Transition‐metal‐free N‐arylation: A general approach to aza‐fused poly‐heteroaromatics

A new and efficient method for the synthesis of various aza‐fused poly‐hetero aromatics has been described. This protocol includes an intermolecular condensation followed by metal‐free base‐promoted intramolecular C―N coupling reaction. The advantage of this one‐pot transformation lies in the use of simple cyclic amidines‐like compounds without prefunctionalization of the starting heterocycles.     

Synthesis of Novel Amide-Functionalized Imidazo[1,2-a]pyrimidin-5(1H)-ones and Their Biological Evaluation as Anticancer Agents

Russian Journal of Organic Chemistry - A series of novel amide-functionalized imidazo[1,2-a]pyrimidin-5(1H)-ones were synthesized by propargylation of the key intermediate...