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V. Tassetti A. Hajri M. Sowinska S. Evrard F. Heisel L. Q. Cheng J. A. Miehe J. Marescaux M. Aprahamian 《Photochemistry and photobiology》1997,65(6):997-1006
Laser-induced fluorescence (LIF) of pheophorbide-a (Ph-a) was used for imaging of a rat pancreatic tumor. Using a dimensionless function (the ratio of Ph-a fluorescence by bluish autofluorescence), the fluorescence contrasts between excised tumors and their paired pancreas were investigated up to 48 h after a 9 mg kg-1 Ph-a intravenous administration. Among five tested excitation wavelengths, 355 and 610 nm excitations gave the best distinctive contrasts, both 48 h after dye injection. The LIF imaging of six intrapancreatic tumors and six healthy pancreas was carried out in vivo using two laser excitations: 355 nm (Nd:YAG + tripling) for bluish autofluorescence and 610 nm (rhodamine 6G dye) for reddish autofluorescence and dye emission. Images were recorded through bandpass filters at 470 and 640 nm (autofluorescence) and at 680 nm (dye + autofluorescence) with an intensified charged-coupled device camera. Autofluorescence as Ph-a fluorescence images did not allow accurate LIF diagnosis of pancreatic carcinoma. An image processing, including for each pixel a computed division of Ph-a fluorescence (after subtraction of reddish autofluorescence) by bluish autofluorescence intensity generated poorly contrasted tumor images in five of six and false tumor localization in one of three of the tumor-bearing pancreas. A fitting of the digital 640 nm autofluorescence up to the mean 680 nm fluorescence intensity in pancreas prior to subtraction allowed a safe diagnosis to be made with well-contrasted tumor images. To assess automation ability of the processing, a same fitting coefficient (mean of individual values) was applied. In this way, false-negative (one of six) and false-positive (two of six) images were present in tumor-bearing animals as false-positive in one-half of the controls. A successful standardized procedure was then applied with a normalization of 640 and 680 nm pancreas intensities to a same set threshold prior processing. In opposition to thin-layered hollow organs, such as bronchial tube or digestive tract, LIF imaging of carcinoma inserted in a compact organ is exhausting. The use of a dye excitable in the red wavelength range (610 nm for Ph-a) may partly solve this problem, rendering LIF imaging more accurate and potentially automated. 相似文献
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Grace C. Thaggard Dr. Gabrielle A. Leith Daniil Sosnin Dr. Corey R. Martin Kyoung Chul Park Margaret K. McBride Dr. Jaewoong Lim Brandon J. Yarbrough Buddhima K. P. Maldeni Kankanamalage Gina R. Wilson Austin R. Hill Dr. Mark D. Smith Prof. Dr. Sophya Garashchuk Prof. Dr. Andrew B. Greytak Prof. Dr. Ivan Aprahamian Prof. Dr. Natalia B. Shustova 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2023,135(2):e202211776
Confinement-imposed photophysics was probed for novel stimuli-responsive hydrazone-based compounds demonstrating a conceptual difference in their behavior within 2D versus 3D porous matrices for the first time. The challenges associated with photoswitch isomerization arising from host interactions with photochromic compounds in 2D scaffolds could be overcome in 3D materials. Solution-like photoisomerization rate constants were realized for sterically demanding hydrazone derivatives in the solid state through their coordinative immobilization in 3D scaffolds. According to steady-state and time-resolved photophysical measurements and theoretical modeling, this approach provides access to hydrazone-based materials with fast photoisomerization kinetics in the solid state. Fast isomerization of integrated hydrazone derivatives allows for probing and tailoring resonance energy transfer (ET) processes as a function of excitation wavelength, providing a novel pathway for ET modulation. 相似文献
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[reaction: see text] A guest molecule-a bis-N-tetraethyleneglycol-substituted 3,3'-difluorobenzidine derivative-has been synthesized, and its complexation with the host, cyclobis(paraquat-p-phenylene), has been investigated. This host-guest complex was then employed in the template-directed synthesis of a blue-colored [2]rotaxane. The color of this [2]rotaxane arises from the charge-transfer absorption band between the HOMO of the guest and the LUMO of the host. This host-guest complex, and the derived [2]rotaxane, completes the donor-acceptor-based RGB (red/green/blue) color complex set. 相似文献
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K. H. Maier A. Aprahamian J. A. Becker D. J. Decman E. A. Henry R. G. Lanier L. G. Mann R. A. Meyer K. Sale N. Roy W. Stöffl G. L. Struble J. Blomqvist 《Zeitschrift für Physik A Hadrons and Nuclei》1989,332(3):263-268
Gamma rays and conversion electrons have been measured in211Bi populated by the209Bi(t,p) reaction, and the near yrast levels were observed up to 21/2?. The 21/2? state is isomeric withT 1/2=70(5) ns. No alpha decaying isomer was found in211Bi. ObservedM1 transitions reveal mixing of the210Pb parent states in the levels of211Bi. The levels and transitions are well reproduced by the shell model with experimental matrix elements and pure configurations. 相似文献
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B. B. Skorodumov G. V. Rogachev P. Boutachkov A. Aprahamian J. J. Kolata L. O. Lamm M. Quinn A. Woehr 《Physics of Atomic Nuclei》2006,69(12):1979-1984
The structure of the unbound proton-rich isotope 19Na was studied in resonance elastic scattering of a radioactive 18Ne beam on a proton target using the thick-target inverse-kinematics method. The experiment covered the excitation energy
range from 0.5 to 2.7 MeV in c.m.s. Only one state of 19Na (the second excited state) was observed. A combined R-matrix and potential model analysis was performed. The spin and parity assignment of this second excited state was confirmed
to be 1/2+. We show that the position of the 1/2+ state significantly affects the reaction rate through that state, but the total reaction rate remains unchanged since the
18Ne(2p, γ) proceeds mostly via the ground and first excited states in 19Na at stellar temperatures.
The text was submitted by the authors in English. 相似文献
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Decreasing and fast solutions for a second-order difference equation related to Fisher-Kolmogorov's equation 总被引:1,自引:0,他引:1
Meline Aprahamian Stepan Tersian 《Journal of Mathematical Analysis and Applications》2010,363(1):97-110
We prove the existence of so-called fast solutions of a second-order difference equation related to traveling wave solutions of Fisher-Kolmogorov's equation. Variational approach is used and the fast solutions are obtained as minimizers of an energy functional on a weighted Hilbert space. Numerical experiments are presented. 相似文献