Radical-mediated intramolecular C-C bond formation and the deoxygenation of alcohols under solvent-free conditions with tributyl methyl ammonium hypophosphite

A green, solvent-free protocol was developed for the radical-mediated intramolecular cyclization of haloacetals and the deoxygenation of S-methyl dithiocarbonates and cyclic thionocarbonate. This process uses tributyl methyl ammonium hypophosphite as a H-donor in the presence of triethylborane or t-butyl peroxide. This methodology provides eco-friendly reaction conditions.     

Potassium Dodecatungsto Cobaltate Trihydrate: A New Heterogeneous Catalyst for the Synthesis of Homoallylic Alcohols and Amines

A simple and efficient procedure has been developed for one-pot synthesis of homoallylic alcohols and amines in good to excellent yields using a variety of aldehydes, amines, and allyltributylstannane in the presence of a catalytic amount of potassium dodecatungsto cobaltate trihydrate (K₅CoW₁₂O₄₀ · 3H₂O) as a heterogeneous catalyst at room temperature. The catalyst exhibited remarkable reusability.     

An azo dye-coupled tripodal chromogenic sensor for cyanide

A tripodal receptor bearing phenol as a hydrogen bond donor site and azo dye as the signaling subunit was synthesized. The receptor had a high binding affinity for CN⁻ as signaled by the change in the color of a solution of sensor 4 upon addition of CN⁻. Using UV-Vis spectroscopy, the system can be used to quantify 0-19 × 10⁻⁵ mol L⁻¹ of CN⁻, and the sensor was found to successfully function in the presence of other anions.     

Total synthesis of (+)-varitriol via a symmetrical furanose diol as the key intermediate

Alternative, simple and efficient route for (+)-varitriol (1), a marine-derived natural product with potent biological activity, has been synthesized from d-ribose. In this synthetic strategy symmetrical diol (6) with mono alcohol protection, the key intermediate, was produced in eight steps with 35% overall yield and the significance of 6 as the key furanoside building block for the synthesis of novel analogues of 1 for SAR studies was explained.