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A stereoselective approach for the total synthesis of lactone (5R,7R,9R)-7,9-dihydroxy-5-decanolide is described. The sequence of synthetic reactions involves a Keck asymmetric allylation, diastereoselective iodo-carbonate cyclization, regioselective ring-opening reaction, oxidative lactonization. 相似文献
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Varma Nimmu Narendra Naidu Challa Gangu Ramachandra Bondigalla Swamy Arnipalli Manikanta 《Journal of Analytical Chemistry》2021,76(10):1172-1181
Journal of Analytical Chemistry - A water-compatible molecularly imprinted polymer (MIP) was prepared for specific extraction of HIV-1 integrase inhibitor elvitegravir (EVG). It was prepared by a... 相似文献
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Mopuri Sudhakar Reddy Gembali Manikanta Palakodety Radha Krishna 《Tetrahedron letters》2019,60(6):504-506
The first stereoselective total synthesis of antibiotic macrolide Berkeleylactone F is described. The synthetic sequence notably features Sharpless kinetic resolution to access chiral epoxide followed by its regioselective ring-opening reaction, Sharpless asymmetric reaction and ring-closing metathesis. 相似文献
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Dried blood spot analysis of (+) and (−) darunavir enantiomers on immobilized amylose tris‐(3, 5‐dimethylphenylcarbamate) LC and its application to pharmacokinetics 下载免费PDF全文
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Turan Nevin Buldurun Kenan Türkan Fikret Aras Abdulmelik Çolak Naki Murahari Manikanta Bursal Ercan Mantarcı Asim 《Molecular diversity》2022,26(5):2459-2472
Molecular Diversity - Schiff bases are well-known compounds for having significant biological properties. In this study, a new Schiff base ligand and its metal complexes were synthesized, and their... 相似文献
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Narendra Varma Nimmu M. K. Swamy Arnipalli Keerthi Appu Sara Khalid Nageswara Rao Ramisetti 《Chromatographia》2018,81(11):1551-1557
A sensitive, rapid and reproducible LC–MS/MS method for the determination of olmesartan (OLM), amlodipine (ALM) and hydrochlorothiazide (HCZ) in rat plasma and urine has been developed and validated. Irbesartan (IRB) was used as an internal standard. The analytes were separated on a Waters XTerra-C18 column using gradient elution with acetonitrile and 10 mM ammonium acetate buffer (pH 3.5, adjusted with acetic acid) at a flow rate of 1.0 mL min?1. The three analytes were ionized by positive ion electrospray using multiple-reaction monitoring (MRM) mode to monitor precursor?→?product ion transitions m/z 447.31?→?234.97 for OLM, 408.87?→?238.18 for AML and 290.1?→?204.85 for HCZ. The specificity, matrix effect, recovery, sensitivity, linearity, accuracy, precision, and stabilities were all validated over the concentration range 0.4–100 ng mL?1 for AML, 0.2–100 ng mL?1 for OLM, 0.1–100 ng mL?1 for HCZ. The mean concentrations (Cmax) are 10.32, 587, and 3.4 for OLM, ALM, and HCZ, respectively, by the oral administration of 15 mg kg?1 of each analyte. 相似文献
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Neha Srivastava Manish Srivastava Ambepu Manikanta Pardeep Singh P.W. Ramteke P.K. Mishra Bansi D Malhotra 《Applied biochemistry and biotechnology》2017,183(2):601-612
Cellulase enzymes have versatile industrial applications. This study was directed towards the isolation, production, and characterization of cellulase enzyme system. Among the five isolated fungal cultures, Emericella variecolor NS3 showed maximum cellulase production using untreated orange peel waste as substrate using solid-state fermentation (SSF). Maximum enzyme production of 31 IU/gds (per gram of dry substrate) was noticed at 6.0 g concentration of orange peel. Further, 50 °C was recorded as the optimum temperature for cellulase activity and the thermal stability for 240 min was observed at this temperature. In addition, the crude enzyme was stable at pH 5.0 and held its complete relative activity in presence of Mn2+ and Fe3+. This study explored the production of crude enzyme system using biological waste with future potential for research and industrial applications. 相似文献
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This paper describes two simple, specific, accurate, and precise methods for estimation of olopatadine hydrochloride (OLO) in tablet dosage form. The first method is a stability-indicating isocratic RP-HPLC method. The analysis is performed on an RP-18 column using 0.1% orthophosphoric acid (adjusted to pH 4.5 with triethylamine)-acetonitrile (75 + 25, v/v) mobile phase at a flow rate of 1 mL/min. Paracetamol (PAR) was selected as the internal standard. Retention times of OLO and PAR were 11.30 +/- 0.02 and 4.70 +/- 0.03 min, respectively. For the HPTLC method, precoated silica gel 60 F254 aluminum sheets were used as the stationary phase; the mobile phase was methanol-chloroform-ammonia (8 + 2 + 0.1, v/v/v). The detection of the analyte band was carried out at 301 nm, and its Rf value was 0.46 +/- 0.03. The analytical methods were validated according to International Conference on Harmonization guidelines. Linear regression analysis data for the calibration plots showed a good linear relationship between response and concentration in the range of 0.1-1 microg/mL and 0.1-0.9 microg/band for HPLC and HPTLC, respectively. 相似文献
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