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1.
Sudipta Jena Asit Ray Omprakash Mohanta Prabhat Kumar Das Ambika Sahoo Sanghamitra Nayak Pratap Chandra Panda 《Molecules (Basel, Switzerland)》2022,27(23)
Neocinnamomum caudatum (Lauraceae) plant is used in the traditional system of medicine and is considered a potential source of edible fruits, spices, flavoring agents and biodiesel. The leaves, bark and roots of the species are used by local communities for the treatment of inflammatory responses, such as allergies, sinusitis and urinary tract infections. However, there is no scientific evidence to support the molecular mechanism through which this plant exerts its anti-inflammatory effect. The aim of the current research was to characterize the chemical constituents of bark (NCB) and leaf (NCL) essential oil of N. caudatum and to elucidate its anti-inflammatory action in lipopolysaccharide (LPS)-treated RAW 264.7 cells. Essential oils extracted by hydrodistillation were further subjected to gas chromatography mass spectrometry (GC-MS) analysis. The major constituents in bark essential oil identified as β-pinene (13.11%), α-cadinol (11.18%) and α-pinene (10.99%), whereas leaf essential oil was found to be rich in β-pinene (45.21%), myrcene (9.97%) and α-pinene (9.27%). Treatment with NCB and NCL at a concentration of 25 µg/mL exerted significant anti-inflammatory activity by significantly reducing LPS-triggered nitric oxide (NO) production to 45.86% and 61.64%, respectively, compared to the LPS-treated group. In the LPS-treated group, the production of proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β, decreased after treatment with essential oil, alleviating the mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2. The essential oil also inhibited the production of intracellular ROS and attenuated the depletion of mitochondrial membrane potential in a concentration-dependent manner. Pretreatment with NCB also reduced nuclear factor kappa-B (NF-κB)/p65 translocation and elevated the levels of endogenous antioxidant enzymes in LPS-induced macrophages. The present findings, for the first time, demonstrate the anti-inflammatory potential of both bark and leaf essential oils of N. caudatum. The bark essential oil exhibited a significantly more important anti-inflammatory effect than the leaf essential oil and could be used as a potential therapeutic agent for the treatment of inflammatory diseases. 相似文献
2.
Madhusoodanan Nima Ambika Lalan Vidhya Ganesanpotti Subodh 《Journal of fluorescence》2021,31(5):1323-1332
Journal of Fluorescence - A facile and green strategy was carried out for the preparation of fluorescent carbon nanoparticles (CNp) using non-toxic circassian seeds as carbon precursor (CNp, named... 相似文献
3.
Atul Asati Santimukul Santra Dr. Charalambos Kaittanis Sudip Nath Dr. J. Manuel Perez Prof. 《Angewandte Chemie (International ed. in English)》2009,48(13):2308-2312
Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase‐like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).
4.
Jena Sudipta Ray Asit Sahoo Ambika Kamila Pradeep Kumar Nayak Sanghamitra Panda Pratap Chandra 《Chemistry of Natural Compounds》2021,57(6):1147-1149
Chemistry of Natural Compounds - 相似文献
5.
Chemoselective esterification of phenolic acids with dialkyl sulphates or alkyl halides in the presence of sodium bicarbonate in 1,3‐dialkylimidazolium ionic liquids is reported in excellent yields and less reaction time as compared to organic solvents. 相似文献
6.
We present a graphical analysis of the mechanisms underlying the occurrences of bubbling sequences and bistability regions
in the bifurcation scenario of a special class of one dimensional two parameter maps. The main result of the analysis is that
whether it is bubbling or bistability is decided by the sign of the third derivative at the inflection point of the map function. 相似文献
7.
This paper is a review of the present status of studies relating to occurrence of deterministic chaos and its characterization
in one-dimensional maps. As our primary aim is to introduce the nonspecialists into this fascinating world of chaos we start
from very elementary concepts and give sufficient arguments for clarity of ideas. The two main scenarios during onset of chaos
viz. the period doubling and intermittency are dealt with in detail. Although the logistic map is often discussed by way of
illustration, a few more interesting maps are mentioned towards the end. 相似文献
8.
Dynamical systems with nonlinear damping show interesting behavior in the periodic and chaotic phases. The Froude pendulum
with cubical and linear damping is a paradigm for such a system. In this work the driven Froude pendulum is studied by the
harmonic balancing method; the resulting nonlinear response curves are studied further for resonance and stability of symmetric
oscillations with relatively low damping. The stability analysis is carried out by transforming the system of equations to
the linear Mathieu equation. 相似文献
9.
K.P.?HarikrishnanEmail author R.?Misra G.?Ambika 《The European Physical Journal B - Condensed Matter and Complex Systems》2013,86(9):394
Using a recently proposed algorithmic scheme for correlation dimension analysis of hyperchaotic attractors, we study two well-known hyperchaotic flows and two standard time delayed hyperchaotic systems in detail numerically. We show that at the transition to hyperchaos, the nature of the scaling region changes suddenly and the attractor displays two scaling regions for embedding dimension M ≥ 4. We argue that it is an indication of a strong clustering tendency of the underlying attractor in the hyperchaotic phase. Because of this sudden qualitative change in the scaling region, the transition to hyperchaos can be easily identified using the discontinuous changes in the dimension (D 2) at the transition point. We show this explicitely for the two time delayed systems. Further support for our results is provided by computing the spectrum of Lyapunov Exponents (LE) of the hyperchaotic attractor in all cases. Our numerical results imply that the structure of a hyperchaotic attractor is topologically different from that of a chaotic attractor with inherent dual scales, at least for the two general classes of hyperchaotic systems we have analysed here. 相似文献
10.
Recently an analytic algorithm for evaluating the Feigenbaum indices of one-dimensional maps was developed using a perturbative
expansion. We find that the use of Padé approximants in the resulting asymptotic series, significantly improves the technique. 相似文献