N-butyl-,N-iso-butyl-andN-sec-butyl-2-picolinamineN-oxide complexes derived from copper(II) salts of polyatomic anions

Summary N-butyl-,N-iso-butyl- andN-sec-butyl-2-picolinamineN- oxide complexes have been prepared from copper(II) perchlorate, tetrafluoroborate and nitrate. Violet solids were isolated from the first two salts while complexes isolated from the nitrate salt were blue green or blue. The ligands coordinatevia both theN-oxide oxygen and the amine nitrogen to give bis (ligand) complexes and only in the case of the nitrate solids is there interaction between the copper(II) centre and the polyatomic anion. Resolution of the g feature in the powder spectra of several of these complexes results from the bulkiness of the butyl groups and therefore dilution of the copper(II) centers. In comparison to the previously studied 2 picolinamineN-oxides with lower alkyl substituents, the complexes have stronger in-plane bonding by the ligands.NATO Fellow on leave from Istanbul Medical Faculty, Istanbul University.     

A new affinity-HPLC packing for protein separation: Cibacron blue attached uniform porous poly(HEMA-<Emphasis Type="Italic">co</Emphasis>-EDM) beads

In this study, a new affinity high-performance liquid chromatography (HPLC) stationary phase suitable for protein separation was synthesized. In the first stage of the synthesis, uniform porous poly(2-hydroxyethyl methacrylate-co-ethylene dimethacrylate), poly(HEMA-co-EDM), beads 6.2 μm in size were obtained. Homogeneous distribution of hydroxyl groups in the bead interior was confirmed by confocal laser scanning microscopy. The plain poly(HEMA-co-EDM) particles gave very low non-specific protein adsorption with albumin. The selected dye ligand Cibacron blue F3G-A (CB F3G-A) was covalently linked onto the beads via hydroxyl groups. In the batch experiments, albumin adsorption up to 60 mg BSA/g particles was obtained with the CB F3G-A carrying poly(HEMA-co-EDM) beads. The affinity-HPLC of selected proteins (albumin and lysozyme) was investigated in a 25 mm×4.0-mm inner diameter column packed with CB F3G-A carrying beads and both proteins were successfully resolved. By a single injection, 200 μg of protein was loaded and quantitatively eluted from the column. The protein recovery increased with increasing flow rate and salt concentration of the elution buffer and decreased with the increasing protein feed concentration. During the albumin elution, theoretical plate numbers up to 30,000 plates/m were achieved by increasing the salt concentration.     

Preparation and characterization of Co(II), Ni(II) and Cu(II) complexes of a ligand containing 1,3,4-thiadiazole groups

(1R,2R)-1,2-bis-(5-amino-1,3,4-thiadiazole-2-yl)ethane-1,2-diol (L) has been prepared by the reaction of thiosemicarbazide with (2R,3R)-(+)-tartaric acid (I) and phosphorous oxychloride, and its complexes with Co(II), Ni(II) and Cu(II) have been obtained. The structures of the ligand and its complexes have been established by i. r., ¹H- and ¹³C-n.m.r. spectra, u.v.–vis–nir spectroscopy, elemental analyses, T.g.-D.t.a. and magnetic susceptibility measurements.     

Green’s Functional for Higher-Order Ordinary Differential Equations with General Nonlocal Conditions and Variable Principal Coefficient

Ukrainian Mathematical Journal - The method of Green’s functional is a little-known technique for the construction of fundamental solutions to linear ordinary differential equations (ODE)...     

Anticancer activities of manganese-based photoactivatable CO-releasing complexes (PhotoCORMs) with benzimidazole derivative ligands

Carbon monoxide is an important signaling molecule which is produced by heme oxygenase-1. CO shows antiproliferative activity against cancer cells; hence, activation of HO-1 is a significant inhibition strategy against tumor formation and survival of cancer cells. In this work, manganese-based CO-releasing molecules (CORMs) were designed and synthesized to inhibit breast cancer cell proliferation. Human invasive ductal breast cancer cells (MCF-7) were treated with the synthesized CORMs to investigate the effect of the complexes on breast cancer survival under UV light. In vitro experiments indicated that the complexes inhibited breast cancer cell proliferation, and further, the antiproliferative effects were increased under UV light. Thus, these novel CORMs may provide a drug template for the treatment of invasive ductal breast cancer.     

Discrete Gradient Method: Derivative-Free Method for Nonsmooth Optimization

A new derivative-free method is developed for solving unconstrained nonsmooth optimization problems. This method is based on the notion of a discrete gradient. It is demonstrated that the discrete gradients can be used to approximate subgradients of a broad class of nonsmooth functions. It is also shown that the discrete gradients can be applied to find descent directions of nonsmooth functions. The preliminary results of numerical experiments with unconstrained nonsmooth optimization problems as well as the comparison of the proposed method with the nonsmooth optimization solver DNLP from CONOPT-GAMS and the derivative-free optimization solver CONDOR are presented.     

The optical properties of a novel metal-free phthalocyanine

In the present work, 4-(4′-dodecyloxycarbonyl) phenoxy phthalonitrile was synthesized and then this phthalonitrile derivative was cyclotetramerized in dodecanol resulting a new metal-free phthalocyanine. The optical properties of this phthalocyanine were investigated. Novel metal-free phthalocyanine thin films were deposited on indium tin oxide-coated glass substrates by spinning method. Surface and microstructural properties of the films were characterized by atomic force microscopy and scanning electron microscopy. Both the transmittance and reflectance spectra of the deposited films were recorded using an NKD analyser. The optical band gap energy, the thickness of thin films, refractive index (n) and extinction coefficient (k) were calculated as 2.7 eV, 300 nm, 1.47 and 0.02, respectively.     

Synthesis,Spectroscopic Studies and Structure of 2-[(Benzo[<Emphasis Type="Italic">d</Emphasis>]thiazol-2-ylamino)methyl]phenol

Abstract  

Schiff base (E)-2-[(benzo[d]thiazol-2-ylimino)methyl]phenol (1) has been synthesized from the reaction of 2-hydroxy-benzaldehyde with 2-aminobenzothiazole. The 2-[(benzo[d]thiazol-2-ylamino)methyl]phenol (2) was prepared reduction of the Schiff base 1 with sodium borohydride. The compounds 1 and 2 have been characterized by elemental analysis, FT-IR, ¹H-NMR, ¹³C-NMR and UV–visible spectroscopic techniques. The structure of the compound 2 has also been examined crystallographically. The compound 2 crystallizes in the monoclinic space group P2/c. The unit cell parameters were found as a = 10.017(1), b = 11.725(1), c = 10.341(1) ?, V = 1208.1(1) ?³, D _x = 1.409 g cm⁻³ and Z = 4. The crystal structure was solved by direct methods and refined by the full-matrix least squares method and found as R ₁ = 0.0308 and wR ₂ = 0.0818 for 2032 for the observed reflections [I > 2σ(I)].