The Radon-Nikodým property and weighted trees in Banach spaces

It is known that adual Banach space has the Radon-Nikodym Property if and only if it does not have a tree. It is shown that a Banach space has the Radon-Nikodym Property if and only if it does not have a “weighted tree”. This is part of a Ph.D. thesis written under the supervision of R.C. James.     

Internal Nucleophilic Catalyst Mediated Cyclisation/Ring Expansion Cascades for the Synthesis of Medium‐Sized Lactones and Lactams

A strategy for the synthesis of medium‐sized lactones and lactams from linear precursors is described in which an amine acts as an internal nucleophilic catalyst to facilitate a novel cyclisation/ring expansion cascade sequence. This method obviates the need for the high‐dilution conditions usually associated with medium‐ring cyclisation protocols, as the reactions operate exclusively via kinetically favourable “normal”‐sized cyclic transition states. This same feature also enables biaryl‐containing medium‐sized rings to be prepared with complete atroposelectivity by point‐to‐axial chirality transfer.     

Synthesis and biochemical characterisation of fluorinated analogues of pepstatin A and grassystatin A

Pepstatin A and grassystatin A are natural, statine-containing peptides that act as inhibitors of aspartic protease enzymes. In this work, stereoselective fluorination is investigated as a strategy for enhancing the pharmacodynamic and pharmacokinetic properties of these lead compounds. Fluorination is found to modestly affect the protease inhibitory potency, leading to the identification of two highly active new inhibitors of the cancer-associated protease, cathepsin D. However, no dramatic changes are observed in terms of target selectivity, lipophilicity, membrane permeability or metabolic stability.     

陶瓷微通道内的传热和压降特性

本文对一种新型陶瓷微通道换热器的传热与流动阻力特性进行了实验研究。实验工质分别为3M公司的HFE-7100和水。对于HFE7100流体,在传热面温度为40℃时热流密度可达10W/cm~2;对于水,传热面温度为35℃时热流密度可达约13W/cm~2。流动阻力特性实验结果表明,无论对于水还是HFE7100流体,在本实验范围内压降小于4.8kPa。