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Nataliya A. Sanina Arina A. Starostina Andrey N. Utenyshev Pavel V. Dorovatovskii Nina S. Emelyanova Vladimir B. Krapivin Victor B. Luzhkov Viktoriya A. Mumyatova Anastasiya A. Balakina Alexei A. Terentiev Sergey M. Aldoshin 《Molecules (Basel, Switzerland)》2022,27(20)
In this work a new donor of nitric oxide (NO) with antibacterial properties, namely nitrosyl iron complex of [Fe(C6H5C-SNH2)2(NO)2][Fe(C6H5C-SNH2)(S2O3)(NO)2] composition (complex I), has been synthesized and studied. Complex I was produced by the reduction of the aqueous solution of [Fe2(S2O3)2(NO)2]2− dianion by the thiosulfate, with the further treatment of the mixture by the acidified alcohol solution of thiobenzamide. Based on the structural study of I (X-ray analysis, quantum chemical calculations by NBO and QTAIM methods in the frame of DFT), the data were obtained on the presence of the NO…NO interactions, which stabilize the DNIC dimer in the solid phase. The conformation properties, electronic structure and free energies of complex I hydration were studied using B3LYP functional and the set of 6–31 + G(d,p) basis functions. The effect of an aquatic surrounding was taken into account in the frame of a polarized continuous model (PCM). The NO-donating activity of complex I was studied by the amperometry method using an “amiNO-700” sensor electrode of the “inNO Nitric Oxide Measuring System”. The antibacterial activity of I was studied on gram-negative (Escherichia coli) and gram-positive (Micrococcus luteus) bacteria. Cytotoxicity was studied using Vero cells. Complex I was found to exhibit antibacterial activity comparable to that of antibiotics, and moderate toxicity to Vero cells. 相似文献
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Konstantin V. Lipin Mikhail Yu. Ievlev Anastasiya I. Ershova Oleg V. Ershov 《Molecules (Basel, Switzerland)》2022,27(21)
New representatives of 2-(butylamino)cinchomeronic dinitrile derivatives were synthesized as promising fluorophores showing dual-state emission. To characterize the influence of the length (from methyl to butyl) and the structure (both linear and branched) of the alkyl substituent at the amino nitrogen atom, the spectral fluorescence properties of all synthesized compounds were carefully studied both in solution and in solid state. The highest photoluminescence quantum yield values of 63% were noted for solutions of 2-(butylamino)-6-phenylpyridine-3,4-dicarbonitrile in DCM and 2-(butylamino)-5-methyl-6-phenylpyridine-3,4-dicarbonitrile in toluene. 相似文献
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Victor V. Dotsenko Arif I. Ismiev Anastasiya N. Khrustaleva Konstantin A. Frolov Sergey G. Krivokolysko Elena A. Chigorina Aleksey P. Snizhko Vladimir M. Gromenko Ivan S. Bushmarinov Rizvan K. Askerov Tatyana M. Pekhtereva Sergey Yu. Suykov Elena S. Papayanina Aleksandr V. Mazepa Abel M. Magerramov 《Chemistry of Heterocyclic Compounds》2016,52(7):473-483
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Krivdin LB Khutsishvili SS Shemyakina OA Mal'kina AG Trofimov BA Contreras RH 《Magnetic resonance in chemistry : MRC》2007,45(9):758-765
Configurational assignment and conformational analysis of a series of iminodihydrofurans obtained from cyanoacetylenic alcohols were performed on the basis of experimental measurements and high-level ab initio calculations of their (13)C-(13)C spin-spin coupling constants. The title compounds were shown to form and exist in solution as the individual Z isomers, adopting the orthogonal orientation of the amino, alkylamino and dialkylamino groups and the s-trans orientation of the CONH(2) group at the C(4) position of the 2,5-dihydro-2-iminofuran moiety. 相似文献
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EV Tretyakov SE Tolstikov AO Suvorova AV Polushkin GV Romanenko AS Bogomyakov SL Veber MV Fedin DV Stass E Reijerse W Lubitz EM Zueva VI Ovcharenko 《Inorganic chemistry》2012,51(17):9385-9394
Breathing crystals based on polymer-chain complexes of Cu(hfac)(2) with nitroxides exhibit thermally and light-induced magnetostructural anomalies in many aspects similar to a spin crossover. In the present work, we report the synthesis and investigation of a new family of Cu(hfac)(2) complexes with tert-butylpyrazolylnitroxides and their nonradical structural analogues. The complexes with paramagnetic ligands clearly exhibit structural rearrangements in the copper(II) coordination units and accompanying magnetic phenomena characteristic for breathing crystals. Contrary to that, their structural analogues with diamagnetic ligands do not undergo rearrangements in the copper(II) coordination environments. This confirms experimentally the crucial role of paramagnetic ligands and exchange interactions between them and copper(II) ions for the origin of magnetostructural anomalies in this family of molecular magnets. 相似文献
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Ivan N. Bardasov Anastasiya U. Alekseeva Denis L. Mihailov Oleg V. Ershov Oleg E. Nasakin Viktor A. Tafeenko 《Tetrahedron letters》2014
The synthesis of 2-(dicyanomethylene)-1,2-dihydropyridine derivatives from the reactions of arylmethylidene derivatives of malononitrile dimers with 1,3-dicarbonyl compounds is described. 相似文献
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Anastasiya V. Igushkina Alexander A. Golovanov Irina A. Boyarskaya Ilya E. Kolesnikov Aleksander V. Vasilyev 《Molecules (Basel, Switzerland)》2020,25(24)
Reaction of linear conjugated enynones, 1,5-diarylpent-2-en-4-yn-1-ones, with malononitrile in the presence of lithium diisopropylamide LDA, as a base, in THF at room temperature for 3–7 h resulted in the formation of the product of dimerization, multisubstituted polyfunctional cyclohexanes, 4-aryl-2,6-bis(arylethynyl)-3-(aryloxomethyl)-4-hydroxycyclohexane-1,1-dicarbonitriles, in yields up to 60%. Varying the reaction conditions by decreasing time and temperature and changing the ratio of starting compounds (enynone and malononitrile) allowed isolating some intermediate compounds, which confirmed a plausible reaction mechanism. The relative stability of possible stereoisomers of such cyclohexanes was estimated by quantum chemical calculations (DFT method). The obtained cyclohexanes were found to possess photoluminescent properties. 相似文献
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Grigor’ev Arthur A. Kayukov Yakov S. Nikiforova Anastasiya L. Karpov Sergey V. Shchegravina Ekaterina S. Kayukova Olga V. Tafeenko Victor A. 《Chemistry of Heterocyclic Compounds》2019,55(2):167-171
Chemistry of Heterocyclic Compounds - 4-Acyl-2-amino-6-chloropyridine-3,5-dicarbonitriles underwent heterocyclization in the presence of ammonia in aqueous dioxane medium, involving the... 相似文献