排序方式: 共有64条查询结果,搜索用时 15 毫秒
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Alisa D. Kharlamova Anton S. Abel Alexei D. Averin Olga A. Maloshitskaya Vitaly A. Roznyatovskiy Evgenii N. Savelyev Boris S. Orlinson Ivan A. Novakov Irina P. Beletskaya 《Molecules (Basel, Switzerland)》2021,26(7)
N-heteroaryl substituted adamantane-containing amines are of substantial interest for their perspective antiviral and psychotherapeutic activities. Chlorine atom at alpha-position of N-heterocycles has been substituted by the amino group using convenient nucleophilic substitution reactions with a series of adamantylalkylamines. The prototropic equilibrium in these compounds was studied using NMR spectroscopy. The introduction of the second amino substituent in 4-amino-6-chloropyrimidine, 2-amino-chloropyrazine, and 1-amino-3-chloroisoquinoline was achieved using Pd(0) catalysis. 相似文献
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Jester SS Idelson A Schmitz D Eberhagen F Höger S 《Langmuir : the ACS journal of surfaces and colloids》2011,27(13):8205-8215
Shape-persistent rigid phenylene-ethynylene-butadiynylenes form lamellar self-assembled monolayers (SAMs) at the HOPG/TCB interface, which were studied by scanning tunneling microscopy (STM) with submolecular resolution. Substitution of the terminating acetylene functions with polar cyanopropyldimethylsilyl groups leads to 2D phase separation and defined rod-rod interactions, which determine the packing distances between the rigid rods. The results stimulated the connection of rigid rods via septiarylene clamp units. They covalently link two rigid rod units and define the intramolecular rod-rod distance that matches the alkoxy substituent chain lengths. The systems can be described as half-ring structures of two rigid rods connected via a rotatable joint unit. These acetylene-terminated half-ring structures were also oligomerized under Cu and Pd catalysis to yield defined acyclic and cyclic oligomers. Detailed STM studies decoded the molecular origin of the surface patterning of such systems. The dodecyloxy side chains are adsorbed along the HOPG main axes and, together with the alkoxy backbone angle, determine the adsorption direction of the adlayers. 相似文献
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We study a general class of log-gas ensembles on (shifted) quadratic lattices. We prove that the corresponding empirical measures satisfy a law of large numbers and that their global fluctuations are Gaussian with a universal covariance. We apply our general results to analyze the asymptotic behavior of a q-boxed plane partition model introduced by Borodin, Gorin and Rains. In particular, we show that the global fluctuations of the height function on a fixed slice are described by a one-dimensional section of a pullback of the two-dimensional Gaussian free field.Our approach is based on a q-analogue of the Schwinger–Dyson (or loop) equations, which originate in the work of Nekrasov and his collaborators, and extends the methods developed by Borodin, Gorin and Guionnet to quadratic lattices. 相似文献
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The effect of thermal aging on three different elastomeric polyurethane adhesives was studied. Consequently, an attempt was made to predict the polyurethanes' service lifetimes from the changes in tensile properties, hardness of bulk specimens and adhesion strength properties (lap shear and butt joints) of polycarbonate bonded joints. Aging temperatures ranged from ambient to 70 °C (at 50% relative humidity) for durations from 20 days to 18 months. Experimental results were analyzed according to a kinetic rate theory and using limit values for the various properties. Consequently, service lifetimes were determined and compared to results from actual service life. Predictions of long-term performance from accelerated tests proved to be reasonable for the properties and materials studied. 相似文献
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Alisa L. Becker Katja Henzler Nicole Welsch Matthias Ballauff Oleg Borisov 《Current Opinion in Colloid & Interface Science》2012,17(2):90-96
We review the interaction of charged polymeric systems with proteins. In solutions of low ionic strength there are many examples of proteins attracted to polyelectrolytes even if both systems carry the same overall charge. This attractive interaction is widespread, having been observed for single polyelectrolyte chains as well as for polyelectrolytes grafted to surfaces (polyelectrolyte brushes) and charged polymeric networks. In all cases, adding salt weakens the interaction considerably. We discuss the suggestion that the attractive force at low salinity originates from the asymmetry of interaction between charged polymer segments and charged patches on the surface of the protein globule. This can be explained if the attractive force is mainly due to a counterion release force, i.e., the polyelectrolyte chains become the multivalent counterions for the patches of opposite charge localized on the surface of the proteins. We review a selection of simple models that lead to semi-quantitative estimates of this force as the function of salt concentration. 相似文献
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Hnilova M Khatayevich D Carlson A Oren EE Gresswell C Zheng S Ohuchi F Sarikaya M Tamerler C 《Journal of colloid and interface science》2012,365(1):97-102
This study constitutes a demonstration of the biological route to controlled nano-fabrication via modular multi-functional inorganic-binding peptides. Specifically, we use gold- and silica-binding peptide sequences, fused into a single molecule via a structural peptide spacer, to assemble pre-synthesized gold nanoparticles on silica surface, as well as to synthesize nanometallic particles in situ on the peptide-patterned regions. The resulting film-like gold nanoparticle arrays with controlled spatial organization are characterized by various microscopy and spectroscopy techniques. The described bio-enabled, single-step synthetic process offers many advantages over conventional approaches for surface modifications, self-assembly and device fabrication due to the peptides' modularity, inherent biocompatibility, material specificity and catalytic activity in aqueous environments. Our results showcase the potential of artificially-derived peptides to play a key role in simplifying the assembly and synthesis of multi-material nano-systems in environmentally benign processes. 相似文献
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Stuart Clough John Gupton Adepeju Ligali Matthew Roberts David Driscoll Scott Annett Alisa Hewitt Matthew Hudson Edward Jackson Robert Miller Bradley Norwood Rene Kanters Hadley Wyre Heather Petruzzi 《Tetrahedron》2005,61(31):7554-7561
The highly stereoselective conversions of (Z)-3-aryl-3-chloropropenals to (E)-3-alkoxy-3-arylpropenals, to (E)-3-aryl-3-morphorlinopropenals, and to vinamidinium salts are reported. The stereochemical assignments were based on 2D-NMR experiments. 相似文献
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Chemistry of Heterocyclic Compounds - This microreview considers methods for the synthesis of pyrrolo[2,1-a]isoquinolines, published from year 2014 until 2018. 相似文献