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1.
Elasasy M. E. A. Elnaggar D. H. Hafez N. A. Abdel Azab M. E. Amr A. E. Omran M. M. Mohamed A. M. 《Russian Journal of General Chemistry》2021,91(5):915-925
Russian Journal of General Chemistry - Some new fluoro-heterocyclic compounds containing thiazole and pyridine moities have been synthesized and studied for their antiproliferative activity.... 相似文献
2.
G. Wu R. M. Izatt M. L. Bruening W. Jiang H. Azab K. E. Krakowiak J. S. Bradshaw 《Journal of inclusion phenomena and macrocyclic chemistry》1992,13(2):121-127
The aqueous protonation and anion-binding SeO
2
–/4
SO
2–
4
, and NO
–
3
) constants of the macrocyclic polyamine ligand, dipyridino-hexaaza-28-crown-8(L), were measured in 0.1M KCl using a potentiometric titration technique. The protonation sequence of the aza groups of L was studied in D2O from the chemical shifts of the nonlabile protons so as to find the charge distribution geometry as a function of pD. The study indicates that in 0.1M KC1 fully protonated L forms stable l: 1 complexes with SeO
2–
4
(logK=3.68) and SO
2–
4
(logK=3.55), but not with NO
–
3
(logK < l.5). All of the amine pK values were above 6.3, thus allowing the use of the protonated form of this ligand over a wide pH range. 相似文献
3.
The secondary dissociation constants of o-phthalic and phosphoric acids have been determined in methanol + water (50 mass %) from reversible e.m.f. measurements of the cell of the type: Pt, H(2)(1 atm)|M(2)A(m), MHA(m), MCl|AgCl; Ag at different temperatures (288.15-308.15 K) and at different ionic strengths. To minimize the unsteadiness in potential measurements palladium coated platinum electrodes have been used. The large set of such e.m.f. values has been analyzed in terms of a multi-linear regression method recommended in recent IUPAC documents. The thermodynamic values DeltaG degrees , DeltaH degrees and DeltaS degrees , for the respective equilibria, were estimated. Standard pH values [pH*(s)] have been assigned to buffers in methanol + water (50 mass %) at temperatures between 288.15 and 308.15 K. 相似文献
4.
H. A. Azab A. M. El-Nady S. A. El-Shatoury 《Monatshefte für Chemie / Chemical Monthly》1994,125(10):1049-1057
Summary The acidity constants of adenosine-5-mono- and diphosphate (AMP andADP) were determined at 25.00±0.1°C by potentiometric titration in pure water and different solvent mixtures (methanol, ethanol, N,N-dimethylformamide, dimethylsulfoxide, acetone, and dioxane). The ionization ofAMP andADP depends on both the proportion and the nature of the organic solvent used. ThepK
a1 values for bothAMP andADP are slightly influenced as the solvent is enriched in ethanol and methanol and remains practically constant in presence of different amounts ofDMF andDMSO. A pronounced change in thepK
a1 values is observed as the solvent is enriched in acetone or dioxane. It is concluded that the electrostatic effect has only a relatively small influence on the dissociation equilibrium, whereas other solvent effects such as solvent basicity, hydrogen bonding and protonsolvent interactions play an important role.
Aciditätskonstanten von Adenosin-5-mono- und -diphosphat in verschiedenen organisch-wäßrigen Lösungsmittelgemischen
Zusammenfassung Die Aciditätskonstanten von Adenosin-5-mono- und -diphosphat wurden bei 25.0±0.1°C in reinem Wasser und in verschiedenen Lösungsmittelgemischen (Methanol, Ethanol, N,N-Dimethylformamid, Dimethylsulfoxid, Aceton und Dioxan) potentiometrisch bestimmt. Der Ionisierungsgrad vonAMP undADP hängt sowohl von der Menge als auch von der Art des organischen Lösungsmittels ab. DiepK a1-Werte vonAMP undADP werden durch Zugabe von Methanol und Ethanol nur wenig, durch verschiedene Mengen vonDMF undDMSO gar nicht, durch Aceton und Dioxan jedoch deutlich beeinflußt. Offensichtlich haben elektrostatische Effekte nur geringe Auswirkungen auf das Dissoziationsgleichgewicht, wogegen andere Faktoren wie Basizität des Lösungsmittels, Wasserstoffbrückenbindungen und Lösungsmittel-Proton-Wechselwirkungen eine bedeutende Rolle spielen.相似文献
5.
H. A. Azab A. M. El-Nady A. Hassan R. S. A. Azkal 《Monatshefte für Chemie / Chemical Monthly》1994,125(10):1059-1066
Summary Potentiometric equilibrium measurements have been made for the interaction of adenosine-5-mono-,-di-, and -triphosphate, and Co(II) with biologically important secondary ligands (malic, maleic, succinic, tartaric, citric, and oxalic acid). The formation of various 1:1:1 mixed ligand complexes inferred from the potentiometric titration curves. Initial estimates of the formation constants of the resulting species and the acid dissociation constants ofAMP,ADP,ATP and the secondary ligand acids have been refined with a computer program. In some systems, the ternary complexes are found to be more stable than the corresponding binary ones. In some ternary systems studied, interligand interactions or some cooperativity between the coordinate ligands, possibly H bond formation, have been found to be most effective in deciding the stability of the complexes formed in solution. Stabilities of mixed ligand complexes increase in the orderAMP <ADP <ATP. With respect to the secondary ligands, the formation constants of the mixed ligand complexes decrease in the following order: succinic > maleic > tartaric > malic > citric > oxalic acid.
Potentiometrische Untersuchung der Bildungsgleichgewichte von binären und ternären Komplexen von Kobalt(II) mit Adenosin-5-mono-, -di- und -triphosphat und einigen biologisch bedeutenden polybasischen Sauerstoffsäuren
Zusammenfassung Die Wechselwirkung vonAMP,ADP undATP mit Co(II) und einigen biologisch interessanten Sekundärliganden (Bernsteinsäure, Hydroxybernsteinsäure, Maleinsäure, Weinsäure, Zitronensäure und Oxalsäure) wurde bei 25°C und einer lonenstärke von 0.1M KNO3 potentiometrisch untersucht. Die Titrationskurven zeigen das Vorliegen von Species der Zusammensetzung 1:1:1 an. Die geschätzten Bildungskonstanten der Komplexe und die Dissoziationskonstanten der Liganden wurden mittels eines Computerprogramms optimiert. In einigen der untersuchten Systeme sind die ternären Komplexe stabiler als die sekundären. Die Stabilität der Verbindungen hängt im wesentlichen von Interligandwechselwirkungen — möglicherweise der Ausbildung von Wasserstoffbrückenbindungen — ab. Die Stabilität der Komplexe mit gemischten Liganden steigt in der ReihenfolgeAMP <ADP <ATP und fällt entsprechend der Serie Bernsteinsäure > Maleinsäure > Weinsäure > Hydroxybernsteinsäure > Zitronensäure > Oxalsäure.相似文献
6.
H. A. Azab A. M. El-Nady A. Hassan R. S. A. Azkal 《Monatshefte für Chemie / Chemical Monthly》1993,124(6-7):637-646
Summary Potentiometric equilibrium measurements have been made at 25±0.1°C (=0.1 mol dm–3 KNO3) for the interaction of adenosine-5-mono-, -di- and -triphosphate (AMP,ADP andATP) and Cu(II) with biologically important secondary ligand acids (malic, maleic, succinic, tartaric, citric and oxalic acids) in a 1:1:1 ratio and the formation of various 1:1:1 mixed ligand complex species inferred from the potentiometricpH titration curves. Initial estimates of the formation constants of the resulting species and the acid dissociation constants ofAMP,ADP,ATP, and secondary ligand acid, have been refined with the SUPERQUAD computer program. In some systems logK values are positive, i.e. the ternary complexes are found to be more stable than the corresponding binary complexes. In some Cu(II) ternary systems the interligand interactions between the coordinate ligands, possibly H bond formation, have been found to be most effective in deciding the stability of the ternary complexes formed in solution. Stabilities of mixed ligand complexes increase in the orderAMP <ADP <ATP. With respect to the secondary ligands, the formation constants of the mixed ligand complexes decrease in the order succinic > maleic > tartaric > malic > citric > oxalic acid.
Ternäre Komplexe in Lösung. Vergleich der Koordinationstendenz einiger polybasischer Sauerstoffsäuren gegenüber binären Komplexen von Cu(II) mitAMP,ADP oderATP
Zusammenfassung Es wurden potentiometrische Gleichgewichtsmessungen bei 25±0.1°C bei =0.1 mol dm–1 KNO3 durchgeführt, um die Wechselwirkung von Adenosin-5-mono-, -di- und triphosphat mit Cu(II) und biologisch relevanten Sekundärliganden wie Äpfel-, Malein-, Bernstein-, Wein-, Zitronen- und Oxalsäure im Verhältnis 1:1:1 festzustellen. Aus den potentiometrischenpH-Titrationskurven ergaben sich verschiedene 1:1:1 gemischte Ligandenkomplexe. Anfänglich abgeschätzte Komplexbildungskonstanten der Komplexe und Säuredissoziationskonstanten vonAMP,ADP undATP und den Sauerstoffsäuren wurden mittels des Computerprogramms SUPERQUAD verfeinert. In einigen Systemen ist logK positiv, demzufolge sind die ternären Komplexe stabiler als die korrespondierenden binären. In einigen ternären Cu(II)-Komplexen bestehen zwischen den Liganden Wechselwirkungen, vermutlich auf der Basis von stabilitätsfördernden Wasserstoffbrückenbindungen. Die Stabilitäten der gemischten Komplexe steigen in der ReihenfolgeAMP <ADP <ATP. Bezüglich der Sekundärliganden ergibt sich für die Bildungskonstanten der ternären Komplexe die Reihung Bersteinsäure > Maleinsäure > Weinsäure > Äpfelsäure > Zitronensäure > Oxalsaure.相似文献
7.
Millions of people around the world suffer from psychiatric illnesses, causing unbearable burden and immense distress to patients and their families. Accumulating evidence suggests that inflammation may contribute to the pathophysiology of psychiatric disorders such as major depression and bipolar disorder. Copious studies have consistently shown that patients with mood disorders have increased levels of plasma tumor necrosis factor (TNF)-α. Given these findings, selective anti-TNF-α compounds were tested as a potential therapeutic strategy for mood disorders. This mini-review summarizes the results of studies that examined the mood-modulating effects of anti-TNF-α drugs. 相似文献
8.
Abdullatif Azab Dorit Moradov Abed Al-Aziz Al-Quntar Morris Srebnik 《Phosphorus, sulfur, and silicon and the related elements》2013,188(8):937-943
Abstract Direct addition of organolithium to 1-alkynylphosphonates (1) afforded vinylphosphonates and enamine phosphonates (2) in good to excellent yields. The reaction was carried out in dry THF at low temperature and proved to be completely stereoselective (syn addition). Alkyl, aryl, and haloalkyl groups were attached to the alkynyl entity, so the resulting vinylphosphonates contained various functional groups. The stereochemistry of the products as well as mechanism of the reaction were determined based on 1H and 13C NMR. The synthesis of enamine phosphonates in the absence of complicated, highly expensive organometallic catalysis has not been previously reported. 相似文献
9.
10.
Hemant Kumar Srivastava Abed Al Aziz Quntar Abdulatif Azab Avital Shurki 《Tetrahedron》2009,65(22):4389-3774
The reaction of 6-chloro-1-hexynylphosphonate with primary and secondary amines afforded exclusively 2-aminocyclohexenylphosphonates in 62-85% isolated yields. In contrast, reaction of various amines with isobutyl 7-chlorohept-2-ynoate in acetonitrile at 70 °C gave (E)-sec-butyl 2-(1-alkylpiperidin-2-ylidene)acetates in 65-78% isolated yields. Calculations offer an explanation for the difference in the behavior of the two compounds classes. It is shown that C-C cyclization in the alkyne-phosphonate group occurs via an initial formation of a zwitterionic intermediate, which is stabilized by both an inductive effect of the phosphonate group and a newly formed hydrogen bond. The alkyne-carboxylate group, on the other hand, proceeds via enamine formation as a result of the smaller inductive effect of the carboxylate combined with involvement of an allene-like resonance form. This resonance form both delocalizes the negative charge in the zwitterionic intermediate making it to be less available for attack, and affects the geometry thus preventing formation of the stabilizing hydrogen bond. Hence, the zwitterionic intermediate of the alkyne-carboxylates is less stable leading to formation of an enamine, which is followed by N-C cyclization to give the azaheterocycles. 相似文献