Influence of the degree of branching of the O-alkyl radical on the anticholinesterase properties of O-alkyl S-n-butyl methylphosphonothioates

Russian Chemical Bulletin -     

Detection and synthesis of a synergist of the sex pheromone of the cotton bollworm

The synergisic properties of docosa-5Z, 17Z-diene — one of the by-products of the synthesis of the synthetic cotton bollworm pheromone — have been revealed.A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax 627071. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 130–132, January–February, 1994.     

Quantitative determination of the main component of the pheromone of the beet army worm moth as a function of the time of day influence of a brain extract on the induction of the pheromone

A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax 627071. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 137–139, January–February, 1994.     

Synthesis of a number of derivatives of alkaloids and of nitrogen-containing heterocycles and their anticholinesterase activities

N-Methyl- and N-phenylcarbamates based on a number of alkaloids and nitrogen-containing heterocycles have been synthesized, and they have proved to be weak irreversible inhibitors of acetylcholinesterase and butyrylcholinesterase. It has been shown that the choline fragments of the above-mentioned carbamates and their -methylcholine analogs are reversible inhibitors of both cholinesterases and make a substantial contribution to the anticholinesterase activity. Selective inhibitors of ACE and BuCE have been found among the compounds synthesized.A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodynkh Soedinenii, No. 6, pp. 825–831, November–December, 1988.     

Alkaloids ofAnabasis aphylla and their cholinergic activities

A comparative study has been made of the anticholinesterase activities of the methiodides and hydrochlorides of anabasine, lupinine, anabasamine, and methyl aphyllinate, which have proved to be reversible inhibitors of two types of cholinesterases.The materials of this paper were presented at the IInd International Symposium on the Chemistry of Natural Compounds, Eskiehir, Turkey, 1996.A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (371) 162 70 71. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 327–330, May–June, 1998.     

X-ray structural investigation of gossypol and its derivatives XXII. Structure of the H-clathrate of gossypol with dimethyl sulfoxide

In crystals obtained from solutions in DMSO, gossypol molecules are again present in the aldehyde tautomeric form. These crystals are H-clathrates with the channel type of structure which has much in common with the structure of the complexes of gossypol with methanol and with formic acid.Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, Nos. 3,4, pp. 330–334, May–August, 1992.     

Synthesis of the p-toluenesulfonate of oleyl acohol under conditions of phase-transfer catalysis

The tosylation of oleyl alcohol under the conditions of phase-transfer catalysis has been studied. In this process oleyl p-toluenesulfonate of formed with a yield of up to 80%.Institute of Bioorganic Chemistry, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 3, 443–445, May–June, 1988.     

Synthesis of the sex pheromone of the grain moth Ephestia elutella

A most convenient synthesis of tetradeca-9Z,12E-dien-l-ol and its acetate — components of the sex pheromone of the grain moth — has been carried out on the basis of a scheme for obtaining a cis-1,trans-4-dienic system.A. S. Sadykov Institute of Bioorganic Chemistry, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, Vol. 6, pp. 834–840, November–December, 1989.