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Hadisi Maliheh Vosoughi Naser Yousefnia Hassan Bahrami-Samani Ali Zolghadri Samaneh Vosoughi Sara Alirezapour Behrouz 《Journal of Radioanalytical and Nuclear Chemistry》2022,331(2):841-849
Journal of Radioanalytical and Nuclear Chemistry - In this study, optimized preparation, quality control, cell assessments and biostribution of 188Re-HYNIC-PSMA in normal rats and tumor bearing... 相似文献
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Milani Saeideh Ghaemimanesh Fatemeh Salimi Ali Hadavi Reza Bayat Ali Ahmad Alirezapour Behrouz Rabbani Hodjattallah 《Journal of Radioanalytical and Nuclear Chemistry》2018,316(1):267-273
Journal of Radioanalytical and Nuclear Chemistry - Receptor tyrosine kinase Ror1 is widely expressed during embryogenesis but it is absent within most mature tissues. However, expression of Ror1... 相似文献
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Z. Szűcs S. Takács B. Alirezapour 《Journal of Radioanalytical and Nuclear Chemistry》2014,302(2):1035-1038
A natNi foil was used for the production of 64Cu via 64Ni(p,n)64Cu nuclear reaction when the necessary investment for target material (350 mg) is 50 times less using the natNi instead of 64Ni. The produced 32.2 ± 1.8 MBq of “no carrier added” 64Cu is sufficient for 10 mice trials on small animal PET. The radionuclide contamination was <13 ± 12 kBq for 55Co and 4 ± 2 kBq for 57Ni comparing to minimum detectable activity and only 52 ± 2 kBq of 61Cu was in 64Cu due to the modified ion exchange separation. The concentration of Fe(III) was maintained under 1.7 ppm by precipitation and filtering of Fe(OH)3 due to the chemical purity was required. 相似文献
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Rostampour Malihe Aboudzadeh Mohammadreza Sadeghi Mahdi Hamidi Saeid Alirezapour Behroz Soltani Naser Aslani Gholamreza 《Journal of Radioanalytical and Nuclear Chemistry》2017,314(3):1759-1766
Excitation functions and theoretical yields via charge particle induced reactions were evaluated using EMPIRE-3.2.2 and ALICE/ASH codes and the obtained results have been discussed and compared with the available reported experimental data. It has been verified that natCu(p,n)65Zn reaction is the optimum 65Zn production route. The 65Zn was produced using natCu(p,xn) 65Zn reaction in the energy range of 16.8 → 12.2 MeV with the thick target yield of 0.15 ± 0.005 MBq/μA h. The 65Zn radionuclide was purified by anion exchange chromatography.
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Behrooz Alirezapour Amir Reza Jalilian Mohammad Javad Rasaee Saeed Rajabifar Kamal Yavari Mohsen Kamalidehghan Fatemeh Bolourinovin Gholamreza Aslani 《Journal of Radioanalytical and Nuclear Chemistry》2013,295(2):1261-1271
Breast cancer radioimmunoscintigraphy targeting HER2/neu expression is a growing field of work in nuclear medicine research. Trastuzumab is a monoclonal antibody that binds with high affinity to HER2/neu, which is over expressed on breast and other tumors. Developing new tracers for the detection of this cancer is of great interest. In this study, trastuzumab was successively labeled with [64Cu]CuCl2 after conjugation with DOTA-NHS-ester. The conjugate was purified by molecular filtration, the average number of DOTA conjugated per mAb was calculated and total concentration was determined by spectrophotometric method. DOTA–trastuzumab was labeled with 64Cu produced by 68Zn(p,αn)64Cu nuclear reaction (30 MeV protons at 180 μA). Radiochemical purity, integrity of protein after radiolabeling and immunoreactivity of radiolabeled mAb trastuzumab with HER2/neu antigen and SkBr3 cell line were performed by RIA. In vitro stability of radiolabeled mAb in human serum was determined by thin layer chromatography. In vitro internalization studies were performed with the SkBr3 cell line and the tissue biodistribution of the 64Cu–DOTA–trastuzumab was evaluated in wild-type rat (90 ± 5.5 μCi, 2, 6, 12, 24 h p.i.). The radioimmunoconjugate was prepared with a radiochemical purity of higher than 96 ± 0.5 % (ITLC) and specific activity as high as 5.3 μCi/μg. The average number of chelators per antibody for the conjugate used in this study was 5.8/1. The sample was showed to have similar patterns of migration in the gel electrophoresis. The 64Cu–DOTA–trastuzumab showed high immunoreactivity towards HER2/neu antigen and SkBr3 cell line. In vitro stability of the labeled product was found to be more than 94 % in PBS and 82 ± 0.5 % in human serum over 48 h. In vitro internalization studies of the 64Cu–DOTA–trastuzumab showed that up to 11.5 % of the radioimmunoconjugate internalized after 10 h. The accumulation of the radiolabeled mAb in liver, skin, intestine, lung, spleen, kidney and other tissues demonstrates a similar pattern to the other radiolabeled anti-HER2 immunoconjugates. 64Cu–DOTA–trastuzumab is a potential compound for molecular imaging of PET for diagnosis and treatment studies and follow-up of HER2 expression in oncology. 相似文献
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