overview report fabriation of microconstructed devices and systems out of metals, ceramics and polymers will be presented briefly as well as bonding, sealing and packaging of devices. The main objective for the systems and divices covered here is chemical process engineering, thud, metal, ceramic, and polymer manufacturing techniques are considered, while silicon technology is itentionally left out, because this technology is normally not used in this tipoc. The text will only provide a rough overview onto the numerous techniques and technologies.     

A memetic approach to construct transductive discrete support vector machines

Transductive learning involves the construction and application of prediction models to classify a fixed set of decision objects into discrete groups. It is a special case of classification analysis with important applications in web-mining, corporate planning and other areas. This paper proposes a novel transductive classifier that is based on the philosophy of discrete support vector machines. We formalize the task to estimate the class labels of decision objects as a mixed integer program. A memetic algorithm is developed to solve the mathematical program and to construct a transductive support vector machine classifier, respectively. Empirical experiments on synthetic and real-world data evidence the effectiveness of the new approach and demonstrate that it identifies high quality solutions in short time. Furthermore, the results suggest that the class predictions following from the memetic algorithm are significantly more accurate than the predictions of a CPLEX-based reference classifier. Comparisons to other transductive and inductive classifiers provide further support for our approach and suggest that it performs competitive with respect to several benchmarks.     

The Steady-State ALTADENA RASER Generates Continuous NMR Signals**

A RASER (Radio Amplification by Stimulated Emission of Radiation) facilitates the study of nonlinear phenomena, as well as the determination of NMR parameters with high precision. To achieve maximum sensitivity in the desired operating mode, it is crucial to control the RASER over long periods of time. So far, this was only possible at ultra-low magnetic fields. Here, we introduce a way to control the operating regime of a RASER at a magnetic field of 1.45 T. We employ a continuous-flow RASER, pumped by PHIP (ParaHydrogen Induced Polarization). The hydrogenation of vinyl acetate (VA) with parahydrogen provides the required negative polarization on the methyl group of the product ethyl acetate (EA). The protons within the methyl group, separated by a 7 Hz J-coupling, are RASER active. This system demonstrates five RASER phenomena: inequivalent and equivalent amplitudes in the “normal NMR mode”, period doublings, frequency combs, and chaos. The experiments match with simulations based on a theoretical model of two nonlinear-coupled RASER modes. We predict the RASER regime at set conditions and visualize the prediction in a bifurcation diagram.