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排序方式: 共有161条查询结果,搜索用时 31 毫秒
1.
Jun-ichi Miyachi 《Archiv der Mathematik》2006,86(4):317-320
Let Λ be a left Artinian ring, D+(mod Λ) (resp., D−(mod Λ), D(mod Λ)) the derived category of bounded below complexes (resp., bounded above complexes, unbounded complexes) of
finitely generated left Λ-modules. We show that the Grothendieck groups K0(D+(mod Λ)), K0(D−(mod Λ)) and K0(D(mod Λ)) are trivial.
Received: 7 April 2005 相似文献
2.
In order to investigate the reason why phenylpropanoic acid derivative (KCL), a potent, human peroxisome proliferator-activated receptor (PPAR) alpha-selective agonist, shows this selectivity, we analyzed the binding modes of KCL and a related compound to the ligand-binding domain of human PPARalpha and rat PPARalpha by means of computer-aided molecular modeling. We concluded that the characteristic specificity of KCL is due to a specific hydrophobic contact between the hydrophobic tail part (the 4-trifluoromethyl group) and the key amino acid Ile272 located on the helix three region of the human PPARalpha ligand binding domain. We propose a possible binding mode of KCL with the ligand-binding domain of human PPARalpha. This binding model should offer important insights for further structural design of subtype-selective PPARalpha agonists for the treatment of altered metabolic homeostasis, such as dyslipidemia, obesity, and diabetes. 相似文献
3.
4.
Shimazawa R Sano H Tanatani A Miyachi H Hashimoto Y 《Chemical & pharmaceutical bulletin》2004,52(4):498-499
Thalidomide has been found to exhibit weak nitric oxide synthase (NOS)-inhibitory activity. Structural development studies of thalidomide showed that some N-2,6-dimethylphenylhomophthalimide analogs possess NOS-inhibiting activity. 相似文献
5.
6.
Satoshi Nagao Ayaka Suda Hisashi Kobayashi Naoki Shibata Yoshiki Higuchi Shun Hirota 《化学:亚洲杂志》2020,15(11):1743-1749
Domain swapping is an exception to Anfinsen's dogma, and more than one structure can be produced from the same amino acid sequence by domain swapping. We have previously shown that myoglobin (Mb) can form a domain‐swapped dimer in which the hinge region is converted to a helical structure. In this study, we showed that domain‐swapped dimerization of Mb was achieved by a single Ala mutation of Gly at position 80. Multiple Ala mutations at positions 81 and 82 in addition to position 80 facilitated dimerization of Mb by stabilization of the dimeric states. Domain swapping tendencies correlated well with the helical propensity of the mutated residue in a series of Mb mutants with amino acids introduced to the hinge region. These findings demonstrate that a single mutation in the hinge loop to modify helical propensity can control oligomer formation, providing new ideas to create high‐order protein oligomers using domain swapping. 相似文献
7.
动态核极化法(Dynamic Nuclear Polarization, DNP)是利用热平衡下的电子在磁场中的高自旋极化率转移到原子核自旋的技术,从而极大的提高原子核自旋极化率。多种动态极化靶材料已广泛的用于自旋物理散射实验。本文介绍一种简单实用,共同开发的日本山形大学DNP系统,包括超导磁场,氦4蒸发恒冷器,微波系统以及NMR核磁共振检测系统,测得中子靶材料氘带丁醇(D-butanol)中氘核的极化率在2.5T/1.3K达到+6.5%。 相似文献
8.
Dr. Yasunori Toda Takayuki Yoshida Kaoru Arisue Prof. Dr. Kazuaki Fukushima Dr. Hiroyoshi Esaki Ayaka Kikuchi Prof. Dr. Hiroyuki Suga 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(41):10578-10582
Chiral Lewis acid-catalyzed asymmetric alcohol addition reactions to cyclic carbonyl ylides generated from N-(α-diazocarbonyl)-2-oxazolidinones featuring a dual catalytic system are reported. Construction of a chiral quaternary heteroatom-substituted carbon center was accomplished in which the unique heterobicycles were obtained in good yields with high stereoselection. The alcohol adducts were successfully converted to optically active oxazolidine-2,4-diones by hydrolysis. Mechanistic studies by DFT calculations revealed that alcohols could be activated by Lewis acids, enabling enantioselective protonation of the carbonyl ylides. 相似文献
9.
Ikeda S Sanuki R Miyachi H Miyashita H Taniguchi M Odashima K 《Journal of the American Chemical Society》2004,126(33):10331-10338
A Ni(0)/ZnCl(2) system effectively promotes the coupling of enones and alkene-tethered alkynes. In the reaction with 1,6-enynes, the oxidative cyclization of Ni(0) species on enones across the alkyne part followed by ZnCl(2)-promoted cleavage generates alkenylnickel intermediates. Subsequent migratory insertion of the tethered alkene occurs with 5-exo-cyclization. When the resulting sigma-alkylnickel intermediates have beta-hydrogen atoms, the reaction terminates by beta-hydrogen elimination to provide cyclopentane derivatives. On the other hand, a sigma-alkylnickel intermediate that does not have beta-hydrogen atoms undergoes the insertion of a second alkene unit to cause a domino effect via a three-fold C-C bond formation process with and without the cleavage of one C-C bond. 相似文献
10.
Zegers RG Sumihama M Ahn DS Ahn JK Akimune H Asano Y Chang WC Daté S Ejiri H Fujimura H Fujiwara M Hicks K Hotta T Imai K Ishikawa T Iwata T Kawai H Kim ZY Kino K Kohri H Kumagai N Makino S Matsumura T Matsuoka N Mibe T Miwa K Miyabe M Miyachi Y Morita M Muramatsu N Nakano T Niiyama M Nomachi M Ohashi Y Ooba T Ohkuma H Oshuev DS Rangacharyulu C Sakaguchi A Sasaki T Shagin PM Shiino Y Shimizu H Sugaya Y Toyokawa H Wakai A Wang CW Wang SC Yonehara K Yorita T Yoshimura M Yosoi M 《Physical review letters》2003,91(9):092001
Beam polarization asymmetries for the p(gamma-->,K+)Lambda and p(gamma-->,K+)Sigma(0) reactions are measured for the first time for E(gamma)=1.5-2.4 GeV and 0.6相似文献