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1.
Kusano G Orihara S Tsukamoto D Shibano M Coskun M Guvenc A Erdurak CS 《Chemical & pharmaceutical bulletin》2002,50(2):185-192
Investigation of the constituents of the fruits of Morus alba LINNE (Moraceae) afforded five new nortropane alkaloids (1-5) along with nor-psi-tropine (6) and six new amino acids, morusimic acids A-F (7-12). The structures of the new compounds were determined to be 2alpha,3beta-dihydroxynortropane (1), 2beta,3beta-dihydroxynortropane (2), 2alpha,3beta,6exo-trihydroxynortropane (3), 2alpha,3beta,4alpha-rihydroxynortropane (4), 3beta,6exo-dihydroxynortropane (5), (3R)-3-hydroxy-12-[(1S,4S)-4-[(1S)-1-hydroxyethyl]-pyrrolidin-1-yll-dodecanoic acid-3-O-beta-D-glucopyranoside (7), (3R)-3-hydroxy-12-[(1S,4S)-4-[(1S)-1-hydroxyethyl]-pyrrolidin-1-yll-dodecanoic acid (8), (3R)-3-hydroxy-12-1(1R,4R,5S)-4-hydroxy-5-methyl-piperidin-1-yll-dodecanoic acid-3-O-beta-D-glucopyranoside (9), (3R)-3-hydroxy-12-[(1R,4R,5S)-4-hydroxy-5-methyl-piperidin-1-yll-dodecanoic acid (10), (3R)-3-hydroxy-12-[(1R,4R,5S)-4-hydroxy-5-hydroxymethyl-piperidin-1-yl]-dodecanoic acid-3-O-beta-D-glucopyranoside (11), and (3R)-3-hydroxy-12-[(1R,4S,5S)-4-hydroxy-5-methyl-piperidin-1-yl]-dodecanoic acid (12) on the basis of spectral and chemical data. 相似文献
2.
The quantification of methyldopa in pharmaceuticals has been carried out using a glassy carbon electrode(GCE) modified with multi-walled carbon nanotubes(MWCNTs). Methyldopa exhibited a quasi-reversible response with a peak potential separation of 473 m V on a bare GCE. However, the cyclic voltammetric behaviour of methyldopa was improved with the increase of the amount of MWCNTs. It was also shown that the electrocatalytic activity of the electrode towards the response of methyldopa was higher with larger amount of film on the surface. The results showed that the peak current was proportional to the concentration of methyldopa with a linear dynamic range of 0.005–0.388 mmol/L and a detection limit of 1.0 nmol/L was obtained using square wave voltammetry. The experimental data showed that the detection limit of methyldopa and peak separation from interfering compounds such as ascorbic acid(AA) and uric acid(UA) were improved using the proposed procedure. The method was successfully applied for the determination of methyldopa in pharmaceuticals. 相似文献
3.
A platform based on praseodymium doped dysprosium oxide-carbon nanofibers modified electrode was constructed for the simultaneous determination of SY and TAR. SEM, EDX and XRD techniques were utilized for characterizing the proposed material. The voltammetric behaviour and properties of SY and TAR were gradually improved at materials in order from CNFs to Dy2O3−CNFs and Pr6O11@Dy2O3−CNFs. The working range was found to be 1.0×10−9–3.5×10−8 M and 1.5×10−9–4.0×10−8 M for SY and TAR, respectively. The value of LOD was 3.12×10−10 M and 5.35×10−10 M for SY and TAR, respectively. The platform (Pr6O11@Dy2O3−CNFs/GCE) was successfully applied to the electroanalysis of samples. 相似文献
4.
Shijie Liu Georg Roeder Gulnur Aygun Kristian Motzek Peter Evanschitzky Andreas Erdmann 《Optik》2012,123(10):928-931
A 3D model is set up to simulate the exposure process of inclined/rotated UV lithography for negative SU-8 resists. The formation of inclined resist pillars and microstructures with truncated cone shapes is simulated based on a 3D exposure model in combination with a post exposure bake model for chemically amplified resists and the Mack development model. As one of the interesting applications employing this promising lithography technique for MEMS fabrication, a solid microneedle for drug delivery is simulated. 相似文献
5.
A novel chiral calix[4](azoxa)crown-7 (9) has been synthesized and its metal ion recognition properties investigated. The starting reagents, chiral diamine 5 and calix[4]arene diacid chloride derivative 8, were prepared according to literature methods. 1H and 13C NMR data show that 9 exists in a cone conformation. In liquid–liquid extraction experiments, 9 exhibits selectivity for Li+ among the other alkali metals and a good extraction ability for transition metal cations, suggesting its potential use in different fields, such as a sensor for ions as well as for chiral molecules. 相似文献
6.
Derya Tarinc Burcu Dogan-Topal Aysegul Golcu Sibel A. Ozkan 《Journal of Analytical Chemistry》2014,69(9):899-908
A voltammetric study of the oxidation of Ceftazidime (CEFT) has been carried out at the glassy carbon electrode by cyclic, differential pulse (DPV) and square wave (SWV) voltammetry. The oxidation of CEFT was irreversible and exhibited diffusion controlled process depending on pH. The oxidation mechanism was proposed and discussed. According to the linear relationship between the peak current and concentration, DPV and SWV voltammetric methods for CEFT assay in pharmaceutical dosage forms and human urine were developed. For analytical purposes, a well resolved diffusion controlled voltammetric peak was obtained in 0.1 M H2SO4 at 1.00 and 1.02 V for differential pulse and square wave voltammetric techniques, respectively. The linear response was obtained within the range of 4 × 10?6?8 × 10?5 M with a detection limit of 6 × 10?7 M for differential pulse and 4 × 10?6–2 × 10?4 M with a detection limit of 1 × 10?6 M for square wave voltammetric technique. The determination of CEFT in 0.1 M H2SO4 was possible over the 2 × 10?6–1 × 10?4 M range in urine sample for both techniques. The standard addition method was used for the recovery studies. 相似文献
7.
Selcuk Denizligil Aysegul Baskan Yusuf Yagci 《Macromolecular rapid communications》1995,16(5):387-391
The polymerization of tetrahydrofuran was initiated with 4,4′-azobis(4-cyanovaleryl chloride) in conjunction with silver hexafluoroantimonate and the living polytetrahydrofuran (PTHF) was terminated with pyridinium N-oxide derivatives. The resulting PTHF-macroinitiator possesses both a thermally and photochemically labile group. 相似文献
8.
Cesme Mustafa Polat Duygu Senel Pelin Golcu Aysegul 《Russian Journal of Electrochemistry》2019,55(4):281-290
Russian Journal of Electrochemistry - In this study, a new biosensor for amisulpride (ASP) determination is defined. The interaction between ASP and fish sperm double-stranded DNA (FSdsDNA) was... 相似文献
9.
Vanadium oxide (VOx) thin film has been widely used for IR detectors and it is one of the promising materials for THz detectors due to its high temperature coefficient of resistance (TCR) values. VOx films with proper TCR values have also high resistance and it restricts bolometer performance especially for uncooled bolometers. To overcome this problem, deposition at elevated temperatures or annealing approach has been accepted and used but gold co-deposition approach has been proposed recently. In this study, vanadium oxide films were fabricated on high resistivity silicon substrates by reactive direct current magnetron sputtering in different O2/Ar atmosphere at room temperature. We investigated influence of oxygen partial pressure during deposition process and fabricated VOx thin films with sufficient TCR values for bolometer applications. In order to decrease resistivity of the deposited films, post annealing and gold doping approaches were performed separately. Effect of both post annealing process and gold doping process on structural and electrical properties of VOx thin films deposited at room temperature were investigated and detailed comparison between these methods were presented. We obtained the best possible approach to obtain optimum conditions for the highly reproducible VOx thin films which have the best resistivity and suitable TCR value for bolometer applications. 相似文献
10.
Aslanoglu M Kutluay A Abbasoglu S Karabulut S 《Chemical & pharmaceutical bulletin》2008,56(3):282-286
A reliable and reproducible method for the determination of uric acid in urine samples has been developed. The method is based on the modification of a glassy carbon electrode by 3-acetylthiophene using cyclic voltammetry. The poly(3-acetylthiophene) modified glassy carbon electrode showed an excellent electrocatalytic effect towards the oxidation of uric acid in 0.1 m phosphate buffer solution (PBS) at pH 7.2. Compared with a bare glassy carbon electrode (GCE), an obvious shift of the oxidation peak potential in the cathodic direction and a marked enhancement of the anodic current response for uric acid were observed. The poly(3-acetylthiophene)/GCE was used for the determination of uric acid using square wave voltammetry. The peak current increased linearly with the concentration of uric acid in the range of 1.25 x 10(-5)-1.75 x 10(-4) M. The detection limit was 5.27 x 10(-7) M by square wave voltammetry. The poly(3-acetylthiophene)/GCE was also effective to determine uric acid and ascorbic acid in a mixture and resolved the overlapping anodic peaks of these two species into two well-defined voltammetric peaks in cyclic voltammetry at 0.030 V and 0.320 V (vs. Ag/AgCl) for ascorbic acid and uric acid, respectively. The modified electrode exhibited stable and sensitive current responses toward uric acid and ascorbic acid. The method has successfully been applied for determination of uric acid in urine samples. 相似文献