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1.
Gregorio Snchez Francisco Ruiz Joaquín Garcia M. Ramírez Carmen de Arellano Gregorio Lpez 《Helvetica chimica acta》1997,80(8):2477-2485
The hydroxo complex (Bu4N)2[Ni2(C6F5)4(μ-OH)2]reacts with 2,3,4,5,6-pentafluoro benzenamine (C6F5-NH2), 1,3-diaryltriaz-1-enes (ArNH? N=N? Ar, Ar = Ph, 4-MeC6H4, 4-MeOC6H4), 7-aza-1H-indole (= 1H-pyrrolo[2.3-b]pyridine; Hazind), N-phenylpyridin-2-amine(pyNHPh), and N-phenylpyridine-2-carboxamide (py-CONHPh) at room temperature in acetone to give the binuclear complexes (Bu4N)2[Ni2(C6F5)4(μ-C6F5NH)2] ( 1 ) and (Bu4N)2[{Ni(C6F5)2} 2(μ-OH)(μ-azind)] ( 2 ) and the mononuclear complexes Bu4N[Ni(C6F5)2(ArN3Ar)] ( 3 – 5 ), Bu4N[Ni(C6F5)2(pyNPh)] ( 6 ), and Bu4N[Ni(C6F5)2(pyCONPh)] ( 7 ). The hydroxo.complex (Bu4N)2[{Ni(C6F5)2-(μ-OH)}2] promotes the nucleophilic addition of water to pyridine-2-carbonitrile, 2-aminoacetonitrile, and 2-(dimethylamino)acetonitrile, and complexes 8 – 10 containing pyridine-2-carboxamidato, 2-aminoacetamidato and 2-(dimethylamino)acetamidato ligands are formed. Analytical (C, H, N) and spectroscopic (IR, 1H and 19F-NMR, and FAB-MS) data were used for structural assignments. A single-crystal X-ray diffraction study of (Bu4N)2[{Ni(C6F5)2}2(μ-OH)(μ-azind)] ( 2 ) established the binuclear nature of the anion; the two Ni-atoms are bridged by an OH group and a 7-aza-7H-indol-7-yl group, but the central Ni? O? Ni? N? C? N ring is not planar, the dihedral angle between the Ni? O? Ni and Ni? N? C? N? Ni planes being 84.4°. 相似文献
2.
Volonterio A Bellosta S Bravin F Bellucci MC Bruché L Colombo G Malpezzi L Mazzini S Meille SV Meli M Ramírez De Arellano C Zanda M 《Chemistry (Weinheim an der Bergstrasse, Germany)》2003,9(18):4510-4522
Partially modified retro- (PMR) and retro-inverso (PMRI) psi[NHCH(CF(3))]Gly peptides, a conceptually new class of peptidomimetics, have been synthesized in wide structural diversity and variable length by aza-Michael reaction of enantiomerically pure alpha-amino esters and peptides with enantiomerically and geometrically pure N-4,4,4-trifluorocrotonoyl-oxazolidin-2-ones. The factors underlying the observed moderate to good diastereocontrol have been investigated. The conformations of model PMR-psi[NHCH(CF(3))]Gly tripeptides have been studied in solution by (1)H NMR spectroscopy supported by MD calculations, as well as in the solid-state by X-ray diffraction. Remarkable stability of turn-like conformations, comparable to that of parent malonyl-based retropeptides, was evidenced, as a likely consequence of two main factors: 1) severe torsional restrictions about sp(3) bonds in the [CO-CH(2)-CH(CF(3))-NH-CH(R)-CO] module, which is biased by the stereoelectronically demanding CF(3) group and the R side chain; 2) formation of nine-membered intramolecularly hydrogen-bonded rings, which have been clearly detected both in CHCl(3) solution and in some crystal structures. The former factor seems to be more important, as turn-like conformations were found in the solid-state even in the absence of intramolecular hydrogen bonding. The relative configuration of the -C*H(CF(3))NHC*H(R)- stereogenic centers has a major effect on the stability of the turn-like conformation, which seems to require a syn stereochemistry. X-ray diffraction and ab initio computational studies showed that the [-CH(CF(3))NH-] group can be seen as a sort of hybrid between a peptide bond mimic and a proteolytic transition state analogue, as it combines some of the properties of a peptidyl -CONH- group (low NH basicity, CH(CF(3))-NH-CH backbone angle close to 120 degrees, C-CF(3) bond substantially isopolar with the C=O) with some others of the tetrahedral intermediate [-C(OX)(O(-))NH-] involved in the protease-mediated hydrolysis reaction of a peptide bond (high electron density on the CF(3) group, tetrahedral backbone carbon). 相似文献
3.
F. Arellano I. García-Sosa M. Solache-Ríos 《Journal of Radioanalytical and Nuclear Chemistry》1995,199(2):107-113
The sorption behavior of cobalt and cadmium by zeolite Y has been investigated. Cobalt and cadmium solutions were exchanged with the zeolite at different pH's. Cobalt, cadmium and sodium in the samples were determined by neutron activation analysis. The sorption of cadmium was higher than that of cobalt, however, the selectivity for both cations by the zeolite was low. 相似文献
4.
A. M. A. P. Fernandes G. D. Fernandes D. Barrera‐Arellano G. F. de Sá R. D. Lins M. N. Eberlin R. M. Alberici 《Journal of mass spectrometry : JMS》2014,49(5):ii-ii
Knowledge of the major effects governing desorption/ionization efficiency is required for the development and application of ambient mass spectrometry. Although all triacylglycerols (TAG) have the same favorable protonation and cationization sites, their desorption/ionization efficiencies can vary dramatically during easy ambient sonic‐spray ionization because of structural differences in the carbon chain. To quantify this somewhat surprising and drastic effect, we have performed a systematic investigation of desorption/ionization efficiencies as a function of unsaturation and length for TAG as well as for diacylglycerols, monoacylglycerols and several phospholipids (PL). Affinities for Na+ as a function of unsaturation level have also been assayed via comprehensive metadynamics calculations to understand the influence of this phenomenon on the ionization efficiency. The results suggest that dipole–dipole interactions within a carbon chain tuned by unsaturation sites govern ionization efficiency of TAG and PL. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
5.
Combinatorially Designed Lipid‐like Nanoparticles for Intracellular Delivery of Cytotoxic Protein for Cancer Therapy 下载免费PDF全文
Dr. Ming Wang Kyle Alberti Shuo Sun Carlos Luis Arellano Prof. Dr. Qiaobing Xu 《Angewandte Chemie (International ed. in English)》2014,53(11):2893-2898
An efficient and safe method to deliver active proteins into the cytosol of targeted cells is highly desirable to advance protein‐based therapeutics. A novel protein delivery platform has been created by combinatorial design of cationic lipid‐like materials (termed “lipidoids”), coupled with a reversible chemical protein engineering approach. Using ribonuclease A (RNase A) and saporin as two representative cytotoxic proteins, the combinatorial lipidoids efficiently deliver proteins into cancer cells and inhibit cell proliferation. A study of the structure–function relationship reveals that the electrostatic and hydrophobic interactions between the lipidoids and the protein play a vital role in the formation of protein–lipidoid nanocomplexes and intracellular delivery. A representative lipidoid (EC16‐1) protein nanoparticle formulation inhibits cell proliferation in vitro and suppresses tumor growth in a murine breast cancer model. 相似文献
6.
J.?Ramírez?OrtegaEmail author N.?L.?Vasilevski E.?Ramírez?de?Arellano 《Integral Equations and Operator Theory》2003,46(4):455-471
Let be a domain with smooth boundary and let α be a C
2-
diffeomorphism on satisfying the Carleman condition .We denote
by the C*-algebra generated by the Bergman projection of G, all multiplication
operators aI and the operator where is the Jacobian of α. A symbol algebra of is determined and Fredholm
conditions are given. We prove that the C*-algebra generated by the Bergman
projection of the upper half-plane and the operator is isomorphic
and isometric to .
Submitted: February 11, 2001?Revised: January 27, 2002 相似文献
7.
The exchange of chemical species between the atmospheric boundary layer and the reservoir layer is investigated by means of an analytical solution of the conservation equation of a decaying chemical species. The exchange mechanism is governed by two parameters: the Damköhler number (the ratio of the turbulence time scale to the chemical time scale) and the ratio of a concentration scale in the atmospheric boundary layer to the concentration in the reservoir layer. Depending on the value of these two parameters, the exchange flux between the two layers can vary in sign and by several orders of magnitude. The study demonstrates to what extent chemical transformation determines the transfer of chemical species between the atmospheric boundary layer and the reservoir layer. 相似文献
8.
Ramírez-López P de la Torre MC Asenjo M Ramírez-Castellanos J González-Calbet JM Rodríguez-Gimeno A de Arellano CR Sierra MA 《Chemical communications (Cambridge, England)》2011,47(37):10281-10283
Reported herein is the discovery of a novel family of "clicked" estradiol-based LMWGs whose gelation ability highly depends on the gelator symmetry. These LMWGs that gel different organic solvents in the presence of H(2)O even at concentrations as low as 0.04 wt% are readily accessible using "click" chemistry. 相似文献
9.
Juan B. Arellano B. Bangar Raju† K. Razi Naqvi Tomas Gillbro‡ 《Photochemistry and photobiology》1998,68(1):84-87
Abstract— In this short communication we present the stoichiometric ratio of bacteriochlorophyll, bacteriopheophytin and carotenoids in a few photosynthetic purple bacteria complexes (whose two-dimensional or three-dimensional structures are well known) determined using the spectrum-reconstruction method (SRCM). An important conclusion of our pigment stoichiometric analysis is the evidence for the absence of the second carotenoid in the light-harvesting complex 2 (LH2). In the process, we also highlight the useful application of SRCM in determining the molar extinction coefficients of carotenoids present in LH1, LH2 or reaction centers for which these values are not known due to isolation problems and/or stability. 相似文献
10.
Jiang W Chen C Marinkovic D Tran JA Chen CW Arellano LM White NS Tucci FC 《The Journal of organic chemistry》2005,70(22):8924-8931
[reaction: see text] 2-[4-(tert-Butoxycarbonyl)piperazinyl]benzylidene-tert-butanesulfinamides underwent nucleophilic 1,2-addition with different organometallic reagents to give highly diastereomerically enriched adducts. X-ray crystallography of the resulting alpha-branched N-Boc-2-piperazinylbenzyl-tert-butanesulfinamides confirms different mechanisms depending on the organometallic reagent used. Differential deprotection of the N-Boc and the tert-butanesulfinamides was investigated, and the dehydration byproducts have been identified and characterized. To avoid the formation of byproducts in the acidic deprotection step, the N-tert-butanesulfinamide group was converted to the corresponding N-tert-butanesulfonamide (Bus), which allowed for clean orthogonal deprotection. The efficient synthesis and deprotection of the N-Boc-2-piperazinylbenzyl-tert-butanesulfinamides herein described constitutes an attractive method for extensive structure-activity studies in the search for novel ligands of the human melanocortin 4 receptor. 相似文献