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1.
In this paper we give a method for constructing sharply 1-transitive permutation sets inside a finite permutation group with certain properties and we apply this method to obtain a family of sharply 1-transitive permutation subsets of the sharply 3-transitive permutation group M(p
2f
) on PG(1, p
2f
) for p
f
1 (mod 4).Work supported by G.N.S.A.G.A. and M.P.I. 相似文献
2.
Giulia DArrigo Eleonora Gianquinto Giulia Rossetti Gabriele Cruciani Stefano Lorenzetti Francesca Spyrakis 《Molecules (Basel, Switzerland)》2021,26(6)
Flavonoids are plant bioactives that are recognized as hormone-like polyphenols because of their similarity to the endogenous sex steroids 17β-estradiol and testosterone, and to their estrogen- and androgen-like activity. Most efforts to verify flavonoid binding to nuclear receptors (NRs) and explain their action have been focused on ERα, while less attention has been paid to other nuclear and non-nuclear membrane androgen and estrogen receptors. Here, we investigate six flavonoids (apigenin, genistein, luteolin, naringenin, quercetin, and resveratrol) that are widely present in fruits and vegetables, and often used as replacement therapy in menopause. We performed comparative computational docking simulations to predict their capability of binding nuclear receptors ERα, ERβ, ERRβ, ERRγ, androgen receptor (AR), and its variant ART877A and membrane receptors for androgens, i.e., ZIP9, GPRC6A, OXER1, TRPM8, and estrogens, i.e., G Protein-Coupled Estrogen Receptor (GPER). In agreement with data reported in literature, our results suggest that these flavonoids show a relevant degree of complementarity with both estrogen and androgen NR binding sites, likely triggering genomic-mediated effects. It is noteworthy that reliable protein–ligand complexes and estimated interaction energies were also obtained for some suggested estrogen and androgen membrane receptors, indicating that flavonoids could also exert non-genomic actions. Further investigations are needed to clarify flavonoid multiple genomic and non-genomic effects. Caution in their administration could be necessary, until the safe assumption of these natural molecules that are largely present in food is assured. 相似文献
3.
Arrigo Scettri 《Tetrahedron》1985,41(22):5141-5144
4-methoxy-cyclopent-2-en-1-ones are easily obtained through a simple procedure involving in the key-step the conversion of 2-furylcarbinols into 1,1,2-trimethoxy-al-kan-4-ones , a masked form of 1,4-dicarbonyl compounds, by treatment with Amberlyst H15 in methanolic solution. Then, the regeneration of the aldehydic function and a base-catalysed aldolic condensation lead in high yields to the final products . 相似文献
4.
Antonio Massa Laura Capozzolo Arrigo Scettri 《Central European Journal of Chemistry》2010,8(6):1210-1215
SiCl4 can be conveniently activated by catalytic amounts of dimethyl sulfoxide or other readily-available sulfoxides for the allylation
of aromatic, hetero-aromatic and unsaturated aldehydes in the presence of allyltributyl stannane. Chiral aryl methyl sulfoxides
have been used to develop asymmetric allylation methods, as well as probe the aldehyde substrate scope. 相似文献
5.
N.Tz. Dintcheva S. AlessiR. Arrigo G. PrzybytniakG. Spadaro 《Radiation Physics and Chemistry》2012,81(4):432-436
In this paper two systems, polyethylene (LDPE) and polyethylene/commercial organo-modified montmorillonite (LDPE/OMMT) nanocomposite, were subjected to e-beam irradiation at different doses and both the molecular modifications and mechanical properties have been investigated through solubility, FT-IR, calorimetric and tensile tests. Moreover, in some of the irradiated systems photo-oxidation aging was performed and its effects were studied. The results show an enhancement with irradiation of the positive effect of the nano-filler loading, related to the increase of the mechanical properties, due to the increase of the nano-filler polymer interaction.Nevertheless calorimetric and FT-IR data indicate that the well known reduction of LDPE/OMMT nanocomposite resistance to photo-oxidation ageing, with respect to LDPE, is amplified by ionizing radiation. 相似文献
6.
7.
Inga Kwiecie Natalizia Miceli Manuela DArrigo Andreana Marino Halina Ekiert 《Molecules (Basel, Switzerland)》2022,27(3)
Studies carried out using three different in vitro assays and a biological setting (Escherichia coil) demonstrated the antioxidant activity of Scutellaria lateriflora microshoot extract. Moreover, the extract exhibited no toxicity in a brine shrimp lethality bioassay. These results indicated that microshoots are a rich, safe source of antioxidants, which encouraged us to enhance their production in vitro. In agar and agitated cultures, two biotechnological strategies were applied: feeding the cultures with the biogenetic precursors of the phenolics—phenylalanine and tyrosine, and eliciting them with methyl jasmonate. Specific Scutellaria flavonoids and verbascoside were analysed by HPLC. Feeding with precursors (1 g/L) in agar cultures decreased the production of the metabolites. In agitated cultures, different concentrations of precursors (1.0–2.5 g/L) and the elicitor (10; 50; 100 µM) were tested. Additionally, parallel feeding with the precursor and elicitor in a concentration of 50 µM were applied. The best strategy for total flavonoid and verbascoside production was phenylalanine feeding (1.5 g/L), max. 3765 and 475 mg/100 g DW, respectively, after 7 days. This is the first report documenting the high antioxidant production in S. lateriflora microshoots after feeding with phenylalanine. Moreover, for the first time, bioreactor cultures were successfully maintained, obtaining attractive results (max. total flavonoid content 2348 and verbascoside 485 mg/100 g DW). 相似文献
8.
Arrigo Bonisoli 《Journal of Geometry》1988,31(1-2):32-41
If p is an odd prime and R is a sharply 1-transitive subset of PGL(2,pm) which contains the identity but is not a group, then the subgroup generated by R is either PSL(2,pm) or PGL(2,pm).work done within the activity of G.N.S.A.G.A. and supported by the Italian Ministry of Public EducationDedicated to Professor Helmut Karzel on his 60th birthday 相似文献
9.
Let be a 2‐factorization of the complete graph Kv admitting an automorphism group G acting doubly transitively on the set of vertices. The vertex‐set V(Kv) can then be identified with the point‐set of AG(n, p) and each 2‐factor of is the union of p‐cycles which are obtained from a parallel class of lines of AG(n, p) in a suitable manner, the group G being a subgroup of A G L(n, p) in this case. The proof relies on the classification of 2‐(v, k, 1) designs admitting a doubly transitive automorphism group. The same conclusion holds even if G is only assumed to act doubly homogeneously. © 2006 Wiley Periodicals, Inc. J Combin Designs 相似文献
10.
Starting from a linear collineation of PG(2n–1,q) suitably constructed from a Singer cycle of GL(n,q), we prove the existence of a partition of PG(2n–1,q) consisting of two (n–1)-subspaces and caps, all having size (qn–1)/(q–1) or (qn–1)/(q+1) according as n is odd or even respectively. Similar partitions of quadrics or hermitian varieties into two maximal totally isotropic subspaces and caps of equal size are also obtained. We finally consider the possibility of partitioning the Segre variety
of PG(8,q) into caps of size q2+q+1 which are Veronese surfaces. 相似文献